Now showing items 1-13 of 13

    • Aging, brain disease, and reserve: Implications for delirium 

      Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction? 

      Fong, Tamara G; Inouye, Sharon; Dai, Weiying; Press, Daniel; Alsop, David C. (Springer Science + Business Media, 2010)
      Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls ...
    • Calibration and Validation of an Innovative Approach for Estimating General Cognitive Performance 

      Gross, Alden L.; Jones, Richard Norman; Fong, Tamara G; Tommet, Douglas; Inouye, Sharon (S. Karger AG, 2014)
      Objective: To evaluate a new approach for creating a composite measure of cognitive function, we calibrated a measure of general cognitive performance from existing neuropsychological batteries. Methods: We applied our ...
    • Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence 

      Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)
      Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ...
    • Cognitive and Physical Demands of Activities of Daily Living In Older Adults: Validation of Expert Panel Ratings: The SAGES Functional Measures Working Group 

      Fong, Tamara G.; Gleason, Lauren J.; Wong, Bonnie; Habtemariam, Daniel; Jones, Richard N.; Schmitt, Eva M.; de Rooij, Sophia E.; Saczynski, Jane S.; Gross, Alden L.; Bean, Jonathan F.; Brown, Cynthia J.; Fick, Donna M.; Gruber-Baldini, Ann L.; O’Connor, Margaret; Tabloski, Patrica A.; Marcantonio, Edward R.; Inouye, Sharon K. (2015)
      Background: Difficulties with performance of functional activities may result from cognitive and/or physical impairments. To date, there has not been a clear delineation of the physical and cognitive demands of activities ...
    • Cognitive Trajectories after Postoperative Delirium 

      Saczynski, Jane S.; Marcantonio, Edward Ralph; Quach, Lien; Fong, Tamara G; Gross, Alden; Inouye, Sharon; Jones, Richard Norman (New England Journal of Medicine (NEJM/MMS), 2012)
      Background Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac ...
    • Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia 

      Vasunilashorn, Sarinnapha; Fong, Tamara G; Albuquerque, Asha; Marcantonio, Edward Ralph; Schmitt, Eva M.; Tommet, Douglas; Gou, Yun; Travison, Thomas G; Jones, Richard N.; Inouye, Sharon K. (IOS Press, 2017)
      Background: Delirium has been associated with more rapid cognitive decline. However, it is unknown whether increased delirium severity is associated with a higher rate of long-term cognitive decline. Objective: To evaluate ...
    • Delirium: An Independent Predictor of Functional Decline After Cardiac Surgery 

      Rudolph, James; Inouye, Sharon; Jones, Richard N.; Yang, Frances Margaret; Fong, Tamara G; Levkoff, Sue E.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2010)
      OBJECTIVES: To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline. DESIGN: Prospective cohort study. SETTING: Two academic hospitals and a Veterans Affairs ...
    • Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision 

      Jones, Richard Norman; Rudolph, James; Inouye, Sharon; Yang, Frances Margaret; Fong, Tamara G; Milberg, William Paul; Tommet, Douglas; Metzger, Eran Daniel; Cupples, L. Adrienne; Marcantonio, Edward Ralph (Informa UK Limited, 2010)
      The objective of this analysis was to develop a measure of neuropsychological performance for cardiac surgery and to assess its psychometric properties. Older patients (n = 210) underwent a neuropsychological battery using ...
    • Identifying Indicators of Important Diagnostic Features of Delirium 

      Huang, Li-Wen; Inouye, Sharon; Jones, Richard Norman; Fong, Tamara G; Rudolph, James; O, Margaret G.; Metzger, Eran Daniel; Crane, Paul K.; Marcantonio, Edward Ralph (Wiley-Blackwell, 2012)
      OBJECTIVES: To use an expert consensus process to identify indicators of delirium features to help enhance bedside recognition of delirium. DESIGN: Modified Delphi consensus process to assign existing cognitive and ...
    • Maximizing Clinical Research Participation in Vulnerable Older Persons: Identification of Barriers and Motivators 

      Marcantonio, Edward Ralph; Aneja, Jasneet; Jones, Richard Norman; Alsop, David C.; Fong, Tamara G; Crosby, Gregory; Culley, Deborah Jean; Cupples, L. Adrienne; Inouye, Sharon (Wiley-Blackwell, 2008)
      OBJECTIVES: To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention. DESIGN: Quantitative and ...
    • Novel Risk Markers and Long-Term Outcomes of Delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods 

      Schmitt, Eva M.; Marcantonio, Edward Ralph; Alsop, David C.; Jones, Richard Norman; Rogers, Selwyn O.; Fong, Tamara G; Metzger, Eran Daniel; Inouye, Sharon (Elsevier BV, 2012)
      Objectives: Delirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been ...
    • Telephone Interview for Cognitive Status: Creating a crosswalk with the Mini-Mental State Examination 

      Fong, Tamara G; Fearing, Michael A.; Jones, Richard Norman; Shi, Peilin; Marcantonio, Edward Ralph; Rudolph, James; Yang, Frances Margaret; Kiely, Dan K.; Inouye, Sharon (Elsevier BV, 2009)
      Background Brief cognitive screening measures are valuable tools for both research and clinical applications. The most widely used instrument, the Mini-Mental State Examination (MMSE), is limited in that it must be ...