Browsing by Author "Fu, Yang"

Now showing items 1-4 of 4

    • Intermediate filaments enable pathogen docking to trigger type 3 effector translocation 

      Russo, Brian C.; Stamm, Luisa M.; Raaben, Matthijs; Kim, Caleb M.; Kahoud, Emily; Robinson, Lindsey R.; Bose, Sayantan; Queiroz, Ana L.; Herrera, Bobby Brooke; Baxt, Leigh A.; Mor-Vaknin, Nirit; Fu, Yang; Molina, Gabriel; Markovitz, David M.; Whelan, Sean P.; Goldberg, Marcia B. (2016)
      Type 3 secretion systems (T3SSs) of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryotic cytosol. Effectors traverse the plasma membrane through a translocon pore formed by ...

    • Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation 

      Lu, Richard; Herrera, Bobby Brooke; Eshleman, Heather D.; Fu, Yang; Bloom, Alexander; Li, Zhigang; Sacks, David B.; Goldberg, Marcia B. (Public Library of Science, 2015)
      The intracellular bacterial pathogen Shigella infects and spreads through the human intestinal epithelium. Effector proteins delivered by Shigella into cells promote infection by modulating diverse host functions. We ...

    • Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex 

      Lu, Jiayun; Kong, Nikki; Carroll, John; Capogrossi, Maurizio; Jeong, Ha-Won; Yang, Yang; Luo, Hongbo; Silberstein, Leslie E.; Chai, Li; Ma, Yupo (Public Library of Science, 2009)
      Background The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a unique gene that is involved in self-renewal in ESC and leukemic stem cell (LSC).Methodology/Principal ...

    • Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells 

      Ho, Brian; Fu, Yang; Dong, Tao; Mekalanos, John (Proceedings of the National Academy of Sciences, 2017-08-14)
      This work demonstrates that it is possible to alter the prey target range of the antibacterial activity of the type 6 secretion system (T6SS). Being able to change the T6SS target specificity is the first step toward using ...