Now showing items 1-20 of 22

    • Career on the Move: Geography, Stratification, and Scientific Impact 

      Deville, Pierre; Wang, Dashun; Sinatra, Roberta; Song, Chaoming; Blondel, Vincent D.; Barabási, Albert-László (Nature Publishing Group, 2014)
      Changing institutions is an integral part of an academic life. Yet little is known about the mobility patterns of scientists at an institutional level and how these career choices affect scientific outcomes. Here, we examine ...
    • Control Capacity and A Random Sampling Method in Exploring Controllability of Complex Networks 

      Jia, Tao; Barabási, Albert-László (Nature Publishing Group, 2013)
      Controlling complex systems is a fundamental challenge of network science. Recent advances indicate that control over the system can be achieved through a minimum driver node set (MDS). The existence of multiple MDS's ...
    • Control Centrality and Hierarchical Structure in Complex Networks 

      Liu, Yang-Yu; Slotine, Jean-Jacques; Barabasi, Albert-Laszio (Public Library of Science, 2012)
      We introduce the concept of control centrality to quantify the ability of a single node to control a directed weighted network. We calculate the distribution of control centrality for several real networks and find that ...
    • A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome 

      Ghiassian, Susan Dina; Menche, Jörg; Barabási, Albert-László (Public Library of Science, 2015)
      The observation that disease associated proteins often interact with each other has fueled the development of network-based approaches to elucidate the molecular mechanisms of human disease. Such approaches build on the ...
    • A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease 

      Menche, Jörg; Sharma, Amitabh; Cho, Michael H; Mayer, Ruth J; Rennard, Stephen I; Celli, Bartolome; Miller, Bruce E; Locantore, Nick; Tal-Singer, Ruth; Ghosh, Soumitra; Larminie, Chris; Bradley, Glyn; Riley, John H; Agusti, Alvar; Silverman, Edwin K; Barabási, Albert-László (BioMed Central, 2014)
      Background: An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us ...
    • Effect of Correlations on Network Controllability 

      Pósfai, Márton; Liu, Yang-Yu; Slotine, Jean-Jacques; Barabasi, Albert-Laszio (Nature Publishing Group, 2013)
      A dynamical system is controllable if by imposing appropriate external signals on a subset of its nodes, it can be driven from any initial state to any desired state in finite time. Here we study the impact of various ...
    • Endophenotype Network Models: Common Core of Complex Diseases 

      Ghiassian, Susan Dina; Menche, Jörg; Chasman, Daniel I.; Giulianini, Franco; Wang, Ruisheng; Ricchiuto, Piero; Aikawa, Masanori; Iwata, Hiroshi; Müller, Christian; Zeller, Tania; Sharma, Amitabh; Wild, Philipp; Lackner, Karl; Singh, Sasha; Ridker, Paul M.; Blankenberg, Stefan; Barabási, Albert-László; Loscalzo, Joseph (Nature Publishing Group, 2016)
      Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view is emerging that emphasizes that different diseases often have ...
    • From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration 

      Gomez-Cabrero, David; Menche, Jörg; Vargas, Claudia; Cano, Isaac; Maier, Dieter; Barabási, Albert-László; Tegnér, Jesper; Roca, Josep (BioMed Central, 2016)
      Background: Deep mining of healthcare data has provided maps of comorbidity relationships between diseases. In parallel, integrative multi-omics investigations have generated high-resolution molecular maps of putative ...
    • A genetic epidemiology approach to cyber-security 

      Gil, Santiago; Kott, Alexander; Barabási, Albert-László (Nature Publishing Group, 2014)
      While much attention has been paid to the vulnerability of computer networks to node and link failure, there is limited systematic understanding of the factors that determine the likelihood that a node (computer) is ...
    • Geographic Constraints on Social Network Groups 

      Onnela, Jukka-Pekka; Arbesman, Samuel; González, Marta C.; Barabasi, Albert-Laszlo; Christakis, Nicholas (Public Library of Science (PLoS), 2011)
      Social groups are fundamental building blocks of human societies. While our social interactions have always been constrained by geography, it has been impossible, due to practical difficulties, to evaluate the nature of ...
    • Network link prediction by global silencing of indirect correlations 

