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    • High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms 

      Kurki, Mitja I.; Gaál, Emília Ilona; Kettunen, Johannes; Lappalainen, Tuuli; Menelaou, Androniki; Anttila, Verneri; van 't Hof, Femke N. G.; von und zu Fraunberg, Mikael; Helisalmi, Seppo; Hiltunen, Mikko; Lehto, Hanna; Laakso, Aki; Kivisaari, Riku; Koivisto, Timo; Ronkainen, Antti; Rinne, Jaakko; Kiemeney, Lambertus A. L.; Vermeulen, Sita H.; Kaunisto, Mari A.; Eriksson, Johan G.; Aromaa, Arpo; Perola, Markus; Lehtimäki, Terho; Raitakari, Olli T.; Salomaa, Veikko; Gunel, Murat; Dermitzakis, Emmanouil T.; Ruigrok, Ynte M.; Rinkel, Gabriel J. E.; Niemelä, Mika; Hernesniemi, Juha; Ripatti, Samuli; de Bakker, Paul I. W.; Palotie, Aarno; Jääskeläinen, Juha E. (Public Library of Science, 2014)
      3% of the population develops saccular intracranial aneurysms (sIAs), a complex trait, with a sporadic and a familial form. Subarachnoid hemorrhage from sIA (sIA-SAH) is a devastating form of stroke. Certain rare genetic ...