Now showing items 1-5 of 5

    • Abnormal Calcium Handling and Exaggerated Cardiac Dysfunction in Mice with Defective Vitamin D Signaling 

      Choudhury, Sangita; Bae, Soochan; Ke, Qingen; Lee, Ji Yoo; Singh, Sylvia S.; St-Arnaud, René; del Monte, Federica; Kang, Peter M. (Public Library of Science, 2014)
      Aim Altered vitamin D signaling is associated with cardiac dysfunction, but the pathogenic mechanism is not clearly understood. We examine the mechanism and the role of vitamin D signaling in the development of cardiac ...
    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...
    • Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy 

      Patten, Ian S.; Farrell, Caitlin; Tudorache, Igor; Bauersachs, Johann; Hilfiker-Kleiner, Denise; Rana, Sarosh; Shahul, Sajid Saleem; Rowe, Glenn C; Jang, Cholsoon; Liu, Laura; Hacker, Michele Renee; Rhee, Julie S; Mitchell, John D.; Mahmood, Feroze-Ud-Den; Hess, Philip E.; Koulisis, Nicole; Khankin, Eliyahu; Burke, Suzanne Diana; Del Monte, Federica; Karumanchi, Subbian Ananth; Arany, Zoltan Pierre (Nature Publishing Group, 2012)
      Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and ...
    • Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity 

      Bernini, Fabrizio; Malferrari, Daniele; Pignataro, Marcello; Bortolotti, Carlo Augusto; Di Rocco, Giulia; Lancellotti, Lidia; Brigatti, Maria Franca; Kayed, Rakez; Borsari, Marco; Del Monte, Federica; Castellini, Elena (Springer Nature, 2016)
      The pathological hallmark of misfolded protein diseases and aging is the accumulation of proteotoxic aggregates. However, the mechanisms of proteotoxicity and the dynamic changes in fiber formation and dissemination remain ...
    • Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases 

      Choukroun, Gabriel; Hajjar, Roger; Fry, Stefanie; Del Monte, Federica; Haq, Syed; Guerrero, J. Luis; Picard, Michael Howard; Rosenzweig, Anthony; Force, Thomas (American Society for Clinical Investigation, 1999)
      Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic ...