Now showing items 1-12 of 12

    • Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging 

      Rathi, Yogesh; Malcolm, James; Michailovich, Oleg; Goldstein, Jill M.; Seidman, Larry Joel; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Springer Science + Business Media, 2010)
      Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ...
    • Clinical high risk and first episode schizophrenia: Auditory event-related potentials 

      Del Re, Elisabetta; Spencer, Kevin M.; Oribe, Naoya; Mesholam-Gately, Raquelle; Goldstein, Jill M.; Shenton, Martha Elizabeth; Petryshen, Tracey Lynn; Seidman, Larry Joel; McCarley, Robert William; Niznikiewicz, Margaret A. (Elsevier BV, 2015)
      The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with ...
    • Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset 

      Pasternak, Ofer; Westin, Carl-Fredrik; Bouix, Sylvain; Seidman, Larry Joel; Goldstein, Jill M.; Woo, Tsung-Ung Wilson; Petryshen, Tracey Lynn; Mesholam-Gately, Raquelle; McCarley, Robert William; Kikinis, Ron; Shenton, Martha Elizabeth; Kubicki, Marek R. (Society for Neuroscience, 2012)
      Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ...
    • Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study 

      Lee, Sang-Hyuk; Kubicki, Marek R.; Asami, Takeshi; Seidman, Larry Joel; Goldstein, Jill M.; Mesholam-Gately, Raquelle; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2013)
      Background—Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), ...
    • Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth 

      Woodberry, Kristen Anne; Serur, Rachael A.; Hallinan, Sean B.; Mesholam-Gately, Raquelle; Giuliano, Anthony J.; Wojcik, Joanne Doller; Keshavan, Matcheri S; Frazier, Jean A.; Goldstein, Jill M.; Shenton, Martha Elizabeth; McCarley, Robert William; Seidman, Larry Joel (Elsevier BV, 2014)
      Background—Psychosis prevention and early intervention efforts in schizophrenia have focused increasingly on sub-threshold psychotic symptoms in adolescents and young adults. Although many youth report symptom onset prior ...
    • Importance of Reward and Prefrontal Circuitry in Hunger and Satiety: Prader-Willi Syndrome vs. Simple Obesity 

      Holsen, Laura M; Savage, Cary R.; Martin, Laura E.; Bruce, Amanda S.; Lepping, Rebecca J.; Ko, Eunice; Brooks, William M.; Butler, Merlin G.; Zarcone, Jennifer R.; Goldstein, Jill M. (2011)
      Background: The majority of research on obesity has focused primarily on clinical features (eating behavior, adiposity measures), or peripheral appetite-regulatory peptides (leptin, ghrelin). However, recent functional ...
    • Molecular Profiles of Parvalbumin-Immunoreactive Neurons in the Superior Temporal Cortex in Schizophrenia 

      Pietersen, Charmaine Y.; Mauney, Sarah A.; Kim, Susie S.; Passeri, Eleonora; Lim, Maribel P.; Rooney, Robert J.; Goldstein, Jill M.; Petreyshen, Tracey L.; Seidman, Larry Joel; Shenton, Martha Elizabeth; McCarley, Robert William; Sonntag, Kai-Christian; Woo, Tsung-Ung Wilson (Informa Healthcare, 2014)
      Dysregulation of pyramidal cell network function by the soma- and axon-targeting inhibitory neurons that contain the calcium-binding protein parvalbumin (PV) represents a core pathophysiological feature of schizophrenia. ...
    • Molecular Profiles of Pyramidal Neurons in the Superior Temporal Cortex in Schizophrenia 

      Pietersen, Charmaine Y.; Mauney, Sarah A.; Kim, Susie S.; Lim, Maribel P.; Rooney, Robert J.; Goldstein, Jill M.; Petryshen, Tracey L.; Seidman, Larry J.; Shenton, Martha E.; McCarley, Robert W.; Sonntag, Kai-C.; Woo, Tsung-Ung W. (Informa Healthcare, 2014)
      Disrupted synchronized oscillatory firing of pyramidal neuronal networks in the cerebral cortex in the gamma frequency band (i.e., 30–100 Hz) mediates many of the cognitive deficits and symptoms of schizophrenia. In fact, ...
    • Prenatal Exposure to Lead, δ-Aminolevulinic Acid, and Schizophrenia: Further Evidence 

      Opler, Mark G.A.; Groeger, Justina; McKeague, Ian; Wei, Catherine; Factor-Litvak, Pam; Bresnahan, Michaeline; Graziano, Joseph; Brown, Alan S.; Susser, Ezra S.; Buka, Stephen L.; Goldstein, Jill M.; Seidman, Larry Joel (National Institute of Environmental Health Sciences, 2008)
      Background: A previously conducted study of prenatal lead exposure and schizophrenia using δ-aminolevulinic acid, a biologic marker of Pb exposure, in archived maternal serum samples collected from subjects enrolled in the ...
    • Sex Differences in the Neurobiology of Fear Conditioning and Extinction: A Preliminary fMRI Study of Shared Sex Differences with Stress-Arousal Circuitry 

      Lebron-Milad, Kelimer; Milad, Mohammed Ragib; Abbs, Brandon R.; Linnman, Clas; Rougemount-Bücking, Ansgar; Zeidan, Mohammed A.; Holt, Daphne J.; Goldstein, Jill M. (BioMed Central, 2012)
      Background: The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning and extinction, and are brain regions known to be sexually dimorphic. We used functional ...
    • Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia 

      Rathi, Yogesh; Kubicki, Marek R.; Bouix, Sylvain; Westin, Carl-Fredrik; Goldstein, Jill M.; Seidman, Larry Joel; Mesholam-Gately, Raquelle; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2011)
      This work proposes a new method to detect abnormalities in fiber bundles of first-episode (FE) schizophrenia patients. Existing methods have either examined a particular region of interest (ROI) or used voxel based morphometry ...
    • White matter tract abnormalities between rostral middle frontal gyrus, inferior frontal gyrus and striatum in first-episode schizophrenia 

      Quan, Meina; Lee, Sang-Hyuk; Kubicki, Marek R.; Kikinis, Zora; Rathi, Yogesh; Seidman, Larry Joel; Mesholam-Gately, Raquelle; Goldstein, Jill M.; McCarley, Robert William; Shenton, Martha Elizabeth; Levitt, James Jonathan (Elsevier BV, 2013)
      Background—Previous studies have shown that frontostriatal networks, especially those involving dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) mediate cognitive functions some of which ...