Browsing by Author "Gaudelli, Nicole"

Now showing items 1-1 of 1

    • Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors 

      Huang, Tony; Zhao, Kevin; Miller, Shannon; Gaudelli, Nicole; Oakes, Benjamin; Fellmann, Christof; Savage, David; Liu, David (Springer Science and Business Media LLC, 2019-05-20)
      Base editing requires that the target sequence satisfy the protospacer adjacent motif requirement of the Cas9 domain and that the target nucleotide be located within the editing window of the base editor. To increase the ...