Now showing items 1-16 of 16

    • Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle 

      Tzahor, Eldad; Kempf, Hervé; Mootoosamy, Roy C.; Poon, Andy C.; Abzhanov, Arkhat; Tabin, Clifford James; Dietrich, Susanne; Lassar, Andrew B. (Cold Spring Harbor Laboratory Press, 2003)
      Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk ...
    • Are we there yet? Tracking the Development of New Model Systems 

      Abzhanov, Arkhat; Extavour, Cassandra; Groover, Andrew; Hodges, Scott A.; Hoekstra, Hopi; Kramer, Elena; Monteiro, Antonia (Elsevier, 2008)
      It is increasingly clear that additional "model" systems are needed to elucidate the genetic and developmental basis of organismal diversity. Whereas model system development previously required enormous investment, recent ...
    • Birds have paedomorphic dinosaur skulls 

      Bhullar, Bhart-Anjan Singh; Marugán-Lobón, Jesús; Racimo, Fernando; Bever, Gabe S.; Rowe, Timothy B.; Norell, Mark A.; Abzhanov, Arkhat (Nature Publishing Group, 2012)
      The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of ...
    • Closely related bird species demonstrate flexibility between beak morphology and underlying developmental programs 

      Mallarino, Ricardo; Campas, O.; Fritz, Joerg; Burns, K. J.; Weeks, Olivia Grace; Brenner, Michael P.; Abzhanov, Arkhat (Proceedings of the National Academy of Sciences, 2012)
      The astonishing variation in the shape and size of bird beaks reflects a wide range of dietary specializations that played an important role in avian diversification. Among Darwin's finches, ground finches (Geospiza spp.) ...
    • Convergent Evolution of Sexual Dimorphism in Skull Shape Using Distinct Developmental Strategies 

      Sanger, Thomas; Sherratt, Emma; McGlothlin, Joel W.; Brodie, Edmund D.; Losos, Jonathan; Abzhanov, Arkhat (Wiley-Blackwell, 2013)
      Studies integrating evolutionary and developmental analyses of morphological variation are of growing interest to biologists as they promise to shed fresh light on the mechanisms of morphological diversification. Sexually ...
    • Developing A Community-based Genetic Nomenclature for Anole Lizards 

      Kusumi, Kenro; Kulathinal, Rob J.; Abzhanov, Arkhat; Boissinot, Stephane; Crawford, Nicholas; Faircloth, Brant C.; Glenn, Travis C.; Janes, Daniel E.; Losos, Jonathan; Menke, Douglas B.; Poe, Steven; Sanger, Thomas; Schneider, Christopher; Stapley, Jessica; Wade, Juli; Wilson-Rawls, Jeanne (BioMed Central, 2011)
      Background: Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now ...
    • The evolution and development of the archosaurian head and the origin of the bird skull 

      Bhullar, Bhart-Anjan Singh (2014-06-06)
      Abstract: Archosauria, the "ruling reptiles," characterized along their stem by relatively large, macrocarnivorous animals, are today represented by two enormously successful but divergent extant clades: Aves, the birds, ...
    • Insights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence 

      Rands, Chris M; Darling, Aaron; Fujita, Matthew; Kong, Lesheng; Webster, Matthew T; Clabaut, Céline; Emes, Richard D; Heger, Andreas; Meader, Stephen; Hawkins, Michael Brent; Eisen, Michael B; Teiling, Clotilde; Affourtit, Jason; Boese, Benjamin; Grant, Peter R; Grant, Barbara Rosemary; Eisen, Jonathan A; Abzhanov, Arkhat; Ponting, Chris P (BioMed Central, 2013)
      Background: A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin’s (Galápagos) finches (Thraupidae, Passeriformes). Their adaptive ...
    • Novel regulation of the homeotic gene Scr associated with a crustacean leg-to-maxilliped appendage transformation. 

      Abzhanov, Arkhat; Kaufman, Thomas C. (The Company of Biologists, 1999)
      Homeotic genes are known to be involved in patterning morphological structures along the antero-posterior axis of insects and vertebrates. Because of their important roles in development, changes in the function and ...
    • Paths Less Traveled: Evo-Devo Approaches to Investigating Animal Morphological Evolution 

      Mallarino, Ricardo; Abzhanov, Arkhat (Annual Reviews, 2012)
      One of the chief aims of modern biology is to understand the causes and mechanisms of morphological evolution. Multicellular animals display a stunning diversity of shapes and sizes of their bodies and individual suborganismal ...
    • Peripheral Arterial Occlusive Disease: Global Gene Expression Analyses Suggest a Major Role for Immune and Inflammatory Responses 

      Crawford, Keith; Jin, Jason Gang; Du, Yanzhi; Abzhanov, Arkhat; Zhou, Jianqin; Zhang, Ji; Jiang, Mier; Ohno-Machado, Lucila; Fu, Shijun; Zhao, Haiguang; Shi, Jiantao; Kuo, Winston (BioMed Central, 2008)
      Background Peripheral arterial disease (PAD), a major manifestation of atherosclerosis, is associated with significant cardiovascular morbidity, limb loss and death. However, mechanisms underlying the genesis and progression ...
    • Regulation of skeletogenic differentiation in cranial dermal bone 

      Abzhanov, Arkhat; Rodda, S. J.; McMahon, A. P.; Tabin, Clifford James (The Company of Biologists, 2007)
      Although endochondral ossification of the limb and axial skeleton is relatively well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skeletal elements is not nearly as well-characterized. ...
    • Role of the Extreme Anterior Domain Organizer in Craniofacial Development 

      Jacox, Laura Anne (2015-05-19)
      Craniofacial development is an intricate process, involving cranial neural crest (NC) and anterior facial tissue. NC migration is regulated by multiple mechanisms and activity of one or more organizer regions. Work presented ...
    • Scaling and shear transformations capture beak shape variation in Darwin's finches 

      Campas, O.; Mallarino, Ricardo; Herrel, A; Abzhanov, Arkhat; Brenner, M (Proceedings of the National Academy of Sciences, 2010)
      Evolution by natural selection has resulted in a remarkable diversity of organism morphologies that has long fascinated scientists and served to establish the first relations among species. Despite the essential role of ...
    • Sequencing Three Crocodilian Genomes to Illuminate the Evolution of Archosaurs and Amniotes 

      St John, John A; Braun, Edward L; Isberg, Sally R; Miles, Lee G; Chong, Amanda Y; Gongora, Jaime; Dalzell, Pauline; Bed'Hom, Bertrand; Burgess, Shane C; Cooksey, Amanda M; Castoe, Todd A; Densmore, Llewellyn D; Drew, Jennifer C; Faircloth, Brant C; Greenwold, Matthew J; Hoffmann, Federico G; Howard, Jonathan M; Iguchi, Taisen; Janes, Daniel E; Khan, Shahid Yar; Kohno, Satomi; de Koning, AP Jason; Lance, Stacey L; McCarthy, Fiona M; McCormack, John E; Merchant, Mark E; Peterson, Daniel G; Pollock, David D; Pourmand, Nader; Raney, Brian J; Roessler, Kyria A; Sanford, Jeremy R; Sawyer, Roger H; Schmidt, Carl J; Triplett, Eric W; Tuberville, Tracey D; Venegas-Anaya, Miryam; Howard, Jason T; Jarvis, Erich D; Guillette, Louis J; Glenn, Travis C; Ray, David A; Moran, Christopher J; Abzhanov, Arkhat; Crawford, Nicholas G.; Moran, Christopher; Edwards, Scott V.; Fujita, Matthew; Green, Richard E. (BioMed Central, 2012)
      The International Crocodilian Genomes Working Group (ICGWG) will sequence and assemble the American alligator (Alligator mississippiensis), saltwater crocodile (Crocodylus porosus) and Indian gharial (Gavialis gangeticus) ...
    • Two developmental modules establish 3D beak-shape variation in Darwin's finches 

      Mallarino, Ricardo; Grant, P. R.; Grant, B. R.; Herrel, Antony; Kuo, W. P.; Abzhanov, Arkhat (Proceedings of the National Academy of Sciences, 2011)
      Bird beaks display tremendous variation in shape and size, which is closely associated with the exploitation of multiple ecological niches and likely played a key role in the diversification of thousands of avian species. ...