Now showing items 1-8 of 8

    • Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia 

      Konstantopoulos, Christina; Ribaudo, Heather; Ragland, Kathleen; Bangsberg, David R.; Li, Jonathan Z. (Oxford University Press, 2015)
      Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy ...
    • Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials 

      Treasure, Graham C.; Aga, Evgenia; Bosch, Ronald J.; Mellors, John W.; Kuritzkes, Daniel R.; Para, Michael; Gandhi, Rajesh T.; Li, Jonathan Z. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016)
      Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between ...
    • Characteristics and Outcomes of Initial Virologic Suppressors during Analytic Treatment Interruption in a Therapeutic HIV-1 \(gag\) Vaccine Trial 

      Brumme, Chanson J.; Lederman, Michael M.; Brumme, Zabrina L.; Wang, Hongying; Carrington, Mary; Medvik, Kathleen; Schooley, Robert T.; Li, Jonathan Zheng; Spritzle, John; Walker, Bruce David; Kuritzkes, Daniel Robert (Public Library of Science, 2012)
      Background: In the placebo-controlled trial ACTG A5197, a trend favoring viral suppression was seen in the HIV-1-infected subjects who received a recombinant Ad5 HIV-1 \(gag\) vaccine. Objective: To identify individuals ...
    • Comparison of Illumina and 454 Deep Sequencing in Participants Failing Raltegravir-Based Antiretroviral Therapy 

      Li, Jonathan Z.; Chapman, Brad; Charlebois, Patrick; Hofmann, Oliver; Weiner, Brian; Porter, Alyssa J.; Samuel, Reshmi; Vardhanabhuti, Saran; Zheng, Lu; Eron, Joseph; Taiwo, Babafemi; Zody, Michael C.; Henn, Matthew R.; Kuritzkes, Daniel R.; Hide, Winston; Wilson, Cara C.; Berzins, Baiba I.; Acosta, Edward P.; Bastow, Barbara; Kim, Peter S.; Read, Sarah W.; Janik, Jennifer; Meres, Debra S.; Lederman, Michael M.; Mong-Kryspin, Lori; Shaw, Karl E.; Zimmerman, Louis G.; Leavitt, Randi; De La Rosa, Guy; Jennings, Amy (Public Library of Science, 2014)
      Background: The impact of raltegravir-resistant HIV-1 minority variants (MVs) on raltegravir treatment failure is unknown. Illumina sequencing offers greater throughput than 454, but sequence analysis tools for viral ...
    • Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies 

      Tang, Jonathan CY; Drokhlyansky, Eugene; Etemad, Behzad; Rudolph, Stephanie; Guo, Binggege; Wang, Sui; Ellis, Emily G; Li, Jonathan Z; Cepko, Constance L (eLife Sciences Publications, Ltd, 2016)
      The ability to detect and/or manipulate specific cell populations based upon the presence of intracellular protein epitopes would enable many types of studies and applications. Protein binders such as nanobodies (Nbs) can ...
    • Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics 

      Li, Jonathan Z.; Arnold, Kelly B.; Lo, Janet; Dugast, Anne-Sophie; Plants, Jill; Ribaudo, Heather J.; Cesa, Kevin; Heisey, Andrea; Kuritzkes, Daniel R.; Lauffenburger, Douglas A.; Alter, Galit; Landay, Alan; Grinspoon, Steven; Pereyra, Florencia (Oxford University Press, 2014)
      Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. ...
    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...
    • Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents 

      Delagrèverie, Héloïse M.; Delaugerre, Constance; Lewin, Sharon R.; Deeks, Steven G.; Li, Jonathan Z. (Oxford University Press, 2016)
      In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or ...