Now showing items 1-20 of 63

    • Arthritis Imaging Using a Near-Infrared Fluorescence Folate-Targeted Probe 

      Chen, Wei-Tsung; Mahmood, Umar; Weissleder, Ralph; Tung, Ching-Hsuan (BioMed Central, 2005)
      A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum ...
    • Automated motion artifact removal for intravital microscopy, without a priori information 

      Lee, Sungon; Vinegoni, Claudio; Sebas, Matthew; Weissleder, Ralph (Nature Publishing Group, 2014)
      Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights ...
    • Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET 

      Kim, Eunha; Yang, Katherine S.; Weissleder, Ralph (Public Library of Science, 2013)
      The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical ...
    • Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers 

      Shao, Huilin (2013-10-15)
      Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ...
    • Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging 

      Vinegoni, Claudio; Razansky, Daniel; Figueiredo, Jose-Luiz; Fexon, Lyuba; Pivovarov, Misha; Nahrendorf, Matthias; Ntziachristos, Vasilis; Weissleder, Ralph (MyJove Corporation, 2009)
      Optical projection tomography is a three-dimensional imaging technique that has been recently introduced as an imaging tool primarily in developmental biology and gene expression studies. The technique renders biological ...
    • BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma 

      Jeong, Joseph H.; Wang, Zhenxiong; Ouyang, Xuesong; Jiang, Shan; Guney, Isil; Kang, Gyeong Hoon; Abate-Shen, Cory; Guimaraes, Alexander Savio Ramos; Figueiredo, Jose L.; Ding, Zhihu; Shin, Eyoung; Hahn, William C.; Loda, Massimo; Weissleder, Ralph; Chin, Lynda (Public Library of Science, 2008)
      Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic ...
    • Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis 

      Zeglis, Brian M; Emmetiere, Fabien; Pillarsetty, Nagavarakishore; Weissleder, Ralph; Lewis, Jason S; Reiner, Thomas (Wiley-VCH Verlag GmbH & Co, 2014)
      The need for post-synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents. In this regard, the application of biologically ...
    • Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma 

      Shao, Huilin; Chung, Jaehoon; Lee, Kyungheon; Balaj, Leonora; Min, Changwook; Carter, Bob S.; Hochberg, Fred H.; Breakefield, Xandra O.; Lee, Hakho; Weissleder, Ralph (Nature Pub. Group, 2015)
      Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6-methylguanine DNA methyltransferase) and ...
    • Chronic variable stress activates hematopoietic stem cells 

      Heidt, Timo; Sager, Hendrik B.; Courties, Gabriel; Dutta, Partha; Iwamoto, Yoshiko; Zaltsman, Alex; von zur Muhlen, Constantin; Bode, Christoph; Fricchione, Gregory L.; Denninger, John; Lin, Charles P.; Vinegoni, Claudio; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (2014)
      Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis1,2. While incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking ...
    • Companion Imaging Probes and Diagnostic Devices for B-Cell Lymphoma 

      Turetsky, Anna (2014-10-22)
      As new therapeutic targets and drugs are discovered for B-cell lymphoma and other cancers, companion diagnostics are also needed to determine target engagement, therapeutic efficacy, and patient segmentation for clinical ...
    • Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response 

      Giedt, Randy J.; Fumene Feruglio, Paolo; Pathania, Divya; Yang, Katherine S.; Kilcoyne, Aoife; Vinegoni, Claudio; Mitchison, Timothy J.; Weissleder, Ralph (Nature Publishing Group, 2016)
      Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on short-term molecular mechanisms underlying fission/fusion. Less is ...
    • Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction? 

      Nahrendorf, Matthias; Weissleder, Ralph; Ertl, Georg (Public Library of Science, 2006)
      Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests ...
    • Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging 

      Fu, Wenxian; Wojtkiewicz, Gregory; Weissleder, Ralph; Benoist, Christophe O.; Mathis, Diane J. (2012)
      All juvenile NOD mice exhibit insulitis, but there is substantial variation in their progression to diabetes. We demonstrate that a patient-validated magnetic-resonance-imaging (MRI) strategy to non-invasively visualize ...
    • Engineered Trehalose Permeable to Mammalian Cells 

      Abazari, Alireza; Meimetis, Labros G.; Budin, Ghyslain; Bale, Shyam Sundhar; Weissleder, Ralph; Toner, Mehmet (Public Library of Science, 2015)
      Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and ...
    • Enhancing Navigation in Biomedical Databases by Community Voting and Database-Driven Text Classification 

      Duchrow, Timo; Shtatland, Timur; Guettler, Daniel; Pivovarov, Misha; Kramer, Stefan; Weissleder, Ralph (BioMed Central, 2009)
      Background: The breadth of biological databases and their information content continues to increase exponentially. Unfortunately, our ability to query such sources is still often suboptimal. Here, we introduce and apply ...
    • Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells 

      Fu, Wenxian; Farache, Julia; Clardy, Susan M; Hattori, Kimie; Mander, Palwinder; Lee, Kevin; Rioja, Inmaculada; Weissleder, Ralph; Prinjha, Rab K; Benoist, Christophe; Mathis, Diane (eLife Sciences Publications, Ltd, 2014)
      Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment ...
    • Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications 

      Pathania, Divya; Im, Hyungsoon; Kilcoyne, Aoife; Sohani, Aliyah R.; Fexon, Lioubov; Pivovarov, Misha; Abramson, Jeremy S.; Randall, Thomas C.; Chabner, Bruce A.; Weissleder, Ralph; Lee, Hakho; Castro, Cesar M. (Ivyspring International Publisher, 2016)
      Low-cost, rapid and accurate detection technologies are key requisites to cope with the growing global cancer challenges. The need is particularly pronounced in resource-limited settings where treatment opportunities are ...
    • Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates 

      Giedt, Randy J.; Sprachman, Melissa M.; Yang, Katherine S.; Weissleder, Ralph (American Chemical Society, 2014)
      Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent ...
    • In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy 

      Chittajallu, Deepak R; Florian, Stefan; Kohler, Rainer H; Iwamoto, Yoshiko; Orth, James D; Weissleder, Ralph; Danuser, Gaudenz; Mitchison, Timothy J (2015)
      Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional biological processes such as tissue development and cancer. Analysis of 3D in vivo images, however, is very ...
    • In Vivo Tomographic Imaging of Red-Shifted Fluorescent Proteins 

      Deliolanis, Nikolaos C.; Wurdinger, Thomas; Pike, Lisa; Tannous, Bakhos A.; Breakefield, Xandra Owens; Weissleder, Ralph; Ntziachristos, Vasilis (Optical Society of America, 2011)
      We have developed a spectral inversion method for three-dimensional tomography of far-red and near-infrared fluorescent proteins in animals. The method was developed in particular to address the steep light absorption ...