Browsing by Author "Wilker, Elissa"

Now showing items 1-8 of 8

    • Ambient Temperature and Biomarkers of Heart Failure: A Repeated Measures Analysis 

      Wilker, Elissa Hope; Yeh, Gloria Y.; Wellenius, Gregory Alexander; Davis, Roger B.; Phillips, Russell Scott; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2012)
      Background: Extreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms. Objectives: We hypothesized that outdoor ...

    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...

    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...

    • Long-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Study 

      Wilker, Elissa H.; Mittleman, Murray A.; Coull, Brent A.; Gryparis, Alexandros; Bots, Michiel L.; Schwartz, Joel; Sparrow, David (National Institute of Environmental Health Sciences, 2013)
      Background: Evidence suggests that air pollution is associated with atherosclerosis and that traffic-related particles are a particularly important contributor to the association. Objectives: We investigated the association ...

    • Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter 

      Wilker, Elissa Hope; Mittleman, Murray A.; Litonjua, Augusto Ampil; Poon, Audrey; Baccarelli, Andrea; Suh, Helen; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ...

    • Predicting DNA methylation level across human tissues 

      Ma, Baoshan; Wilker, Elissa H.; Willis-Owen, Saffron A. G.; Byun, Hyang-Min; Wong, Kenny C. C.; Motta, Valeria; Baccarelli, Andrea A.; Schwartz, Joel; Cookson, William O. C. M.; Khabbaz, Kamal; Mittleman, Murray A.; Moffatt, Miriam F.; Liang, Liming (Oxford University Press, 2014)
      Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation ...

    • Short-Term Changes in Ambient Temperature and Risk of Ischemic Stroke 

      Mostofsky, Elizabeth; Wilker, Elissa H.; Schwartz, Joel; Zanobetti, Antonella; Gold, Diane R.; Wellenius, Gregory A.; Mittleman, Murray A. (S. Karger AG, 2014)
      Background: Despite consistent evidence of a higher short-term risk of cardiovascular mortality associated with ambient temperature, there have been discrepant findings on the association between temperature and ischemic ...

    • Short‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study 

      Li, Wenyuan; Wilker, Elissa H.; Dorans, Kirsten S.; Rice, Mary B.; Schwartz, Joel; Coull, Brent A.; Koutrakis, Petros; Gold, Diane R.; Keaney, John F.; Lin, Honghuang; Vasan, Ramachandran S.; Benjamin, Emelia J.; Mittleman, Murray A. (John Wiley and Sons Inc., 2016)
      Background: Short‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying ...