Now showing items 1-3 of 3

    • Context influences on TALE–DNA binding revealed by quantitative profiling 

      Rogers, Julia M.; Barrera, Luis A.; Reyon, Deepak; Sander, Jeffry D.; Kellis, Manolis; Joung, J Keith; Bulyk, Martha L. (Nature Pub. Group, 2015)
      Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in genome engineering technologies that require precise targeting. Although ...
    • DNA-Binding Specificity Changes in the Evolution of Forkhead Transcription Factors 

      Nakagawa, So; Gisselbrecht, Stephen; Rogers, Julia Maria; Hartl, Daniel L.; Bulyk, Martha Leonia (Proceedings of the National Academy of Sciences, 2013)
      The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ...
    • Structure of a pseudokinase domain switch that controls oncogenic activation of Jak kinases 

      Toms, Angela V.; Deshpande, Anagha; McNally, Randall; Jeong, Youngjee; Rogers, Julia M.; Kim, Chae Un; Gruner, Sol M.; Ficarro, Scott B.; Marto, Jarrod A.; Sattler, Martin; Griffin, James D.; Eck, Michael J. (2013)
      The V617F mutation in the Jak2 pseudokinase domain causes myeloproliferative neoplasms, and the equivalent mutation in Jak1 (V658F) is found in T-cell leukemias. Crystal structures of wild type and V658F mutant human Jak1 ...