Browsing by Author "Lee, David Marvin"
Now showing items 1-4 of 4
-
c-Fms-Mediated Differentiation and Priming of Monocyte Lineage Cells Play a Central Role in Autoimmune Arthritis
Paniagua, Ricardo T; Chang, Anna; Mariano, Melissa M; Stein, Emily A; Lindstrom, Tamsin M; Sharpe, Orr; Roscow, Claire; Ho, Peggy P; Wang, Qian; Lee, David Marvin; Robinson, William H. (BioMed Central, 2010)Introduction: Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA). We previously demonstrated that imatinib mesylate--a Food and Drug Administration (FDA)-approved, ... -
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes
Cloutier, Nathalie; Tan, Sisareuth; Boudreau, Luc H; Cramb, Catriona; Subbaiah, Roopashree; Lahey, Lauren; Albert, Alexandra; Shnayder, Ruslan; Gobezie, Reuben; Nigrovic, Peter Andrija; Farndale, Richard W; Robinson, William H; Brisson, Alain; Lee, David Marvin; Boilard, Eric (WILEY-VCH Verlag, 2013)Immunoglobulins, antigens and complement can assemble to form immune complexes (IC). ICs can be detrimental as they propagate inflammation in autoimmune diseases. Like ICs, submicron extracellular vesicles termed microparticles ... -
Inhibition of Highly Productive HIV-1 Infection in T Cells, Primary Human Macrophages, Microglia, and Astrocytes by Sargassum fusiforme
Paskaleva, Elena E; Lin, Xudong; Cotter, Robin; Klein, Michael T; Roberge, Emily; Yu, Er K; Clark, Bruce; Veille, Jean-Claude; Liu, Yanze; Canki, Mario; Lee, David Marvin; Li, Wen (BioMed Central, 2006)Background: The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown ... -
Lipid Mediators in Innate Immunity Against Tuberculosis: Opposing Roles of PGE2 and LXA4 in the Induction of Macrophage Death
Chen, Minjian; Divangahi, Maziar; Gan, Huixian; Shin, Daniel S.J.; Hong, Song; Lee, David Marvin; Serhan, Charles Nicholas; Behar, Samuel M; Remold, Heinz G (Rockefeller University Press, 2008)Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv ...