Now showing items 1-15 of 15

    • Blood Banking in Living Droplets 

      Samot, Josh; Moon, Sangjun; Shao, Lei; Zhang, Xiaohui; Xu, Feng; Song, YoungSeok; Keles, Hasan Onur; Matloff, Laura; Markel, Jordan; Demirci, Utkan (Public Library of Science, 2011)
      Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional ...
    • Drop-on-Demand Single Cell Isolation and Total RNA Analysis 

      Moon, Sangjun; Kim, Yun-Gon; Dong, Lingsheng; Lombardi, Michael; Haeggstrom, Edward Olof; Jensen, Roderick V.; Hsiao, Li-Li; Demirci, Utkan (Public Library of Science, 2011)
      Technologies that rapidly isolate viable single cells from heterogeneous solutions have significantly contributed to the field of medical genomics. Challenges remain both to enable efficient extraction, isolation and ...
    • Engineering Anisotropic Biomimetic Fibrocartilage Microenvironment by Bioprinting Mesenchymal Stem Cells in Nanoliter Gel Droplets 

      Gurkan, Umut A.; El Assal, Rami; Yildiz, Simin E.; Sung, Yuree; Trachtenberg, Alexander J.; Kuo, Winston P.; Demirci, Utkan (American Chemical Society, 2014)
      Over the past decade, bioprinting has emerged as a promising patterning strategy to organize cells and extracellular components both in two and three dimensions (2D and 3D) to engineer functional tissue mimicking constructs. ...
    • Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications 

      Asghar, Waseem; Yuksekkaya, Mehmet; Shafiee, Hadi; Zhang, Michael; Ozen, Mehmet O.; Inci, Fatih; Kocakulak, Mustafa; Demirci, Utkan (Nature Publishing Group, 2016)
      Although materials and engineered surfaces are broadly utilized in creating assays and devices with wide applications in diagnostics, preservation of these immuno-functionalized surfaces on microfluidic devices remains a ...
    • Enumeration of CD4+ T-Cells Using a Portable Microchip Count Platform in Tanzanian HIV-Infected Patients 

      Moon, SangJun; Gurkan, Umut; Blander, Jeffrey; Fawzi, Wafaie W.; Aboud, Said; Mugusi, Ferdinand; Kuritzkes, Daniel Robert; Demirci, Utkan (Public Library of Science (PLoS), 2011)
      Background CD4+ T-lymphocyte count (CD4 count) is a standard method used to monitor HIV-infected patients during anti-retroviral therapy (ART). The World Health Organization (WHO) has pointed out or recommended that a ...
    • Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care 

      Wang, Shuqi; Zhao, Xiaohu; Khimji, Imran; Akbas, Ragip; Qiu, Weiliang; Edwards, Dale; Cramer, Daniel William; Ye, Bin; Demirci, Utkan (Royal Society of Chemistry (RSC), 2011)
      Ovarian cancer is asymptomatic at early stages and most patients present with advanced levels of disease. Lack of cost-effective methods that can achieve frequent, simple and non-invasive testing hinders early detection ...
    • Living Bacterial Sacrificial Porogens to Engineer Decellularized Porous Scaffolds 

      Xu, Feng; Sridharan, BanuPriya; Durmus, Naside Gozde; Wang, Shuqi; Yavuz, Ahmet Sinan; Gurkan, Umut Atakan; Demirci, Utkan (Public Library of Science, 2011)
      Decellularization and cellularization of organs have emerged as disruptive methods in tissue engineering and regenerative medicine. Porous hydrogel scaffolds have widespread applications in tissue engineering, regenerative ...
    • Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care 

      Wang, ShuQi; Tasoglu, Savas; Chen, Paul Z.; Chen, Michael; Akbas, Ragip; Wach, Sonya; Ozdemir, Cenk Ibrahim; Gurkan, Umut Atakan; Giguel, Francoise F.; Kuritzkes, Daniel R.; Demirci, Utkan (Nature Publishing Group, 2014)
      HIV has become one of the most devastating pathogens in human history. Despite fast progress in HIV-related basic research, antiretroviral therapy (ART) remains the most effective method to save AIDS patients' lives. ...
    • Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement 

      Shafiee, Hadi; Lidstone, Erich A.; Jahangir, Muntasir; Inci, Fatih; Hanhauser, Emily; Henrich, Timothy J.; Kuritzkes, Daniel R.; Cunningham, Brian T.; Demirci, Utkan (Nature Publishing Group, 2014)
      Detecting and quantifying biomarkers and viruses in biological samples have broad applications in early disease diagnosis and treatment monitoring. We have demonstrated a label-free optical sensing mechanism using ...
    • Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets 

      Shafiee, Hadi; Asghar, Waseem; Inci, Fatih; Yuksekkaya, Mehmet; Jahangir, Muntasir; Zhang, Michael H.; Durmus, Naside Gozde; Gurkan, Umut Atakan; Kuritzkes, Daniel R.; Demirci, Utkan (Nature Publishing Group, 2015)
      The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, ...
    • Portable Microfluidic Chip for Detection of Escherichia coli in Produce and Blood 

      Wang, Shuqi; Inci, Fatih; Chaunzwa, Tafadzwa L; Ramanujam, Ajay; Vasudevan, Aishwarya; Subramanian, Sathya; Chi Fai Ip, Alexander; Sridharan, Banupriya; Gurkan, Umut Atakan; Demirci, Utkan (Dove Medical Press, 2012)
      Pathogenic agents can lead to severe clinical outcomes such as food poisoning, infection of open wounds, particularly in burn injuries and sepsis. Rapid detection of these pathogens can monitor these infections in a timely ...
    • Portable Microfluidic Integrated Plasmonic Platform for Pathogen Detection 

      Tokel, Onur; Yildiz, Umit Hakan; Inci, Fatih; Durmus, Naside Gozde; Ekiz, Okan Oner; Turker, Burak; Cetin, Can; Rao, Shruthi; Sridhar, Kaushik; Natarajan, Nalini; Shafiee, Hadi; Dana, Aykutlu; Demirci, Utkan (Nature Publishing Group, 2015)
      Timely detection of infectious agents is critical in early diagnosis and treatment of infectious diseases. Conventional pathogen detection methods, such as enzyme linked immunosorbent assay (ELISA), culturing or polymerase ...
    • Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva 

      Shafiee, Hadi; Kanakasabapathy, Manoj Kumar; Juillard, Franceline; Keser, Mert; Sadasivam, Magesh; Yuksekkaya, Mehmet; Hanhauser, Emily; Henrich, Timothy J.; Kuritzkes, Daniel R.; Kaye, Kenneth M.; Demirci, Utkan (Nature Publishing Group, 2014)
      We report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. Point-of-care (POC) viral load measurement is of paramount importance ...
    • Sheathless Size-Based Acoustic Particle Separation 

      Guldiken, Rasim; Jo, Myeong Chan; Gallant, Nathan D.; Demirci, Utkan; Zhe, Jiang (Molecular Diversity Preservation International (MDPI), 2012)
      Particle separation is of great interest in many biological and biomedical applications. Flow-based methods have been used to sort particles and cells. However, the main challenge with flow based particle separation systems ...
    • Simple filter microchip for rapid separation of plasma and viruses from whole blood 

      Wang, Shuqi; Sarenac, Dusan; Chen, Michael; Huang, Shih-Han; Giguel, Francoise F; Kuritzkes, Daniel Robert; Demirci, Utkan (Dove Medical Press, 2012)
      Sample preparation is a significant challenge for detection and sensing technologies, since the presence of blood cells can interfere with the accuracy and reliability of virus detection at the nanoscale for point-of-care ...