Now showing items 1-20 of 21

    • A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis 

      Klein, Joshua Peter; Arora, A.; Neema, M; Healy, Brian Curran; Tauhid, Shahamat Syed; Goldberg-Zimring, D.; Chavarro-Nieto, C.; Stankiewicz, James; Cohen, Adam Brian; Buckle, G. J.; Houtchens, Maria K.; Ceccarelli, A.; Dell, E.; Guttmann, Charles R.G.; Alsop, David C.; Hackney, David Brian; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2011)
      Background and Purpose: Spinal cord atrophy is a common feature of MS. However, it is unknown which cord levels are most susceptible to atrophy. We performed whole cord imaging to identify the levels most susceptible to ...
    • Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis 

      Healy, Brian Curran; Engler, David; Glanz, Bonnie; Musallam, Alexander; Chitnis, Tanuja (Hindawi Publishing Corporation, 2013)
      Sustained progression on the expanded disability status scale (EDSS) is a common outcome measure of disease progression in clinical studies of MS. Unfortunately, this outcome may not accurately measure long-term and ...
    • Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis 

      Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)
      Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ...
    • Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis 

      Tauhid, Shahamat; Chu, Renxin; Sasane, Rahul; Glanz, Bonnie I.; Neema, Mohit; Miller, Jennifer R.; Kim, Gloria; Signorovitch, James E.; Healy, Brian C.; Chitnis, Tanuja; Weiner, Howard L.; Bakshi, Rohit (Springer Berlin Heidelberg, 2015)
      Multiple sclerosis (MS) commonly affects occupational function. We investigated the link between brain MRI and employment status. Patients with MS (n = 100) completed a Work Productivity and Activity Impairment (WPAI) ...
    • Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis 

      Regev, Keren; Paul, Anu; Healy, Brian; von Glenn, Felipe; Diaz-Cruz, Camilo; Gholipour, Taha; Mazzola, Maria Antonietta; Raheja, Radhika; Nejad, Parham; Glanz, Bonnie I.; Kivisakk, Pia; Chitnis, Tanuja; Weiner, Howard L.; Gandhi, Roopali (Lippincott Williams & Wilkins, 2016)
      Objective: To identify circulating microRNAs (miRNAs) linked to disease stage and disability in multiple sclerosis (MS). Methods: Sera from 296 participants including patients with MS, other neurologic diseases (Alzheimer ...
    • The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis 

      Yousuf, Fawad; Kim, Gloria; Tauhid, Shahamat; Glanz, Bonnie I.; Chu, Renxin; Tummala, Subhash; Healy, Brian C.; Bakshi, Rohit (Frontiers Media S.A., 2016)
      Objective: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). ...
    • The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis 

      Dupuy, Sheena L.; Khalid, Fariha; Healy, Brian C.; Bakshi, Sonya; Neema, Mohit; Tauhid, Shahamat; Bakshi, Rohit (BioMed Central, 2016)
      Background: Spinal cord atrophy occurs early in multiple sclerosis (MS) and impacts disability. The therapeutic effect of interferon beta-1a (IFNβ-1a) on spinal cord atrophy in patients with relapsing-remitting (RR) MS has ...
    • Evaluation of an Online Platform for Multiple Sclerosis Research: Patient Description, Validation of Severity Scale, and Exploration of BMI Effects on Disease Course 

      Musallam, Alexander; Vaughan, Timothy; Wicks, Paul; Bove, Riley Marie; Secor, Elizabeth; Healy, Brian Curran; Glanz, Bonnie; Greeke, Emily Elizabeth; Weiner, Howard Lee; Chitnis, Tanuja; De Jager, Philip Lawrence (Public Library of Science, 2013)
      Objectives: To assess the potential of an online platform, PatientsLikeMe.com (PLM), for research in multiple sclerosis (MS). An investigation of the role of body mass index (BMI) on MS disease course was conducted to ...
    • Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models 

      Chua, Alicia S.; Egorova, Svetlana; Anderson, Mark C.; Polgar-Turcsanyi, Mariann; Chitnis, Tanuja; Weiner, Howard L.; Guttmann, Charles R.G.; Bakshi, Rohit; Healy, Brian C. (Elsevier, 2015)
      Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the ...
    • Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging 

      Mike, A.; Glanz, Bonnie; Hildenbrand, Peter G.; Meier, D; Bolden, K.; Liguori, M.; Dell, E.; Healy, Brian Curran; Bakshi, Rohit; Guttmann, Charles R.G. (American Society of Neuroradiology (ASNR), 2011)
      Background and Purpose: Histopathologic studies have reported widespread cortical lesions in MS; however, in vivo detection by using routinely available pulse sequences is challenging. We investigated the relative frequency ...
    • IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production 

