Now showing items 1-10 of 10

    • Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia 

      Sigurdsson, Martin I.; Saddic, Louis; Heydarpour, Mahyar; Chang, Tzuu-Wang; Shekar, Prem; Aranki, Sary; Couper, Gregory S.; Shernan, Stanton K.; Seidman, Jon G.; Body, Simon C.; Muehlschlegel, Jochen D. (BioMed Central, 2016)
      Background: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from ...
    • Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk 

      Habchi, Karam M.; undefined, undefined; Ashikhmina, Elena; Vieira, Vanessa Montiero; Shahram, Jasmin T.; Isselbacher, Eric Michael; Sundt, Thoralf M; Shekar, Prem; Muehlschlegel, Jochen Daniel; Body, Simon Christopher (Springer Nature, 2016)
      Thoracic aortic disease, including thoracic aor- tic aneurysm (TAA), is frequently seen in patients with bicuspid aortic valve (BAV). We hypothesized that BAV morphotype would be associated with aortic aneurysm phe- notypes ...
    • C-Reactive Protein Gene Variants Are Associated with Postoperative C-reactive Protein Levels After Coronary Artery Bypass Surgery 

      Perry, Tjörvi E; Muehlschlegel, Jochen Daniel; Liu, Kuang-Yu; Fox, Amanda Arlene; Collard, Charles D; Body, Simon Christopher; Shernan, Stanton K. (BioMed Central, 2009)
      Background: Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ...
    • Duration of Postoperative Atrial Fibrillation After Cardiac Surgery Is Associated With Worsened Long-Term Survival 

      Sigurdsson, Martin I.; Longford, Nicholas T.; Heydarpour, Mahyar; Saddic, Louis; Chang, Tzuu-Wang; Fox, Amanda A.; Collard, Charles D.; Aranki, Sary Fouad; Shekar, Prem; Shernan, Stanton K.; Muehlschlegel, Jochen Daniel; Body, Simon Christopher (Elsevier BV, 2016)
      Background. Studies of the effects of postoperative atrial fibrillation (poAF) on long-term survival are con- flicting, likely because of comorbidities that occur with poAF and the patient populations studied. Furthermore, ...
    • Genetic and Clinical Risk Prediction Model for Postoperative Atrial Fibrillation 

      Kolek, M. J.; Muehlschlegel, Jochen Daniel; Bush, W. S.; Parvez, B.; Murray, K. T.; Stein, C. M.; Shoemaker, M. B.; Blair, M. A.; Kor, K. C.; Roden, D. M.; Donahue, B. S.; Fox, A. A.; Shernan, S. K.; Collard, C. D.; Body, Simon Christopher; Darbar, D. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at the chromosome ...
    • Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery 

      Leaf, David Evan; Body, Simon Christopher; Muehlschlegel, Jochen Daniel; McMahon, Gearoid; Lichtner, P.; Collard, C. D.; Shernan, S. K.; Fox, A. A.; Waikar, Sushrut Subhash (American Society of Nephrology (ASN), 2016)
      Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in the pathogenesis of AKI. Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter inversely associate ...
    • The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle 

      Saddic, Louis A.; Sigurdsson, Martin I.; Chang, Tzuu-Wang; Mazaika, Erica; Heydarpour, Mahyar; Shernan, Stanton K.; Seidman, Christine Edry; Seidman, Jonathan G.; Aranki, Sary Fouad; Body, Simon Christopher; Muehlschlegel, Jochen Daniel (Ovid Technologies (Wolters Kluwer Health), 2017)
      Background—The discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation ...
    • Plasma Corin Decreases After Coronary Artery Bypass Graft Surgery and Is Associated With Postoperative Heart Failure: A Pilot Study 

      Barnet, Caryn S.; Liu, Xiaoxiao; Body, Simon Christopher; Collard, Charles D.; Shernan, Stanton K.; Muehlschlegel, Jochen Daniel; Jarolim, Petr; Fox, Amanda A. (Elsevier BV, 2015)
      Objective: Corin is a natriuretic peptide-converting enzyme that cleaves precursor pro-B-type natriuretic peptide to active B-type natriuretic peptide (BNP) (diuretic, natriuretic, and vaso- dilatory properties). Increased ...
    • Profilin-1 Is Expressed in Human Atherosclerotic Plaques and Induces Atherogenic Effects on Vascular Smooth Muscle Cells 

      Caglayan, Evren; Kappert, Kai; Odenthal, Margarete; Südkamp, Michael; Hackbusch, Daniel; Vantler, Marius; Rosenkranz, Stephan; Romeo, Giulio R.; Body, Simon Christopher; Shernan, Stanton K.; Kazlauskas, Andrius (Public Library of Science, 2010)
      Background: Profilin-1 is an ubiquitous actin binding protein. Under pathological conditions such as diabetes, profilin-1 levels are increased in the vascular endothelium. We recently demonstrated that profilin-1 overexpression ...
    • Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development 

      Yabusaki, Katsumi; Hutcheson, Joshua D.; Vyas, Payal; Bertazzo, Sergio; Body, Simon C.; Aikawa, Masanori; Aikawa, Elena (Frontiers Media S.A., 2016)
      Recent studies indicated that small calcified particles observable by scanning electron microscopy (SEM) may initiate calcification in cardiovascular tissues. We hypothesized that if the calcified particles precede gross ...