Browsing by Author "Gregory-Ksander, Meredith"

Now showing items 1-4 of 4

    • An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells 

      Dordea, Ana; Bray, Mark-Anthony; Allen, Kaitlin; Logan, David J.; Fei, Fei; Malhotra, Rajeev; Gregory, Meredith; Carpenter, Anne E.; Buys, Emmanuel (Elsevier BV, 2016)
      A fully automated and robust method was developed to quantify b-III-tubulin-stained retinal ganglion cells, combining computational recognition of individual cells by CellProfiler and a machine-learning tool to teach ...

    • Opposing Roles For Membrane Bound and Soluble Fas Ligand in Glaucoma-Associated Retinal Ganglion Cell Death 

      Hackett, Caroline G.; Abernathy, Emma F.; Hohlbaum, Andreas M.; Moody, Krishna-sulayman L.; Hobson, Maura W.; Jones, Alexander; Karray, Saoussen; Giani, Andrea; John, Simon W. M.; Marshak-Rothstein, Ann; Gregory, Meredith S.; Lee, Karen S.; Saff, Rebecca Rose; Kolovou, Paraskevi-Evi; Chen, Dong Feng; Ksander, Bruce R. (Public Library of Science, 2011)
      Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular ...

    • Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma 

      Ko, Yu-Chieh; Hayton, Sarah R.; Jones, Alexander; Tainsh, Laurel T.; Ren, Ruiyi; Giani, Andrea; Clerté, Maeva; Abernathy, Emma; de Waard, Nadine; Turcotte, Raphael; Nathan, Daniel; Loomis, Stephanie J.; Gong, Haiyan; Brouckaert, Peter; Buys, Emmanuel; Alt, Clemens; Tainsh, Robert Edward Tillinghast; Oh, Dong-Jin; Malhotra, Rajeev; Arora, Pankaj; Yu, Binglan; Scherrer-Crosbie, Marielle; Kang, Jae Hee Hee; Lin, Charles P.; Rhee, Douglas J; Wiggs, Janey Lee; Gregory, Meredith S.; Pasquale, Louis; Bloch, Kenneth Daniel; Ksander, Bruce R. (Public Library of Science, 2013)
      Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the \(α_1\) subunit of the nitric ...

    • Spontaneous Bacterial Keratitis in CD36 Knockout Mice 

      Klocke, Julia; Barcia, Rita N.; Heimer, Susan; Cario, Elke; Zieske, James D.; Gilmore, Michael S.; Ksander, Bruce R.; Gregory, Meredith (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose: CD36 is a Class B scavenger receptor that is constitutively expressed in the corneal epithelium and has been implicated in many homeostatic functions, including the homeostasis of the epidermal barrier. The aim ...