Now showing items 1-3 of 3

    • The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation 

      Tremblay, Annie M.; Missiaglia, Edoardo; Galli, Giorgio G.; Hettmer, Simone; Urcia, Roby; Carrara, Matteo; Judson, Rebekah M; Thway, Khin; Nadal, Gema; Selfe, Joanna L.; Murray, Graeme; Calogero, Raffaele A.; De Bari, Cosimo; Zammit, Peter S.; Delorenzi, Mauro; Wagers, Amy Jo; Shipley, Janet; Wackerhage, Henning; Camargo, Fernando D. (Elsevier BV, 2014)
      The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in ...
    • Restriction of intestinal stem cell expansion and the regenerative response by YAP 

      Barry, Evan R.; Morikawa, Teppei; Butler, Brian L.; Shrestha, Kriti; de la Rosa, Rosemarie; Yan, Kelley S.; Fuchs, Charles S.; Magness, Scott T.; Smits, Ron; Ogino, Shuji; Kuo, Calvin J.; Camargo, Fernando D. (2012)
      A remarkable feature of regenerative processes is their ability to halt proliferation once an organ’s structure has been restored. The Wnt signaling pathway is the major driving force for homeostatic self-renewal and ...
    • Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth 

      Cox, Andrew G.; Hwang, Katie L.; Brown, Kristin K.; Evason, Kimberley; Beltz, Sebastian; Tsomides, Allison; O'Connor, Keelin; Galli, Giorgio G.; Yimlamai, Dean; Chhangawala, Sagar; Yuan, Min; Lien, Evan C.; Wucherpfennig, Julia; Nissim, Sahar; Minami, Akihiro; Cohen, David E.; Camargo, Fernando D.; Asara, John M.; Houvras, Yariv; Stainier, Didier Y.R.; Goessling, Wolfram (2016)
      The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic ...