Now showing items 1-3 of 3

    • IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection 

      Chan, Ying Kai; Huang, I-Chueh; Farzan, Michael (Public Library of Science, 2012)
      Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via ...
    • Interplay of Dengue Virus and the Human Immune Response 

      Chan, Ying Kai (2015-05-07)
      RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to ...
    • TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine 

      Jemielity, Stephanie; Wang, Jinyize J.; Chan, Ying Kai; Ahmed, Asim Aminsharif; Li, Wenhui; Monahan, Sheena; Bu, Xia; Farzan, Michael; Freeman, Gordon James; Umetsu, Dale T.; DeKruyff, Rosemarie H.; Choe, Hyeryun (Public Library of Science, 2013)
      Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and ...