Now showing items 1-18 of 18

    • Analysis of the African coelacanth genome sheds light on tetrapod evolution 

      Amemiya, Chris T.; Alföldi, Jessica; Lee, Alison P.; Fan, Shaohua; Philippe, Hervé; MacCallum, Iain; Braasch, Ingo; Manousaki, Tereza; Schneider, Igor; Rohner, Nicolas; Organ, Chris; Chalopin, Domitille; Smith, Jeramiah J.; Robinson, Mark; Dorrington, Rosemary A.; Gerdol, Marco; Aken, Bronwen; Biscotti, Maria Assunta; Barucca, Marco; Baurain, Denis; Berlin, Aaron M.; Blatch, Gregory L.; Buonocore, Francesco; Burmester, Thorsten; Campbell, Michael S.; Canapa, Adriana; Cannon, John P.; Christoffels, Alan; De Moro, Gianluca; Edkins, Adrienne L.; Fan, Lin; Fausto, Anna Maria; Feiner, Nathalie; Forconi, Mariko; Gamieldien, Junaid; Gnerre, Sante; Gnirke, Andreas; Goldstone, Jared V.; Haerty, Wilfried; Hahn, Mark E.; Hesse, Uljana; Hoffmann, Steve; Johnson, Jeremy; Karchner, Sibel I.; Kuraku, Shigehiro; Lara, Marcia; Levin, Joshua Z.; Litman, Gary W.; Mauceli, Evan; Miyake, Tsutomu; Mueller, M. Gail; Nelson, David R.; Nitsche, Anne; Olmo, Ettore; Ota, Tatsuya; Pallavicini, Alberto; Panji, Sumir; Picone, Barbara; Ponting, Chris P.; Prohaska, Sonja J.; Przybylski, Dariusz; Saha, Nil Ratan; Ravi, Vydianathan; Ribeiro, Filipe J.; Sauka-Spengler, Tatjana; Scapigliati, Giuseppe; Searle, Stephen M. J.; Sharpe, Ted; Simakov, Oleg; Stadler, Peter F.; Stegeman, John J.; Sumiyama, Kenta; Tabbaa, Diana; Tafer, Hakim; Turner-Maier, Jason; van Heusden, Peter; White, Simon; Williams, Louise; Yandell, Mark; Brinkmann, Henner; Volff, Jean-Nicolas; Tabin, Clifford J.; Shubin, Neil; Schartl, Manfred; Jaffe, David; Postlethwait, John H.; Venkatesh, Byrappa; Di Palma, Federica; Lander, Eric S.; Meyer, Axel; Lindblad-Toh, Kerstin (2013)
      It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks ...
    • Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle 

      Tzahor, Eldad; Kempf, Hervé; Mootoosamy, Roy C.; Poon, Andy C.; Abzhanov, Arkhat; Tabin, Clifford James; Dietrich, Susanne; Lassar, Andrew B. (Cold Spring Harbor Laboratory Press, 2003)
      Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk ...
    • Diverse Roles of Cell Signaling during Early and Late Phases of Limb Development 

      Hu, Jimmy Kuang-Hsien (2013-02-06)
      The development of the vertebrate limb is a progressive process characterized by initial induction and patterning, concomitant growth and morphogenesis, and subsequent cell differentiation and tissue formation. Many of ...
    • Evolution of Morphology: Modifications to Size and Pattern 

      Uygur, Aysu N (2014-06-06)
      A remarkable property of developing organisms is the consistency and robustness within the formation of the body plan. In many animals, morphological pattern formation is orchestrated by conserved signaling pathways, through ...
    • Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis 

      Bandyopadhyay, Amitabha; Tsuji, Kunikazu; Cox, Karen Ann; Harfe, Brian D; Rosen, Vicki; Tabin, Clifford James (Public Library of Science, 2006)
      Bone morphogenetic protein (BMP) family members, including BMP2, BMP4, and BMP7, are expressed throughout limb development. BMPs have been implicated in early limb patterning as well as in the process of skeletogenesis. ...
    • The genetic basis of behavior in the blind Mexican cavefish, Astyanax mexicanus 

      Kowalko, Johanna Elizabeth (2013-10-18)
      In recent years, considerable progress has been made towards understanding the genetic basis of the evolution of morphological traits. In contrast, relatively little is known about how behavioral traits evolve. Astyanax ...
    • A genetic basis of variation in eccrine sweat gland and hair follicle density 

      Kamberov, Yana George; Karlsson, Elinor; Kamberova, Gerda L.; Lieberman, Daniel E.; Sabeti, Pardis Christine; Morgan, Bruce Allan; Tabin, Clifford James (Proceedings of the National Academy of Sciences, 2015)
      Among the unique features of humans, one of the most salient is the ability to effectively cool the body during extreme prolonged activity through the evapotranspiration of water on the skin's surface. The evolution of ...
    • Limb regeneration revisited 

