Now showing items 1-9 of 9

    • Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage 

      Fuchsluger, T A; Jurkunas, Ula V.; Kazlauskas, Andrius; Dana, Reza (Springer Nature, 2011)
      Corneal transplantation is the most common form of grafting performed worldwide. Corneal endothelial cells (EC) form a monolayer in the posterior portion of the cornea and are essential for corneal transparency. EC loss ...
    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose.: To investigate the ability of bevacizumab to penetrate the cornea after topical application or subconjunctival injection. Methods.: Bevacizumab 1% was topically applied three times a day to the corneas of mice ...
    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose. To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocal microscopy ...
    • Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease 

      Saboo, Ujwala S.; Amparo, Francisco; Shikari, Hasanain; Jurkunas, Ula V.; Dana, Reza (Springer Nature, 2015)
      Purpose To evaluate the outcomes of phacoemulsification in patients with ocular graft-versus-host disease (GVHD). Methods The occurrence of cataract, cataract surgery and its outcomes were analyzed in the medical ...
    • Safety and Efficacy of the Multitargeted Receptor Kinase Inhibitor Pazopanib in the Treatment of Corneal Neovascularization 

      Amparo, Francisco; Sadrai, Zahra; Jin, Yiping; Alfonso-Bartolozzi, Belen; Wang, Haobing; Shikari, Hasanain; Ciolino, Joseph B; Chodosh, James; Jurkunas, Ula V.; Schaumberg, Debra Ann; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. To evaluate the safety and efficacy of topical pazopanib in the treatment of corneal neovascularization (CNV). Methods. Twenty eyes of 20 patients with stable CNV were enrolled in a prospective, open ...
    • Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers 

      Schmedt, Thore; Chen, Yuming; Nguyen, Tracy T.; Li, Shimin; Bonanno, Joseph; Jurkunas, Ula V. (Public Library of Science, 2012)
      Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. HCEnCs are derived from neural crest and are arrested in the ...
    • Topical Bevacizumab in the Treatment of Corneal Neovascularization 

      Dastjerdi, Mohammad H.; Al-Arjaf, Khalid M.; Nallasamy, Nambi; Hamrah, Pedram; Jurkunas, Ula V.; Pineda, Roberto; Pavan-Langston, Deborah; Dana, Reza (American Medical Association (AMA), 2009)
      Objectives To study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV). Design In a prospective, open-label, non-comparative study, 10 eyes from 10 patients with ...
    • Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye Disease 

      Amparo, Francisco; Dastjerdi, Mohammad H.; Okanobo, Andre; Ferrari, Giulio; Smaga, Leila; Hamrah, Pedram; Jurkunas, Ula V.; Schaumberg, Debra Ann; Dana, Reza (American Medical Association (AMA), 2013)
      Importance The immunopathogenic mechanisms of dry eye disease (DED), one of the most common ophthalmic conditions, is incompletely understood. Data from this prospective, double-masked, randomized trial demonstrate that ...
    • UV-A Irradiation Activates Nrf2-Regulated Antioxidant Defense and Induces p53/Caspase3-Dependent Apoptosis in Corneal Endothelial Cells 

      Liu, Cailing; Vojnovic, Dijana; Kochevar, Irene E.; Jurkunas, Ula V. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose To examine whether Nrf2-regulated antioxidant defense and p53 are activated in human corneal endothelial cells (CEnCs) by environmental levels of ultraviolet A (UV-A), a known stimulator of oxidative stress. Methods: ...