      Maier, Lisa M.; Lowe, Christopher E.; Downes, Kate; Clark, Pamela M.; Walker, Neil; Aubin, Cristin; Oksenberg, Jorge R.; Hauser, Stephen L.; Compston, Alistair; Sawcer, Stephen; Wicker, Linda S.; Cooper, Jason S; Anderson, David E.; Severson, Christopher; Healy, Brian Curran; The International Multiple Sclerosis Genetics Consortium; De Jager, Philip Lawrence; Todd, John A.; Hafler, David A. (Public Library of Science, 2009)
      Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex ...
    • MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis 

      Tauhid, Shahamat Syed; Neema, Mohit; Healy, Brian Curran; Weiner, Howard Lee; Bakshi, Rohit (Elsevier BV, 2014)
      Background: While disease categories (i.e. clinical phenotypes) of multiple sclerosis (MS) are established, there remains MRI heterogeneity among patients within those definitions. MRI-defined lesions and atrophy show only ...
    • An MRI-defined measure of cerebral lesion severity to assess therapeutic effects in multiple sclerosis 

      Kim, Gloria; Tauhid, Shahamat; Dupuy, Sheena L.; Tummala, Subhash; Khalid, Fariha; Healy, Brian C.; Bakshi, Rohit (Springer Berlin Heidelberg, 2016)
      Assess the sensitivity of the Magnetic Resonance Disease Severity Scale (MRDSS), based on cerebral lesions and atrophy, for treatment monitoring of glatiramer acetate (GA) in relapsing-remitting multiple sclerosis (MS). ...
    • No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50 

      Bove, Riley; Musallam, Alexander; Healy, Brian C; Houtchens, Maria; Glanz, Bonnie I; Khoury, Samia; Guttmann, Charles R; De Jager, Philip L; Chitnis, Tanuja (BioMed Central, 2013)
      Background: The disease course in multiple sclerosis (MS) is influenced by many factors, including age, sex, and sex hormones. Little is known about sex-specific changes in disease course around age 50, which may represent ...
    • Normal Findings on Brain Fluid-Attenuated Inversion Recovery MR Images at 3T 

      Neema, M; Guss, Z.D.; Stankiewicz, James; Arora, A; Healy, Brian Curran; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2009)
      Background and Purpose: Fluid attenuated inversion recovery (FLAIR) MR imaging of the brain has become a routine tool for assessing lesions in patients with suspected neurologic disorders. There is growing interest in 3T ...
    • Quantification of Global Cerebral Atrophy in Multiple Sclerosis from 3T MRI Using SPM: The Role of Misclassification Errors 

      Dell’Oglio, Elisa; Ceccarelli, Antonia; Glanz, Bonnie I; Healy, Brian C; Tauhid, Shahamat; Arora, Ashish; Saravanan, Nikila; Bruha, Matthew J; Vartanian, Alexander V; Dupuy, Sheena L; Benedict, Ralph HB; Bakshi, Rohit; Neema, Mohit (BlackWell Publishing Ltd, 2014)
      Purpose We tested the validity of a freely available segmentation pipeline to measure compartmental brain volumes from 3T MRI in patients with multiple sclerosis (MS). Our primary focus was methodological to explore the ...
    • Quantitative MRI Phenotypes in Longitudinal Population of MS Patients. 

      Egorova, Svetlana; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Healy, Brian Curran; Weiner, Howard Lee (2014)
    • Quantitative MRI study of Pineal Gland in MS. 

      Egorova, Svetlana; Denes, Palma; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Cavallari, Michele; Guttmann, Charles R.G.; Glanz, Bonnie; Chitnis, Tanuja; Bove, Riley; Buckle, Guy; De Jager, Philip Lawrence; Severson, Cristopher; Stankiewicz, James; Houtchens, Maria K.; Quintana, Francisco Javier; Gandhi, Roopali; Webb, Pia; Meier, Dominik; Healy, Brian Curran; Weiner, Howard Lee (2016)
    • Reserve and Reserve-building activities research: key challenges and future directions 

      Schwartz, Carolyn E.; Rapkin, Bruce D.; Healy, Brian C. (BioMed Central, 2016)
      Background: The concept of Cognitive Reserve has great appeal and has led to an interesting and important body of research. We believe, however, that it is unnecessarily limited by ‘habits’ of measurement, nomenclature, ...
    • T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis 

      Kim, Gloria; Khalid, Fariha; Oommen, Vinit V.; Tauhid, Shahamat; Chu, Renxin; Horsfield, Mark A.; Healy, Brian C.; Bakshi, Rohit (BioMed Central, 2015)
      Background: The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). Methods: We compared T1- and T2-weighted MRI for measuring ...