Now showing items 1-8 of 8

    • Automatic Prediction of Rheumatoid Arthritis Disease Activity from the Electronic Medical Records 

      Lin, Chen; Karlson, Elizabeth W.; Canhao, Helena; Miller, Timothy A.; Dligach, Dmitriy; Chen, Pei Jun; Perez, Raul Natanael Guzman; Shen, Yuanyan; Weinblatt, Michael E.; Shadick, Nancy A.; Plenge, Robert M.; Savova, Guergana K. (Public Library of Science, 2013)
      Objective: We aimed to mine the data in the Electronic Medical Record to automatically discover patients' Rheumatoid Arthritis disease activity at discrete rheumatology clinic visits. We cast the problem as a document ...
    • Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis 

      Sieberts, Solveig K.; Zhu, Fan; García-García, Javier; Stahl, Eli; Pratap, Abhishek; Pandey, Gaurav; Pappas, Dimitrios; Aguilar, Daniel; Anton, Bernat; Bonet, Jaume; Eksi, Ridvan; Fornés, Oriol; Guney, Emre; Li, Hongdong; Marín, Manuel Alejandro; Panwar, Bharat; Planas-Iglesias, Joan; Poglayen, Daniel; Cui, Jing; Falcao, Andre O.; Suver, Christine; Hoff, Bruce; Balagurusamy, Venkat S. K.; Dillenberger, Donna; Neto, Elias Chaibub; Norman, Thea; Aittokallio, Tero; Ammad-ud-din, Muhammad; Azencott, Chloe-Agathe; Bellón, Víctor; Boeva, Valentina; Bunte, Kerstin; Chheda, Himanshu; Cheng, Lu; Corander, Jukka; Dumontier, Michel; Goldenberg, Anna; Gopalacharyulu, Peddinti; Hajiloo, Mohsen; Hidru, Daniel; Jaiswal, Alok; Kaski, Samuel; Khalfaoui, Beyrem; Khan, Suleiman Ali; Kramer, Eric R.; Marttinen, Pekka; Mezlini, Aziz M.; Molparia, Bhuvan; Pirinen, Matti; Saarela, Janna; Samwald, Matthias; Stoven, Véronique; Tang, Hao; Tang, Jing; Torkamani, Ali; Vert, Jean-Phillipe; Wang, Bo; Wang, Tao; Wennerberg, Krister; Wineinger, Nathan E.; Xiao, Guanghua; Xie, Yang; Yeung, Rae; Zhan, Xiaowei; Zhao, Cheng; Calaza, Manuel; Elmarakeby, Haitham; Heath, Lenwood S.; Long, Quan; Moore, Jonathan D.; Opiyo, Stephen Obol; Savage, Richard S.; Zhu, Jun; Greenberg, Jeff; Kremer, Joel; Michaud, Kaleb; Barton, Anne; Coenen, Marieke; Mariette, Xavier; Miceli, Corinne; Shadick, Nancy; Weinblatt, Michael; de Vries, Niek; Tak, Paul P.; Gerlag, Danielle; Huizinga, Tom W. J.; Kurreeman, Fina; Allaart, Cornelia F.; Louis Bridges Jr., S.; Criswell, Lindsey; Moreland, Larry; Klareskog, Lars; Saevarsdottir, Saedis; Padyukov, Leonid; Gregersen, Peter K.; Friend, Stephen; Plenge, Robert; Stolovitzky, Gustavo; Oliva, Baldo; Guan, Yuanfang; Mangravite, Lara M. (Nature Publishing Group, 2016)
      Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies ...
    • Effects of Achieving Target Measures in Rheumatoid Arthritis on Functional Status, Quality of Life, and Resource Utilization: Analysis of Clinical Practice Data 

      Alemao, Evo; Joo, Seongjung; Kawabata, Hugh; Al, Maiwenn J.; Allison, Paul D.; Rutten‐van Mölken, Maureen P. M. H.; Frits, Michelle L.; Iannaccone, Christine K.; Shadick, Nancy A.; Weinblatt, Michael E. (John Wiley and Sons Inc., 2016)
      Objective: To evaluate associations between achieving guideline‐recommended targets of disease activity, defined by the Disease Activity Score in 28 joints using C‐reactive protein level (DAS28‐CRP) <2.6, the Simplified ...
    • An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score 

      Desai, Rishi J; Solomon, Daniel H; Weinblatt, Michael E; Shadick, Nancy; Kim, Seoyoung C (BioMed Central, 2015)
      Introduction: We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated ...
    • Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis 

      Cui, Jing; Stahl, Eli A.; Saevarsdottir, Saedis; Miceli, Corinne; Diogo, Dorothee; Trynka, Gosia; Raj, Towfique; Mirkov, Maša Umiċeviċ; Canhao, Helena; Ikari, Katsunori; Terao, Chikashi; Okada, Yukinori; Wedrén, Sara; Askling, Johan; Yamanaka, Hisashi; Momohara, Shigeki; Taniguchi, Atsuo; Ohmura, Koichiro; Matsuda, Fumihiko; Mimori, Tsuneyo; Gupta, Namrata; Kuchroo, Manik Razdan; Morgan, Ann W.; Isaacs, John D.; Wilson, Anthony G.; Hyrich, Kimme L.; Herenius, Marieke; Doorenspleet, Marieke E.; Tak, Paul-Peter; Crusius, J. Bart A.; van der Horst-Bruinsma, Irene E.; Wolbink, Gert Jan; van Riel, Piet L. C. M.; van de Laar, Mart; Guchelaar, Henk-Jan; Shadick, Nancy Ann; Allaart, Cornelia F.; Huizinga, Tom W. J.; Toes, Rene E. M.; Kimberly, Robert P.; Bridges, S. Louis; Criswell, Lindsey A.; Moreland, Larry W.; Fonseca, João Eurico; de Vries, Niek; Stranger, Barbara E.; De Jager, Philip Lawrence; Raychaudhuri, Soumya; Weinblatt, Michael Elliott; Gregersen, Peter K.; Mariette, Xavier; Barton, Anne; Padyukov, Leonid; Coenen, Marieke J. H.; Karlson, Elizabeth Wood; Plenge, Robert M. (Public Library of Science, 2013)
      Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the ...
    • The Influence of Polygenic Risk Scores on Heritability of Anti-CCP Level in RA 

      Cui, Jing; Taylor, Kimberly E.; Lee, Yvonne C.; Källberg, Henrik; Weinblatt, Michael E.; Coblyn, Jonathan S.; Klareskog, Lars; Criswell, Lindsey A.; Gregersen, Peter K.; Shadick, Nancy A.; Plenge, Robert M.; Karlson, Elizabeth W. (2014)
      Objective: To study genetic factors that influence quantitative anti-cyclic citrullinated peptide (anti-CCP) antibody levels in RA patients. Methods: We carried out a genome wide association study (GWAS) meta-analysis using ...
    • PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis 

      Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Bing; Iannaccone, Christine; Cernadas, Manuela; Weinblatt, Michael Elliott; Shadick, Nancy Ann; Miaw, Shi-Chuen; Ho, I-Cheng (Public Library of Science, 2012)
      PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) ...
    • Sustained rheumatoid arthritis remission is uncommon in clinical practice 

      Prince, Femke HM; Bykerk, Vivian P; Shadick, Nancy Ann; Lu, Bing; Cui, Jing; Frits, Michelle; Iannaccone, Christine K; Weinblatt, Michael Elliott; Solomon, Daniel Hal (BioMed Central, 2012)
      Introduction: Remission is an important goal of therapy in rheumatoid arthritis (RA), but data on duration of remission are lacking. Our objective was to describe the duration of remission in RA, assessed by different ...