Browsing by Author "Konstantinopoulos, Panagiotis"
Now showing items 1-13 of 13
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Analysis of Multiple Sarcoma Expression Datasets: Implications for Classification, Oncogenic Pathway Activation and Chemotherapy Resistance
Konstantinopoulos, Panagiotis; Fountzilas, Elena; Goldsmith, Jeffrey David; Bhasin, Manoj; Pillay, Kamana; Francoeur, Nancy; Libermann, Towia Aron; Gebhardt, Mark Clyde; Spentzos, Dimitrios (Public Library of Science, 2010)Background: Diagnosis of soft tissue sarcomas (STS) is challenging. Many remain unclassified (not-otherwise-specified, NOS) or grouped in controversial categories such as malignant fibrous histiocytoma (MFH), with unclear ... -
Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer
Strickland, Kyle C.; Howitt, Brooke E.; Shukla, Sachet A.; Rodig, Scott; Ritterhouse, Lauren L.; Liu, Joyce F.; Garber, Judy E.; Chowdhury, Dipanjan; Wu, Catherine J.; D'Andrea, Alan D.; Matulonis, Ursula A.; Konstantinopoulos, Panagiotis A. (Impact Journals LLC, 2016)Immune checkpoint inhibitors (e.g., anti-PD-1 and anti-PD-L1 antibodies) have demonstrated remarkable efficacy against hypermutated cancers such as melanomas and lung carcinomas. One explanation for this effect is that ... -
Association of Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1
Howitt, Brooke Elizabeth; Shukla, Sachet; Sholl, Lynette Marie; Ritterhouse, Lauren Lee; Watkins, Jaclyn Christine; Rodig, Scott J.; Stover, Elizabeth Harmon; Strickland, Kyle Craig; D'Andrea, Alan David; Wu, Catherine Ju-Ying; Matulonis, Ursula Anne; Konstantinopoulos, Panagiotis (American Medical Association (AMA), 2015)Importance Immune checkpoint inhibitor therapy has shown benefit in various cancers, but their potential in endometrial cancer (EC) is unknown. Observations Prediction of neoantigen load was performed using sequencing ... -
Carboplatin-Induced Gene Expression Changes In Vitro are Prognostic of Survival in Epithelial Ovarian Cancer
Konstantinopoulos, Panagiotis; Fountzilas, Elena; Pillay, Kamana; Zerbini, Luiz F; Libermann, Towia Aron; Cannistra, Stephen Anthony; Spentzos, Dimitrios (BioMed Central, 2008)Background: We performed a time-course microarray experiment to define the transcriptional response to carboplatin in vitro, and to correlate this with clinical outcome in epithelial ovarian cancer (EOC). RNA was isolated ... -
Current Status and Evolution of Preclinical Drug Development Models of Epithelial Ovarian Cancer
Konstantinopoulos, Panagiotis A.; Matulonis, Ursula A. (Frontiers Media S.A., 2013)Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and the fifth most common cause of female cancer death in the United States. Although important advances in surgical and chemotherapeutic strategies ... -
EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF
Konstantinopoulos, Panagiotis A.; Vandoros, Gerasimos P.; Karamouzis, Michalis V.; Gkermpesi, Maria; Sotiropoulou-Bonikou, Georgia; Papavassiliou, Athanasios G. (IOS Press, 2007)Background:: COX-2 and VEGF are important triggers of colon cancer growth, metastasis and angiogenesis. Cox-2 promoter contains transcriptional regulatory elements for AP-1 and NF-κ:B transcription factors whilst vegf is ... -
Integrated Analysis of Multiple Microarray Datasets Identifies a Reproducible Survival Predictor in Ovarian Cancer
Konstantinopoulos, Panagiotis; Cannistra, Stephen Anthony; Fountzilas, Helen; Culhane, Aedin; Pillay, Kamana; Rueda, Bo Ruben; Cramer, Daniel William; Seiden, Michael; Birrer, Michael James; Coukos, George; Zhang, Lin; Quackenbush, John; Spentzos, Dimitrios (Public Library of Science (PLoS), 2011)Background Public data integration may help overcome challenges in clinical implementation of microarray profiles. We integrated several ovarian cancer datasets to identify a reproducible predictor of survival. Met ... -
A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study
Fountzilas, Elena; Kelly, Andrew D; Perez-Atayde, Antonio Rafael; Goldsmith, Jeffrey David; Konstantinopoulos, Panagiotis; Francoeur, Nancy; Correll, Mick; Rubio, Renee; Hu, Lan; Gebhardt, Mark Clyde; Quackenbush, John; Spentzos, Dimitrios (BioMed Central, 2012)Background: MicroRNAs (miRNAs) are nucleic acid regulators of many human mRNAs, and are associated with many tumorigenic processes. miRNA expression levels have been used in profiling studies, but some evidence suggests ... -
MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability
Choi, Young Eun; Pan, Yunfeng; Park, Eunmi; Konstantinopoulos, Panagiotis; De, Subhajyoti; D'Andrea, Alan; Chowdhury, Dipanjan (eLife Sciences Publications, Ltd, 2014)Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) ... -
Morphologic and Immunophenotypic Evidence of In-Situ Kaposi's Sarcoma
Konstantinopoulos, Panagiotis; Dezube, Bruce J; Pantanowitz, Liron (BioMed Central, 2006)Background: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. Case Presentation: We report, for the first time, a case providing direct histological evidence of the development of early ... -
Predicted neoantigen load in non-hypermutated endometrial cancers: Correlation with outcome and tumor-specific genomic alterations
Shukla, Sachet A.; Howitt, Brooke E.; Wu, Catherine J.; Konstantinopoulos, Panagiotis A. (Elsevier, 2017)Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have ... -
Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells
Chaudhuri, Arnab Ray; Callen, Elsa; Ding, Xia; Gogola, Ewa; Duarte, Alexandra A.; Lee, Ji-Eun; Wong, Nancy; Lafarga, Vanessa; Calvo, Jennifer A.; Panzarino, Nicholas J.; John, Sam; Day, Amanda; Crespo, Anna Vidal; Shen, Binghui; Starnes, Linda M.; de Ruiter, Julian R.; Daniel, Jeremy A.; Konstantinopoulos, Panagiotis A.; Cortez, David; Cantor, Sharon B.; Fernandez-Capetillo, Oscar; Ge, Kai; Jonkers, Jos; Rottenberg, Sven; Sharan, Shyam K.; Nussenzweig, André (2016)Brca1- and Brca2-deficient cells have reduced capacity to repair DNA double-strand breaks (DSBs) by homologous recombination (HR) and consequently are hypersensitive to DNA damaging agents, including cisplatin and ... -
Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells
Choi, Young Eun; Battelli, Chiara; Watson, Jacqueline; Liu, Joyce; Curtis, Jennifer; Morse, Alexander N.; Matulonis, Ursula A.; Chowdhury, Dipanjan; Konstantinopoulos, Panagiotis A. (Impact Journals LLC, 2014)The promise of PARP-inhibitors(PARPis) in the management of epithelial ovarian cancer(EOC) is tempered by the fact that approximately 50% of patients with homologous recombination (HR)-proficient tumors do not respond well ...