Now showing items 1-4 of 4

    • Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis 

      Theodoropoulou, Sofia; Brodowska, Katarzyna; Kayama, Maki; Morizane, Yuki; Miller, Joan Whitten; Gragoudas, Evangelos Stelios; Vavvas, Demetrios (Public Library of Science, 2013)
      5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed ...
    • Effects of metformin on retinoblastoma growth in vitro and in vivo 

      BRODOWSKA, KATARZYNA; THEODOROPOULOU, SOFIA; HÖRSTE, MELISSA MEYER ZU; PASCHALIS, ELEFTHERIOS I.; TAKEUCHI, KIMIO; SCOTT, GORDON; RAMSEY, DAVID J.; KIERNAN, ELIZABETH; HOANG, MIEN; CICHY, JOANNA; MILLER, JOAN W.; GRAGOUDAS, EVANGELOS S.; VAVVAS, DEMETRIOS G. (D.A. Spandidos, 2014)
      Recent studies suggest that the anti-diabetic drug metformin may reduce the risk of cancer and have anti-proliferative effects for some but not all cancers. In this study, we examined the effects of metformin on human ...
    • Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization 

      Salehi-Had, Hani; Roh, Mi In; Giani, Andrea; Hisatomi, Toshio; Nakao, Shintaro; Kim, Ivana Kyung; Gragoudas, Evangelos Stelios; Vavvas, Demetrios; Guccione, Samira; Miller, Joan Whitten (Public Library of Science, 2011)
      Purpose: The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular ...
    • VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization 

      Ishida, Susumu; Usui, Tomohiko; Yamashiro, Kenji; Kaji, Yuichi; Amano, Shiro; Ogura, Yuichiro; Hida, Tetsuo; Oguchi, Yoshihisa; Ambati, Jayakrishna; Miller, Joan Whitten; Gragoudas, Evangelos Stelios; Ng, Yin-Shan; D'Amore, Patricia Ann; Shima, David T.; Adamis, Anthony Peter (Rockefeller University Press, 2003)
      Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared ...