Now showing items 1-4 of 4

    • Classical Flt3L-dependent dendritic cells control immunity to protein vaccine 

      Anandasabapathy, Niroshana; Feder, Rachel; Mollah, Shamim; Tse, Sze-Wah; Longhi, Maria Paula; Mehandru, Saurabh; Matos, Ines; Cheong, Cheolho; Ruane, Darren; Brane, Lucas; Teixeira, Angela; Dobrin, Joseph; Mizenina, Olga; Park, Chae Gyu; Meredith, Matthew; Clausen, Björn E.; Nussenzweig, Michel C.; Steinman, Ralph M. (The Rockefeller University Press, 2014)
      DCs are critical for initiating immunity. The current paradigm in vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (cDCs) cooperate in the draining LNs to initiate priming ...
    • Flt3L-dependence helps define an uncharacterized subset of murine cutaneous dendritic cells 

      Mollah, Shamim; Dobrin, Joseph; Feder, Rachel; Tse, Sze-Wah; Matos, Ines; Cheong, Cheolho; Steinman, Ralph M.; Anandasabapathy, Niroshana (2014)
      Skin-derived dendritic cells (DC) are potent antigen presenting cells with critical roles in both adaptive immunity and tolerance to self. Skin DC carry antigens and constitutively migrate to the skin draining lymph nodes ...
    • Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation 

      Papaspyridonos, Marianna; Matei, Irina; Huang, Yujie; do Rosario Andre, Maria; Brazier-Mitouart, Helene; Waite, Janelle C.; Chan, April S.; Kalter, Julie; Ramos, Ilyssa; Wu, Qi; Williams, Caitlin; Wolchok, Jedd D.; Chapman, Paul B.; Peinado, Hector; Anandasabapathy, Niroshana; Ocean, Allyson J.; Kaplan, Rosandra N.; Greenfield, Jeffrey P.; Bromberg, Jacqueline; Skokos, Dimitris; Lyden, David (Nature Pub. Group, 2015)
      A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive ‘macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the ...
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor 

      Rothhammer, Veit; Mascanfroni, Ivan D.; Bunse, Lukas; Takenaka, Maisa C.; Kenison, Jessica E.; Mayo, Lior; Chao, Chun-Cheih; Patel, Bonny; Yan, Raymond; Blain, Manon; Alvarez, Jorge I.; Kébir, Hania; Anandasabapathy, Niroshana; Izquierdo, Guillermo; Jung, Steffen; Obholzer, Nikolaus; Pochet, Nathalie; Clish, Clary B.; Prinz, Marco; Prat, Alexandre; Antel, Jack; Quintana, Francisco J. (2016)
      Astrocytes play important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-I) in astrocytes during experimental ...