Browsing by Author "Wessling-resnick, Marianne"

Now showing items 1-8 of 8

    • Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis 

      Kim, Jonghan; Buckett, Peter D.; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Both iron and manganese absorption are regulated by iron status, ...

    • Distribution of manganese and other biometals in flatiron mice 

      Seo, Young Ah; Elkhader, Jamal A.; Wessling-Resnick, Marianne (Springer Netherlands, 2015)
      Flatiron (ffe) mice display features of “ferroportin disease” or Type IV hereditary hemochromatosis. While it is known that both Fe and Mn metabolism are impaired in flatiron mice, the effects of ferroportin (Fpn) deficiency ...

    • Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo 

      Byrne, Shaina L.; Buckett, Peter D.; Kim, Jonghan; Luo, Flora; Sanford, Jack; Chen, Juxing; Enns, Caroline; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another ...

    • Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring 

      Molina, Ramon M.; Phattanarudee, Siripan; Kim, Jonghan; Thompson, Khristy J.; Wessling-Resnick, Marianne; Maher, Timothy Richard; Brain, Joseph David (Elsevier BV, 2011)
      Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn ...

    • Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency 

      Kim, Jonghan; Li, Yuan; Buckett, Peter D.; Böhlke, Mark; Thompson, Khristy J.; Takahashi, Masaya; Maher, Timothy J.; Wessling-Resnick, Marianne (Public Library of Science, 2012)
      Iron-responsive manganese uptake is increased in iron-deficient rats, suggesting that toxicity related to manganese exposure could be modified by iron status. To explore possible interactions, the distribution of ...

    • Pathophysiology of the Belgrade rat 

      Veuthey, Tania; Wessling-Resnick, Marianne (Frontiers Media S.A., 2014)
      The Belgrade rat is an animal model of divalent metal transporter 1 (DMT1) deficiency. This strain originates from an X-irradiation experiment first reported in 1966. Since then, the Belgrade rat’s pathophysiology has ...

    • Regulation of divalent metal transporter-1 by serine phosphorylation 

      Seo, Young Ah; Kumara, Ruvin; Wetli, Herbert; Wessling-Resnick, Marianne (Portland Press Ltd., 2016)
      Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome. Here, we report that classical cannabinoids ...

    • The Role of Nutrient Sensing in Macrophage Polarization 

      Covarrubias, Anthony Joseph (2016-01-26)
      Macrophages are essential immune cells that belong to the innate immune system and are key orchestrators in the initiation and resolution stages of inflammation. Macrophages are found in every organ throughout the body ...