Now showing items 1-4 of 4

    • Astrocytes in the optic nerve head express putative mechanosensitive channels 

      Choi, Hee Joo; Sun, Daniel; Jakobs, Tatjana C. (Molecular Vision, 2015)
      Purpose To establish whether optic nerve head astrocytes express candidate molecules to sense tissue stretch. Methods: We used conventional PCR, quantitative PCR, and single-cell reverse transcription PCR (RT–PCR) to assess ...
    • Organotypic Culture of Physiologically Functional Adult Mammalian Retinas 

      Koizumi, Amane; Zeck, Günther; Ben, Yixin; Masland, Richard Harry; Jakobs, Tatjana Claudia (Public Library of Science, 2007)
      Background: The adult mammalian retina is an important model in research on the central nervous system. Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which ...
    • Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma 

      Berry, Ryan H.; Qu, Juan; John, Simon W. M.; Howell, Gareth R.; Jakobs, Tatjana C. (Public Library of Science, 2015)
      It has been hypothesized that synaptic pruning precedes retinal ganglion cell degeneration in glaucoma, causing early dysfunction to retinal ganglion cells. To begin to assess this, we studied the excitatory synaptic inputs ...
    • The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve 

      Qu, Juan; Jakobs, Tatjana C. (Public Library of Science, 2013)
      Reactive gliosis is a complex process that involves changes in gene expression and morphological remodeling. The mouse optic nerve, where astrocytes, microglia and oligodendrocytes interact with retinal ganglion cell axons ...