Now showing items 1-12 of 12

    • Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice 

      Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Nature Publishing Group, 2014)
      Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity, and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients ...
    • Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation 

      Dong, Yuanlin; Xu, Zhipeng; Wu, Xu; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2012)
      Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of ...
    • Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons 

      Zimering, Jeffrey H.; Dong, Yuanlin; Fang, Fang; Huang, Lining; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2016)
      Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding ...
    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...
    • Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice 

      Zhang, Yiying; Shao, Haijun; Dong, Yuanlin; Swain, Celeste A; Yu, Buwei; Xia, Weiming; Xie, Zhongcong (BioMed Central, 2014)
      Alzheimer’s disease (AD) is the most common form of dementia. At the present time, however, AD still lacks effective treatments. Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain ...
    • Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons 

      Zhang, Yiying; Pan, Chuxiong; Wu, Xu; Dong, Yuanlin; Culley, Deborah J.; Crosby, Gregory; Li, Tianzuo; Xie, Zhongcong (Frontiers Media S.A., 2014)
      Commonly used anesthetic isoflurane has been reported to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase-3 activation. However, the up-stream mechanisms of isoflurane’s effects remain largely to be ...
    • Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice 

      Xu, Zhipeng; Dong, Yuanlin; Wang, Hui; Culley, Deborah J.; Marcantonio, Edward R.; Crosby, Gregory; Tanzi, Rudolph E.; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2014)
      Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to ...
    • The potential dual effects of sevoflurane on AKT/GSK3β signaling pathway 

      Zhang, Lei; Zhang, Jie; Dong, Yuanlin; Swain, Celeste A; Zhang, Yiying; Xie, Zhongcong (BioMed Central, 2014)
      Background: Anesthesia with multiple exposures of commonly used inhalation anesthetic sevoflurane induces neuroinflammation and cognitive impairment in young mice, but anesthesia with a single exposure to sevoflurane does ...
    • Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium 

      Xie, Zhongcong; Swain, Celeste A; Ward, Sarah A P; Zheng, Hui; Dong, Yuanlin; Sunder, Neelakantan; Burke, Dennis W; Escobar, Diana; Zhang, Yiying; Marcantonio, Edward R (BlackWell Publishing Ltd, 2014)
      Objective: The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) β-amyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease. We, therefore, assessed ...
    • Propofol and Magnesium Attenuate Isoflurane-Induced Caspase-3 Activation via Inhibiting Mitochondrial Permeability Transition Pore 

      Zhang, Yiying; Dong, Yuanlin; Xu, Zhipeng; Xie, Zhongcong (BioMed Central, 2012)
      Background: The inhalation anesthetic isoflurane has been shown to open the mitochondrial permeability transition pore (mPTP) and induce caspase activation and apoptosis, which may lead to learning and memory impairment. ...
    • Surgery plus anesthesia induces loss of attention in mice 

      Ren, Quan; Peng, Mian; Dong, Yuanlin; Zhang, Yiying; Chen, Ming; Yin, Ning; Marcantonio, Edward R.; Xie, Zhongcong (Frontiers Media S.A., 2015)
      There is a need to develop animal models to study postoperative delirium. Inattention is one of the symptoms of delirium. Increases in the levels of α-synuclein and S100β have been reported to be associated with delirium. ...
    • Time-Dependent Effects of Anesthetic Isoflurane on Reactive Oxygen Species Levels in HEK-293 Cells 

      Sun, Yongxing; Cheng, Baiqi; Dong, Yuanlin; Li, Tianzuo; Xie, Zhongcong; Zhang, Yiying (MDPI, 2014)
      The inhalation anesthetic isoflurane has been reported to induce caspase activation and apoptosis, which may lead to learning and memory impairment. However, the underlying mechanisms of these effects are largely unknown. ...