Now showing items 1-5 of 5

    • Directed Differentiation of Pluripotent Stem Cells into Kidney 

      Morizane, Ryuji; Lam, Albert Q (Libertas Academica, 2015)
      Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), represent an ideal substrate for regenerating kidney cells and tissue lost through injury and disease. Recent ...
    • Generation of kidney tubular organoids from human pluripotent stem cells 

      Yamaguchi, Shintaro; Morizane, Ryuji; Homma, Koichiro; Monkawa, Toshiaki; Suzuki, Sayuri; Fujii, Shizuka; Koda, Muneaki; Hiratsuka, Ken; Yamashita, Maho; Yoshida, Tadashi; Wakino, Shu; Hayashi, Koichi; Sasaki, Junichi; Hori, Shingo; Itoh, Hiroshi (Nature Publishing Group, 2016)
      Recent advances in stem cell research have resulted in methods to generate kidney organoids from human pluripotent stem cells (hPSCs), which contain cells of multiple lineages including nephron epithelial cells. Methods ...
    • Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury 

      Kishi, Seiji; Campanholle, Gabriela; Gohil, Vishal M.; Perocchi, Fabiana; Brooks, Craig R.; Morizane, Ryuji; Sabbisetti, Venkata; Ichimura, Takaharu; Mootha, Vamsi K.; Bonventre, Joseph V. (Elsevier, 2015)
      Global or local ischemia contributes to the pathogenesis of acute kidney injury (AKI). Currently there are no specific therapies to prevent AKI. Potentiation of glycolytic metabolism and attenuation of mitochondrial ...
    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids 

      Freedman, Benjamin S.; Brooks, Craig R.; Lam, Albert Q.; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; Saad, Abdelaziz F.; Li, Michelle K.; Hughes, Michael R.; Werff, Ryan Vander; Peters, Derek T.; Lu, Junjie; Baccei, Anna; Siedlecki, Andrew M.; Valerius, M. Todd; Musunuru, Kiran; McNagny, Kelly M.; Steinman, Theodore I.; Zhou, Jing; Lerou, Paul H.; Bonventre, Joseph V. (Nature Pub. Group, 2015)
      Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we ...
    • Nephron organoids derived from human pluripotent stem cells model kidney development and injury 

      Morizane, Ryuji; Lam, Albert Q.; Freedman, Benjamin S.; Kishi, Seiji; Valerius, M. Todd; Bonventre, Joseph V. (2015)
      Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) would enable organ regeneration, disease modeling, and drug screening in vitro. We established an efficient, chemically defined protocol for ...