      Barzel, Baruch; Barabási, Albert-László (2013)
      Predicting physical and functional links between cellular components is a fundamental challenge of biology and network science. Yet, correlations, a ubiquitous input for biological link prediction, are affected by both ...
    • Network-based in silico drug efficacy screening 

      Guney, Emre; Menche, Jörg; Vidal, Marc; Barábasi, Albert-László (Nature Publishing Group, 2016)
      The increasing cost of drug development together with a significant drop in the number of new drug approvals raises the need for innovative approaches for target identification and efficacy prediction. Here, we take advantage ...
    • PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation 

      Iwata, Hiroshi; Goettsch, Claudia; Sharma, Amitabh; Ricchiuto, Piero; Goh, Wilson Wen Bin; Halu, Arda; Yamada, Iwao; Yoshida, Hideo; Hara, Takuya; Wei, Mei; Inoue, Noriyuki; Fukuda, Daiju; Mojcher, Alexander; Mattson, Peter C.; Barabási, Albert-László; Boothby, Mark; Aikawa, Elena; Singh, Sasha A.; Aikawa, Masanori (Nature Publishing Group, 2016)
      Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that ...
    • Quantifying Information Flow During Emergencies 

      Gao, Liang; Song, Chaoming; Gao, Ziyou; Barabási, Albert-László; Bagrow, James P.; Wang, Dashun (Nature Publishing Group, 2014)
      Recent advances on human dynamics have focused on the normal patterns of human activities, with the quantitative understanding of human behavior under extreme events remaining a crucial missing chapter. This has a wide ...
    • Returners and explorers dichotomy in human mobility 

      Pappalardo, Luca; Simini, Filippo; Rinzivillo, Salvatore; Pedreschi, Dino; Giannotti, Fosca; Barabási, Albert-László (Nature Pub. Group, 2015)
      The availability of massive digital traces of human whereabouts has offered a series of novel insights on the quantitative patterns characterizing human mobility. In particular, numerous recent studies have lead to an ...
    • Systems Medicine: from molecular features and models to the clinic in COPD 

      Gomez-Cabrero, David; Menche, Jörg; Cano, Isaac; Abugessaisa, Imad; Huertas-Migueláñez, Mercedes; Tenyi, Akos; de Mas, Igor Marin; Kiani, Narsis A; Marabita, Francesco; Falciani, Francesco; Burrowes, Kelly; Maier, Dieter; Wagner, Peter; Selivanov, Vitaly; Cascante, Marta; Roca, Josep; Barabási, Albert-László; Tegnér, Jesper (BioMed Central, 2014)
      Background and hypothesis Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify ...
    • Target control of complex networks 

      Gao, Jianxi; Liu, Yang-Yu; D'Souza, Raissa M.; Barabási, Albert-László (Nature Pub. Group, 2014)
      Controlling large natural and technological networks is an outstanding challenge. It is typically neither feasible nor necessary to control the entire network, prompting us to explore target control: the efficient control ...
    • Tissue Specificity of Human Disease Module 

      Kitsak, Maksim; Sharma, Amitabh; Menche, Jörg; Guney, Emre; Ghiassian, Susan Dina; Loscalzo, Joseph; Barabási, Albert-László (Nature Publishing Group, 2016)
      Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical manifestations of genetic diseases are usually highly tissue-specific. Although some disease genes are expressed only ...
    • Trade-offs between driving nodes and time-to-control in complex networks 

      Pequito, Sérgio; Preciado, Victor M.; Barabási, Albert-László; Pappas, George J. (Nature Publishing Group, 2017)
      Recent advances in control theory provide us with efficient tools to determine the minimum number of driving (or driven) nodes to steer a complex network towards a desired state. Furthermore, we often need to do it within ...
    • Uncovering the role of elementary processes in network evolution 

      Ghoshal, Gourab; Chi, Liping; Barabási, Albert-László (Nature Publishing Group, 2013)
      The growth and evolution of networks has elicited considerable interest from the scientific community and a number of mechanistic models have been proposed to explain their observed degree distributions. Various microscopic ...