Now showing items 1-15 of 15

    • Adam8 Limits the Development of Allergic Airway Inflammation in Mice 

      Knolle, M. D.; Nakajima, T.; Hergrueter, A.; Gupta, K.; Polverino, Francesca; Craig, V; Fyfe, S. E.; Zahid, M.; Permaul, Perdita; Cernadas, Manuela; Montano, Giancarlo Vengco; Tesfaigzi, Y.; Sholl, Lynette Marie; Kobzik, Lester; Israel, Elliot; Owen, Caroline Ann (The American Association of Immunologists, 2013)
      To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in ...
    • Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler 

      Price, David B.; Colice, Gene; Israel, Elliot; Roche, Nicolas; Postma, Dirkje S.; Guilbert, Theresa W.; van Aalderen, Willem M.C.; Grigg, Jonathan; Hillyer, Elizabeth V.; Thomas, Victoria; Martin, Richard J. (European Respiratory Society, 2016)
      Asthma management guidelines recommend adding a long-acting β2-agonist (LABA) or increasing the dose of inhaled corticosteroid (ICS) as step-up therapy for patients with uncontrolled asthma on ICS monotherapy. However, it ...
    • Asthma Is More Severe in Older Adults 

      Zein, Joe G.; Dweik, Raed A.; Comhair, Suzy A.; Bleecker, Eugene R.; Moore, Wendy C.; Peters, Stephen P.; Busse, William W.; Jarjour, Nizar N.; Calhoun, William J.; Castro, Mario; Chung, K. Fan; Fitzpatrick, Anne; Israel, Elliot; Teague, W. Gerald; Wenzel, Sally E.; Love, Thomas E.; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2015)
      Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods: This is a ...
    • Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD 

      Postma, Dirkje S; Roche, Nicolas; Colice, Gene; Israel, Elliot; Martin, Richard J; van Aalderen, Willem MC; Grigg, Jonathan; Burden, Anne; Hillyer, Elizabeth V; von Ziegenweidt, Julie; Gopalan, Gokul; Price, David (Dove Medical Press, 2014)
      Purpose Small airway changes and dysfunction contribute importantly to airway obstruction in chronic obstructive pulmonary disease (COPD), which is currently treated with inhaled corticosteroids (ICS) and long-acting ...
    • Corticosteroid Suppression of Lipoxin A\(_4\) and Leukotriene B\(_4\) from Alveolar Macrophages in Severe Asthma 

      Bhavsar, Pankaj K; Levy, Bruce David; Hew, Mark J; Pfeffer, Michael A; Kazani, Shamsah; Israel, Elliot; Chung, Kian Fan (BioMed Central, 2010)
      Background: An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B\(_4\) (LTB\(_4\)), and lipoxin A\(_4\) (LXA\(_4\)) production ...
    • Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study 

      Martin, Richard J; Price, David; Roche, Nicolas; Israel, Elliot; van Aalderen, Willem MC; Grigg, Jonathan; Postma, Dirkje S; Guilbert, Theresa W; Hillyer, Elizabeth V; Burden, Anne; von Ziegenweidt, Julie; Colice, Gene (Nature Publishing Group, 2014)
      Background: Real-life studies are needed to determine the cost-effectiveness of asthma therapies in clinical practice. Aim: To compare the cost-effectiveness of extrafine-particle inhaled corticosteroid (ICS) with standard ...
    • Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands 

      van der Molen, Thys; Postma, Dirkje S.; Martin, Richard J.; Herings, Ron M. C.; Overbeek, Jetty A.; Thomas, Victoria; Miglio, Cristiana; Dekhuijzen, Richard; Roche, Nicolas; Guilbert, Theresa; Israel, Elliot; van Aalderen, Wim; Hillyer, Elizabeth V.; van Rysewyk, Simon; Price, David B. (BioMed Central, 2016)
      Background: Most randomised clinical trials typically exclude a significant proportion of asthma patients, including those at higher risk of adverse events, with comorbidities, obesity, poor inhaler technique and adherence, ...
    • Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells 

      Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D.; Kwiatkowski, David; Yu, Jane J. (The Rockefeller University Press, 2014)
      Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting ...
    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...
    • IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity 

      Kim, Hye Young; Lee, Hyun Jun; Chang, Ya-Jen; Pichavant, Muriel; Shore, Stephanie A.; Fitzgerald, Katherine A.; Iwakura, Yoichiro; Israel, Elliot; Bolger, Kenneth; Faul, John; DeKruyff, Rosemarie H.; Umetsu, Dale T. (2014)
      Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for ...
    • Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012 

      Zein, Joe G.; Udeh, Belinda L.; Teague, W. Gerald; Koroukian, Siran M.; Schlitz, Nicholas K.; Bleecker, Eugene R.; Busse, William B.; Calhoun, William J.; Castro, Mario; Comhair, Suzy A.; Fitzpatrick, Anne M.; Israel, Elliot; Wenzel, Sally E.; Holguin, Fernando; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2016)
      Background: Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has been given to the independent role of age on ...
    • Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics 

      Arm, Jonathan P; Boyce, Joshua A; Wang, Lin; Chhay, Heng; Zahid, Muhammad; Patil, Vaishali; Govindarajulu, Usha; Ivester, Priscilla; Weaver, Kelly L; Sergeant, Susan; Israel, Elliot; Chilton, Floyd H (BioMed Central, 2013)
      Background: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) ...
    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...
    • LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma 

      Kazani, Shamsah; Arm, Jonathan P; Boyce, Joshua; Chhay, Heng; Dutile, Stefanie; Wechsler, Michael E; Govindarajulu, Usha; Ivester, Priscilla; Ainsworth, Hannah C; Sergeant, Susan; Chilton, Floyd H; Israel, Elliot (Springer International Publishing, 2014)
      Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the ...
    • Unjamming and cell shape in the asthmatic airway epithelium 

      Park, Jin-Ah; Kim, Jae Hun; Bi, Dapeng; Mitchel, Jennifer; Qazvini, Nader Taheri; Tantisira, Kelan; Park, Chan Young Young; McGill, Maureen P; Kim, Sae-Hoon; Gweon, Bomi; Notbohm, Jacob K; Steward Jr, Robert; Burger, Stephanie; Randell, Scott H.; Kho, Alvin Thong-Juak; Tambe, Dhananjay; Hardin, Corey; Shore, Stephanie Ann; Israel, Elliot; Weitz, David A.; Tschumperlin, Daniel; Henske, Elizabeth Petri; Weiss, Scott Tillman; Manning, Mary Ellen; Butler, James P.; Drazen, Jeffrey Mark; Fredberg, Jeffrey J. (Nature Publishing Group, 2015)
      From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems— both inert and living—have the potential to jam. The collective can sometimes flow like a ...