Now showing items 1-4 of 4

    • The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis 

      Carrasco, Daniel R.; Sukhdeo, Kumar; Protopopova, Marina; Enos, Miriam; Zheng, Mei; Mani, Mala; Ivanova, Elena V.; Tonon, Giovanni; Sinha, Raktim; Carrasco, Daniel E.; Henderson, Joel Michael; Pinkus, Geraldine Sowinski; Munshi, Nikhil C; Horner, James W.; Protopopov, Alexei; Anderson, Kenneth Carl; DePinho, Ronald A. (Cell Press, 2007)
      Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with ...
    • Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry 

      Kluk, Michael J.; Ashworth, Todd; Wang, Hongfang; Knoechel, Birgit; Mason, Emily F.; Morgan, Elizabeth A.; Dorfman, David; Pinkus, Geraldine; Weigert, Oliver; Hornick, Jason L.; Chirieac, Lucian R.; Hirsch, Michelle; Oh, David J.; South, Andrew P.; Leigh, Irene M.; Pourreyron, Celine; Cassidy, Andrew J.; DeAngelo, Daniel J.; Weinstock, David M.; Krop, Ian E.; Dillon, Deborah; Brock, Jane E.; Lazar, Alexander J. F.; Peto, Myron; Cho, Raymond J.; Stoeck, Alexander; Haines, Brian B.; Sathayanrayanan, Sriram; Rodig, Scott; Aster, Jon C. (Public Library of Science, 2013)
      Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been ...
    • Immunohistochemical Markers Associated With Brain Metastases in Patients with Nonsmall Cell Lung Carcinoma 

      Saad, Ali G.; Yeap, Beow; Thunnissen, Frederik B. J. M.; Pinkus, Geraldine; Pinkus, Jack; Loda, Massimo; Sugarbaker, David J.; Johnson, Bruce; Chirieac, Lucian (Wiley, 2008-10-15)
      BACKGROUND There are no reliable markers able to identify patients with non-small cell lung cancer (NSCLC) likely to metastasize to the brain. We investigated associations between immunohistochemical markers and development ...
    • Relevant Mouse Model for Human Monocytic Leukemia through Cre/lox-Controlled Myeloid-Specific Deletion of PTEN 

      Yu, H.; Li, Yili; Gao, Chuanyun; Fabien, L.; Jia, Y.; Lu, Junjie; Silberstein, Leslie E.; Pinkus, Geraldine Sowinski; Ye, K.; Chai, Li; Luo, Hongbo (Nature Publishing Group, 2010)