      Whited, Jessica LaMae; Tabin, Clifford James (BioMed Central, 2009)
      The investigation of vertebrate limb regeneration, a favorite topic of early developmental biologists, is enjoying a renaissance thanks to recently developed molecular and genetic tools, as indicated in recent papers in ...
    • Loss of Schooling Behavior in Cavefish through Sight-Dependent and Sight-Independent Mechanisms 

      Kowalko, Johanna Elizabeth; Rohner, Nicolas; Rompani, Santiago B.; Peterson, Brant K.; Linden, Tess Augusta; Yoshizawa, Masato; Kay, Emily H.; Weber, Jesse; Hoekstra, Hopi E.; Jeffery, William R.; Borowsky, Richard; Tabin, Clifford James (Elsevier BV, 2013)
      Background: Surface populations of Astyanax mexicanus, living in rivers like their common ancestors, school, while several, independently derived cave populations of the same species have lost schooling behavior.Results: ...
    • Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant 

      Kamberov, Yana George; Wang, Sijia; Tan, Jingze; Gerbault, Pascale; Wark, Abigail; Tan, Longzhi; Yang, Yajun; Li, Shilin; Tang, Kun; Chen, Hua; Powell, Adam; Itan, Yuval; Fuller, Dorian; Lohmueller, Jason; Mao, Junhao; Schachar, Asa; Paymer, Madeline; Hostetter, Elizabeth; Byrne, Elizabeth; Burnett, Melissa; McMahon, Andrew P.; Thomas, Mark G.; Lieberman, Daniel E.; Jin, Li; Tabin, Clifford James; Morgan, Bruce Allan; Sabeti, Pardis Christine (Elsevier BV, 2013)
      An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype ...
    • Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions 

      Cooper, Kimberly L.; Oh, Seungeun; Sung, Yongjin; Dasari, Ramachandra R.; Kirschner, Marc W.; Tabin, Clifford J. (2013)
      Even a casual pass through the great halls of mammals in the world’s natural history museums highlights the wide diversity of skeletal proportions that allow us to distinguish between species even when reduced to their ...
    • Multiple Phylogenetically Distinct Events Shaped the Evolution of Limb Skeletal Morphologies Associated with Bipedalism in the Jerboas 

      Moore, Talia Yuki; Organ, Chris; Edwards, Scott V.; Biewener, Andrew Austin; Tabin, Clifford James; Farish, Jenkins; Cooper, Kimberly (Elsevier BV, 2015)
      Recent rapid advances in experimental biology have expanded the opportunity for interdisciplinary investigations of the evolution of form and function in non-traditional model species. However, historical divisions of ...
    • A Novel Role for Mc1r in the Parallel Evolution of Depigmentation in Independent Populations of the Cavefish Astyanax mexicanus 

      Gross, Joshua B.; Borowsky, Richard; Tabin, Clifford James (Public Library of Science, 2009)
      The evolution of degenerate characteristics remains a poorly understood phenomenon. Only recently has the identification of mutations underlying regressive phenotypes become accessible through the use of genetic analyses. ...
    • Regeneration Review Reprise 

      Whited, Jessica LaMae; Tabin, Clifford James (BioMed Central, 2010)
      There have been notable advances in the scientific understanding of regeneration within the past year alone, including two recently published in BMC Biology. Increasingly, progress in the regeneration field is being inspired ...
    • Regulation of skeletogenic differentiation in cranial dermal bone 

      Abzhanov, Arkhat; Rodda, S. J.; McMahon, A. P.; Tabin, Clifford James (The Company of Biologists, 2007)
      Although endochondral ossification of the limb and axial skeleton is relatively well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skeletal elements is not nearly as well-characterized. ...
    • A relative shift in cloacal location repositions external genitalia in amniote evolution 

      Tschopp, Patrick; Sherratt, Emma; Sanger, Thomas J.; Groner, Anna C.; Aspiras, Ariel C.; Hu, Jimmy K.; Pourquié, Olivier; Gros, Jérôme; Tabin, Clifford J. (2014)
      The move of vertebrates to a terrestrial lifestyle required major adaptations in their locomotory apparatus and reproductive organs. While the fin-to-limb transition has received considerable attention1,2, little is known ...
    • The Role of Mechanical Forces in Patterning and Morphogenesis of the Vertebrate Gut 

      Shyer, Amy Elizabeth (2013-09-30)
      The vertebrate small intestine is responsible for nutrient absorption during digestion. To this end, the surface area of the gut tube is maximally expanded, both through a series of loops extending its length and via the ...
    • Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube 

      Uygur, Aysu; Young, John; Huycke, Tyler R.; Koska, Mervenaz; Briscoe, James; Tabin, Clifford J. (2016)
      SUMMARY Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly ...