Now showing items 1-15 of 15

    • 3-dimensional digital reconstruction of the murine coronary system for the evaluation of chronic allograft vasculopathy 

      Fónyad, László; Shinoda, Kazunobu; Farkash, Evan A; Groher, Martin; Sebastian, Divya P; Szász, A Marcell; Colvin, Robert B; Yagi, Yukako (BioMed Central, 2015)
      Background: Chronic allograft vasculopathy (CAV) is a major mechanism of graft failure of transplanted organs in humans. Morphometric analysis of coronary arteries enables the quantitation of CAV in mouse models of heart ...
    • Balancing Image Quality and Compression Factor for Special Stains Whole Slide Images 

      Sharma, Anurag; Bautista, Pinky; Yagi, Yukako (IOS Press, 2012)
      The objective is to find a practical balance between quality and performance for daily high volume whole slide imaging. We evaluated whole slide images created by various scanners at different compression factors to determine ...
    • Color Standardization and Optimization in Whole Slide Imaging 

      Yagi, Yukako (BioMed Central, 2011)
      Introduction: Standardization and validation of the color displayed by digital slides is an important aspect of digital pathology implementation. While the most common reason for color variation is the variance in the ...
    • Consistency and Standardization of Color in Medical Imaging: a Consensus Report 

      Badano, Aldo; Revie, Craig; Casertano, Andrew; Cheng, Wei-Chung; Green, Phil; Kimpe, Tom; Krupinski, Elizabeth; Sisson, Christye; Skrøvseth, Stein; Treanor, Darren; Boynton, Paul; Clunie, David; Flynn, Michael J.; Heki, Tatsuo; Hewitt, Stephen; Homma, Hiroyuki; Masia, Andy; Matsui, Takashi; Nagy, Balázs; Nishibori, Masahiro; Penczek, John; Schopf, Thomas; Yagi, Yukako; Yokoi, Hideto (Springer US, 2014)
      This article summarizes the consensus reached at the Summit on Color in Medical Imaging held at the Food and Drug Administration (FDA) on May 8–9, 2013, co-sponsored by the FDA and ICC (International Color Consortium). The ...
    • The Importance of Optical Optimization in Whole Slide Imaging (WSI) and Digital Pathology Imaging 

      Yagi, Yukako; Gilbertson, John R (BioMed Central, 2008)
      In the last 10 years, whole slide imaging (WSI) has seen impressive progress not only in image quality and scanning speed but also in the variety of systems available to pathologists. However, we have noticed that most ...
    • Localization of Eosinophilic Esophagitis from H&E Stained Images Using Multispectral Imaging 

      Bautista, Pinky Abarca; Yagi, Yukako (BioMed Central, 2011)
      This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin ...
    • Mitotic Figure Recognition: Agreement among Pathologists and Computerized Detector 

      Malon, Christopher; Brachtel, Elena; Cosatto, Eric; Graf, Hans Peter; Kurata, Atsushi; Kuroda, Masahiko; Meyer, John S.; Saito, Akira; Wu, Shulin; Yagi, Yukako (IOS Press, 2012)
      Despite the prognostic importance of mitotic count as one of the components of the Bloom – Richardson grade [3], several studies ([2, 9, 10]) have found that pathologists’ agreement on the mitotic grade is fairly modest. ...
    • Multispectral Enhancement Method to Increase the Visual Differences of Tissue Structures in Stained Histopathology Images 

      Bautista, Pinky A.; Yagi, Yukako (IOS Press, 2012)
      In this paper we proposed a multispectral enhancement scheme in which the spectral colors of the stained tissue-structure of interest and its background can be independently modified by the user to further improve their ...
    • Multispectral Enhancement towards Digital Staining 

      Bautista, Pinky A.; Yagi, Yukako (IOS Press, 2012)
      Background:: Digital staining can be considered as a special form of image enhancement wherein the concern is not only to increase the contrast between the background objects and objects of interest, but to also impart the ...
    • Optical Endomicroscopy and the Road to Real-Time, In Vivo Pathology: Present and Future 

      Carignan, Charles S; Yagi, Yukako (BioMed Central, 2012)
      Epithelial cancers account for substantial mortality and are an important public health concern. With the need for earlier detection and treatment of these malignancies, the ability to accurately detect precancerous lesions ...
    • Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens 

      Sarraj, WafaM; Tang, Rong; Najjar, Anas L; Griffin, Molly; Bui, Anthony H; Zambeli-Ljepovic, Alan; Senter-Zapata, Mike; Lewin-Berlin, Maya; Fernandez, Leopoldo; Buckley, Juliette; Ly, Amy; Brachtel, Elena F.; Aftreth, Owen; Gilbertson, John R; Yagi, Yukako; Gadd, Michele Annette; Hughes, Kevin S.; Smith, BarbaraL; Michaelson, JamesS (Medknow, 2015)
      Background: Histopathology is the only accepted method to measure and stage the breast tumor size. However, there is a need to find another method to measure and stage the tumor size when the pathological assessment is not ...
    • Reflectance Confocal Microscopy for the Diagnosis of Eosinophilic Esophagitis: a Pilot Study Conducted on Biopsy Specimens 

      Yoo, Hongki; Kang, DongKyun; Katz, Aubrey J.; Lauwers, Gregory Y.; Nishioka, Norman Shizuaki; Yagi, Yukako; Tanpowpong, Pornthep; Namati, Jacqueline; Bouma, Brett; Tearney, Guillermo James (Elsevier BV, 2011)
      Background: Diagnosis of eosinophilic esophagitis (EoE) currently requires endoscopic biopsy and histopathologic analysis of the biopsy specimens to count intraepithelial eosinophils. Reflectance confocal microscopy (RCM) ...
    • A Relationship Between Slide Quality and Image Quality in Whole Slide Imaging (WSI) 

      Yagi, Yukako; Gilbertson, John R (BioMed Central, 2008)
      This study examined the effect of tissue section thickness and consistency – parameters outside the direct control of the imaging devices themselves – on WSI capture speed and image quality. Preliminary data indicates that ...
    • A Role of Three-Dimensional (3D)-Reconstruction in the Classification of Lung Adenocarcinoma 

      Onozato, Maristela L.; Klepeis, Veronica E.; Yagi, Yukako; Mino-Kenudson, Mari (IOS Press, 2012)
      Background:: Three-dimensional (3D)-reconstruction from paraffin embedded sections has been considered laborious and time-consuming. However, the high-resolution images of large object areas and different fields of view ...
    • An Ultra-High Speed Whole Slide Image Viewing System 

      Yagi, Yukako; Yoshioka, Shigeatsu; Kyusojin, Hiroshi; Onozato, Maristela; Mizutani, Yoichi; Osato, Kiyoshi; Yada, Hiroaki; Mark, Eugene J.; Frosch, Matthew P.; Louis, David N. (IOS Press, 2012)
      Background:: One of the goals for a Whole Slide Imaging (WSI) system is implementation in the clinical practice of pathology. One of the unresolved problems in accomplishing this goal is the speed of the entire process, ...