Browsing by Author "Bhasin, Manoj"
Now showing items 1-15 of 15
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Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach
Skibsted, Simon; Bhasin, Manoj K; Aird, William C; Shapiro, Nathan I (BioMed Central, 2013)The early, accurate diagnosis and risk stratification of sepsis remains an important challenge in the critically ill. Since traditional biomarker strategies have not yielded a gold standard marker for sepsis, focus is ... -
Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contrast agent for targeted magnetic imaging of tumor cells
Singh, Gurpal; Arora, Vikas; Mewar, Sujeet; Sharma, Uma; Jagannathan, NR; Sapra, Sameer; Dinda, Amit K; Kharbanda, Surender; Singh, Harpal; Kumar, Manoj (Dove Medical Press, 2012)The purpose of the study was to develop tumor specific, water dispersible superparamagnetic iron oxide nanoparticles (SPIONs) and evaluate their efficacy as a contrast agent in magnetic resonance imaging (MRI). We have ... -
The effects of transfection reagent polyethyleneimine (PEI) and non-targeting control siRNAs on global gene expression in human aortic smooth muscle cells
Raof, Nurazhani A.; Rajamani, Deepa; Chu, Hsun-Chieh; Gurav, Aniket; Johnson, Joel M.; LoGerfo, Frank W.; Pradhan-Nabzdyk, Leena; Bhasin, Manoj (BioMed Central, 2016)Background: RNA interference (RNAi) is a powerful platform utilized to target transcription of specific genes and downregulate the protein product. To achieve effective silencing, RNAi is usually applied to cells or tissue ... -
Genomic and Clinical Effects Associated with a Relaxation Response Mind-Body Intervention in Patients with Irritable Bowel Syndrome and Inflammatory Bowel Disease
Kuo, Braden; Bhasin, Manoj; Jacquart, Jolene; Scult, Matthew A.; Slipp, Lauren; Riklin, Eric Isaac Kagan; Lepoutre, Veronique; Comosa, Nicole; Norton, Beth-Ann; Dassatti, Allison; Rosenblum, Jessica; Thurler, Andrea H.; Surjanhata, Brian C.; Hasheminejad, Nicole N.; Kagan, Leslee; Slawsby, Ellen; Rao, Sowmya R.; Macklin, Eric A.; Fricchione, Gregory L.; Benson, Herbert; Libermann, Towia A.; Korzenik, Joshua; Denninger, John W. (Public Library of Science, 2015)Introduction: Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) can profoundly affect quality of life and are influenced by stress and resiliency. The impact of mind-body interventions (MBIs) on IBS and ... -
Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice
Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ... -
Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma
Wang, Xiaoen; Solban, Nicolas; Khanna, Prateek; Callea, Marcella; Song, Jiaxi; Alsop, David C.; Pearsall, R. Scott; Atkins, Michael B.; Mier, James W.; Signoretti, Sabina; Alimzhanov, Marat; Kumar, Ravi; Bhasin, Manoj K.; Bhatt, Rupal S. (Impact Journals LLC, 2016)Treatment of metastatic renal cell carcinoma (mRCC) with agents that block signaling through vascular endothelial growth factor receptor 2 (VEGFR2) induces disease regression or stabilization in some patients; however, ... -
Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier
Bhasin, Manoj K.; Ndebele, Kenneth; Bucur, Octavian; Yee, Eric U.; Otu, Hasan H.; Plati, Jessica; Bullock, Andrea; Gu, Xuesong; Castan, Eduardo; Zhang, Peng; Najarian, Robert; Muraru, Maria S.; Miksad, Rebecca; Khosravi-Far, Roya; Libermann, Towia A. (Impact Journals LLC, 2016)Purpose Pancreatic ductal adenocarcinoma (PDAC) is largely incurable due to late diagnosis. Superior early detection biomarkers are critical to improving PDAC survival and risk stratification. Experimental Design Optimized ... -
Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer
Jedinak, Andrej; Curatolo, Adam; Zurakowski, David; Dillon, Simon; Bhasin, Manoj K; Libermann, Towia A; Roy, Roopali; Sachdev, Monisha; Loughlin, Kevin R; Moses, Marsha A (BioMed Central, 2015)Background: The objective of this study was to discover and to validate novel noninvasive biomarkers that distinguish between benign prostate hyperplasia (BPH) and localized prostate cancer (PCa), thereby helping to solve ... -
PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection
Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H.; Khankin, Eliyahu V.; Bhasin, Manoj K.; Kim, Wondong; Clish, Clary B.; Stillman, Isaac E.; Karumanchi, S. Ananth; Rhee, Eugene P.; Parikh, Samir M. (2016)The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized ... -
Preliminary Biomarkers for Identification of Human Ascending Thoracic Aortic Aneurysm
Black, Kendra M.; Masuzawa, Akihiro; Hagberg, Robert C.; Khabbaz, Kamal R.; Trovato, Mary E.; Rettagliati, Verna M.; Bhasin, Manoj K.; Dillon, Simon T.; Libermann, Towia A.; Toumpoulis, Ioannis K.; Levitsky, Sidney; McCully, James D. (Blackwell Publishing Ltd, 2013)Background: Human ascending thoracic aortic aneurysms (ATAAs) are life threatening and constitute a leading cause of mortality in the United States. Previously, we demonstrated that collagens α2(V) and α1(XI) mRNA and ... -
Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity
Dillon, Simon T; Bhasin, Manoj K; Feng, Xiaoxing; Koh, David W; Daoud, Sayed S (BioMed Central, 2013)Background: The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity ... -
Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways
Bhasin, Manoj; Dusek, Jeffery A.; Chang, Bei-Hung; Joseph, Marie G.; Denninger, John Weber; Fricchione, Gregory Lewis; Benson, Herbert; Libermann, Towia Aron (Public Library of Science, 2013)The relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention ... -
SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1
de Vasconcellos, Jaíra Ferreira; Laranjeira, Angelo Brunelli Albertoni; Leal, Paulo C.; Bhasin, Manoj K.; Zenatti, Priscila Pini; Nunes, Ricardo J.; Yunes, Rosendo A.; Nowill, Alexandre E.; Libermann, Towia A.; Zerbini, Luiz Fernando; Yunes, José Andrés (Public Library of Science, 2015)Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea). ... -
Temporal retinal transcriptome and systems biology analysis identifies key pathways and hub genes in Staphylococcus aureus endophthalmitis
Rajamani, Deepa; Singh, Pawan Kumar; Rottmann, Bruce G.; Singh, Natasha; Bhasin, Manoj K.; Kumar, Ashok (Nature Publishing Group, 2016)Bacterial endophthalmitis remains a devastating inflammatory condition associated with permanent vision loss. Hence, assessing the host response in this disease may provide new targets for intervention. Using a mouse model ... -
Transcriptional Patterns in Peritoneal Tissue of Encapsulating Peritoneal Sclerosis, a Complication of Chronic Peritoneal Dialysis
Reimold, Fabian Raoul; Braun, Niko; Zsengellér, Zsuzsanna K.; Stillman, Isaac Ely; Karumanchi, Subbian Ananth; Toka, Hakan; Latus, Joerg; Fritz, Peter; Biegger, Dagmar; Segerer, Stephan; Alscher, M. Dominik; Bhasin, Manoj; Alper, Seth Leo (Public Library of Science, 2013)Encapsulating peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis (PD), characterized by marked inflammation and severe fibrosis of the peritoneum, and associated with high morbidity and mortality. ...