Browsing by Author "Ascherio, Alberto"
Now showing items 1-8 of 8
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Dietary and Genetic Risk Factors for Parkinson's Disease
Hughes, Katherine Carlson (2016-04-25)Parkinson’s disease (PD) is the second most common neurodegenerative disease. Motor symptoms typically do not manifest until significant neuronal loss has already occurred, highlighting the need for early detection and ... -
Genome-Wide Association Study of Circulating Vitamin D Levels
Ahn, Jiyoung; Yu, Kai; Stolzenberg-Solomon, Rachael; McCullough, Marjorie L.; Gallicchio, Lisa; Jacobs, Eric J.; Helzlsouer, Kathy; Jacobs, Kevin B.; Li, Qizhai; Weinstein, Stephanie J.; Purdue, Mark; Virtamo, Jarmo; Horst, Ronald; Chanock, Stephen; Hayes, Richard B.; Kraft, Peter; Albanes, Demetrius; Simon, Kelly Claire; Ascherio, Alberto B.; Wheeler, William; Hunter, David J. (Oxford University Press, 2010)The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study ... -
Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies
Song, Mingyang; Everett, Christine; Li, Chengchen; Wilkinson, Jeremy; Nguyen, Long; McIver, Lauren; Ivey, Kerry; Izard, Jacques; Palacios, Natalia; Eliassen, A.; Willett, Walter; Ascherio, Alberto; Sun, Qi; Tworoger, Shelley; Chang, Andrew; Garrett, Wendy; Huttenhower, Curtis; Rimm, Eric; Song, Mingyang (Springer Science and Business Media LLC, 2021-04-21)A lack of prospective studies has been a major barrier for assessing the role of the microbiome in human health and disease on a population-wide scale. To address this significant knowledge gap, we have launched a large-scale ... -
Particulate matter and risk of parkinson disease in a large prospective study of women
Palacios, Natalia; Fitzgerald, Kathryn C; Hart, Jaime E; Weisskopf, Marc G; Schwarzschild, Michael A; Ascherio, Alberto; Laden, Francine (BioMed Central, 2014)Background: Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined ... -
Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses’ Health Study II Participants
Roberts, Andrea L.; Lyall, Kristen; Hart, Jaime E.; Laden, Francine; Just, Allan C.; Bobb, Jennifer F.; Koenen, Karestan C.; Ascherio, Alberto; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2013)Objective: Air pollution contains many toxicants known to affect neurological function and to have effects on the fetus in utero. Recent studies have reported associations between perinatal exposure to air pollutants and ... -
A Prospective Analysis of Airborne Metal Exposures and Risk of Parkinson Disease in the Nurses’ Health Study Cohort
Palacios, Natalia; Fitzgerald, Kathryn; Roberts, Andrea L.; Hart, Jaime E.; Weisskopf, Marc G.; Schwarzschild, Michael A.; Ascherio, Alberto; Laden, Francine (NLM-Export, 2014)Background: Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). Objectives: We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was ... -
Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications
Chen, Honglei; Burton, Edward A.; Ross, G. Webster; Huang, Xuemei; Savica, Rodolfo; Abbott, Robert D.; Ascherio, Alberto; Caviness, John N.; Gao, Xiang; Gray, Kimberly A.; Hong, Jau-Shyong; Kamel, Freya; Jennings, Danna; Kirshner, Annette; Lawler, Cindy; Liu, Rui; Miller, Gary W.; Nussbaum, Robert; Peddada, Shyamal D.; Rick, Amy Comstock; Ritz, Beate; Siderowf, Andrew D.; Tanner, Caroline M.; Tröster, Alexander I.; Zhang, Jing (National Institute of Environmental Health Sciences, 2013)Background: The etiology and natural history of Parkinson’s disease (PD) are not well understood. Some non-motor symptoms such as hyposmia, rapid eye movement sleep behavior disorder, and constipation may develop during ... -
Vitamin D and Neurodegenerative Disease With Selected Topics Related to Correlated and Missing Outcome Data
Fitzgerald, Kathryn C. (2015-09-15)The following dissertation addresses of two themes: the role of vitamin D and neurodegenerative diseases and methodologic concepts related to correlated missing outcome data. In the first chapter, the relation between ...