Browsing by Author "Lim, Bing"
Now showing items 1-6 of 6
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B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells
Tarasov, Kirill V.; Tarasova, Yelena S.; Tam, Wai Leong; Riordon, Daniel R.; Elliott, Steven T.; Kania, Gabriela; Li, Jinliang; Yamanaka, Satoshi; Crider, David G.; Testa, Gianluca; Li, Ronald A.; Stewart, Colin L.; Liu, Yie; Van Eyk, Jennifer E.; Wersto, Robert P.; Wobus, Anna M.; Boheler, Kenneth R.; Lim, Bing (Public Library of Science, 2008)Background: The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype ... -
Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions
Lee, Kian Leong; Lim, Sandy Keat; Orlov, Yuriy Lvovich; Yit, Le Yau; Yang, Henry; Poellinger, Lorenz; Lim, Bing; Ang, Lay Teng (Public Library of Science, 2011)Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin ... -
MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity
Xie, Huangming; Lim, Bing; Lodish, Harvey F. (American Diabetes Association, 2009)OBJECTIVE-- We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity. RESEARCH DESIGN AND METHODS- Using miRNA microarrays, we profiled the expression of >370 miRNAs during ... -
PI3 K/Akt/mTOR-Mediated Translational Control Regulates Proliferation and Differentiation of Lineage-Restricted RoSH Stem Cell Lines
Que, Jianwen; Lian, Qizhou; El Oakley, Reida M; Lim, Sai-Kiang; Lim, Bing (BioMed Central, 2007)Background: We have previously derived highly similar lineage-restricted stem cell lines, RoSH and E-RoSH cell lines from mouse embryos and CD9hi SSEA-1- differentiated mouse embryonic stem cells, respectively. These cell ... -
Reconstitution of Mammary Epithelial Morphogenesis by Murine Embryonic Stem Cells Undergoing Hematopoietic Stem Cell Differentiation
Lee, Byeong-Chel; Jiang, Shuxian; Fu, Yigong; Avraham, Shalom; Lim, Bing; Avraham, Hava (Public Library of Science, 2010)Background: Mammary stem cells are maintained within specific microenvironments and recruited throughout lifetime to reconstitute de novo the mammary gland. Mammary stem cells have been isolated through the identification ... -
Zfp36l2 is required for self-renewal of early erythroid BFU-E progenitors
Zhang, Lingbo; Prak, Lina; Rayon-Estrada, Violeta; Thiru, Prathapan; Flygare, Johan; Lim, Bing; Lodish, Harvey F. (2013)Stem cells and progenitors in many lineages undergo self- renewing divisions, but the extracellular and intracellular proteins that regulate this process are largely unknown. Glucocorticoids stimulate red cell formation ...