Now showing items 1-6 of 6

    • Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes 

      Veiga, Patrick; Gallini, Carey Ann; Beal, C.; Michaud, Monia; Delaney, Mary Louise Rodriguez; DuBois, A.; Khlebnikov, A.; van Hylckama Vlieg, J. E. T.; Punit, S.; Glickman, Jonathan Neil; Onderdonk, Andrew Bruce; Glimcher, Laurie Hollis; Garrett, Wendy S. (Proceedings of the National Academy of Sciences, 2010)
      Intestinal health requires the coexistence of eukaryotic self with the gut microbiota and dysregulated host-microbial interactions can result in intestinal inflammation. Here, we show that colitis improved in T-bet(-/-)Rag2(-/-) ...
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma 

      Kostic, Aleksandar David; Gevers, D.; Pedamallu, Chandra Sekhar; Michaud, Monia; Duke, F.; Earl, A. M.; Ojesina, Akinyemi Ifedapo; Jung, J.; Bass, Adam Joel; Tabernero, J.; Baselga, J.; Liu, C.; Shivdasani, Ramesh Arjun; Ogino, Shuji; Birren, B. W.; Huttenhower, Curtis; Garrett, Wendy S.; Meyerson, Matthew Langer (Cold Spring Harbor Laboratory Press, 2011)
      The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to ...
    • Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission 

      Rooks, Michelle G; Veiga, Patrick; Wardwell-Scott, Leslie H; Tickle, Timothy; Segata, Nicola; Michaud, Monia; Gallini, Carey Ann; Beal, Chloé; van Hylckama-Vlieg, Johan ET; Ballal, Sonia Arora; Morgan, Xochitl C; Glickman, Jonathan Neil; Gevers, Dirk; Huttenhower, Curtis; Garrett, Wendy S. (Springer Nature, 2014)
      Dysregulated immune responses to gut microbes are central to inflammatory bowel disease (IBD), and gut microbial activity can fuel chronic inflammation. Examining how IBD-directed therapies influence gut microbiomes may ...
    • Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice 

      Sutherland, Andrew P; Van Belle, Tom; Wurster, Andrea L.; Suto, Akira; Michaud, Monia; Zhang, Dorothy; Grusby, Michael J.; von Herrath, Matthias (American Diabetes Association, 2009)
      OBJECTIVE: Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate ...
    • The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis 

      Smith, Patrick M.; Howitt, Michael; Panikov, Nicolai; Michaud, Monia; Gallini, Carey Ann; Bohlooly-Y, Mohammad; Glickman, Jonathan Neil; Garrett, Wendy S. (American Association for the Advancement of Science (AAAS), 2013)
      Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial species and strain-specific molecules that ...
    • Sequence-Based Discovery of Bradyrhizobium enterica in Cord Colitis Syndrome 

      Bhatt, Ami Bharat; Freeman, Sam Spenser Sharpe; Herrera, Alex Francisco; Pedamallu, Chandra Sekhar; Gevers, Dirk; Duke, Fujiko; Jung, Joonil; Michaud, Monia; Walker, Bruce David; Young, Sally U.; Earl, Ashlee M.; Kostic, Aleksander D.; Ojesina, Akinyemi Ifedapo; Hasserjian, Robert Paul; Ballen, Karen Kuhn; Chen, Yi-Bin Albert; Hobbs, Gabriela; Antin, Joseph Harry; Soiffer, Robert Jon; Baden, Lindsey Robert; Garrett, Wendy S.; Hornick, Jason L.; Marty, Francisco Miguel; Meyerson, Matthew Langer (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND—Immunosuppression is associated with a variety of idiopathic clinical syndromes that may have infectious causes. It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord ...