Now showing items 1-20 of 28

    • Abnormal Angular Gyrus Asymmetry in Schizophrenia 

      Niznikiewicz, Margaret A.; Donnino, Robert; McCarley, Robert William; Nestor, Paul Gerard; Iosifescu, Daniel V.; O'Donnell, Brian; Levitt, James Jonathan; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2000)
      Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language—all functions that have been reported to be abnormal in schizophrenia. ...
    • Altered orbitofrontal sulcogyral pattern in schizophrenia 

      Nakamura, M.; Nestor, Paul Gerard; McCarley, Robert William; Levitt, James Jonathan; Hsu, Liangge; Kawashima, T.; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth (Oxford University Press (OUP), 2007)
      Orbitofrontal alteration in schizophrenia has not been well characterized, likely due to marked anatomical variability. To investigate the presence of such alterations, we evaluated the sulcogyral pattern of this ‘H-shaped’ ...
    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...
    • Attentional Control and Intelligence: MRI Orbital Frontal Gray Matter and Neuropsychological Correlates 

      Nestor, Paul G.; Nakamura, Motoaki; Niznikiewicz, Margaret; Levitt, James J.; Newell, Dominick T.; Shenton, Martha E.; McCarley, Robert W. (Hindawi Publishing Corporation, 2015)
      Attentional control is a key function of working memory that is hypothesized to play an important role in psychometric intelligence. To test the neuropsychological underpinnings of this hypothesis, we examined full-scale ...
    • Auditory Mismatch Negativity in Schizophrenia: Topographic Evaluation With a High-Density Recording Montage 

      Hirayasu, Yoshio; Potts, Geoffrey F.; O'Donnell, Brian F.; Kwon, Jun Soo; Arakaki, Hajime; Akdag, Sare J.; Levitt, James Jonathan; Shenton, Martha Elizabeth; McCarley, Robert William (American Psychiatric Publishing, 1998)
      Objective: The mismatch negativity, a negative component in the auditory event-related potential, is thought to index automatic processes involved in sensory or echoic memory. The authors’ goal in this study was to examine ...
    • A Cross-Sectional and Longitudinal Magnetic Resonance Imaging Study of Cingulate Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia and First-Episode Affective Psychosis 

      Koo, Min-Seong; Levitt, James Jonathan; Salisbury, Dean F.; Nakamura, Motoaki; Shenton, Martha Elizabeth; McCarley, Robert William (American Medical Association (AMA), 2008)
      Context: Previous magnetic resonance imaging (MRI) findings have demonstrated psychopathological symptom–related smaller gray matter volumes in various cingulate gyrus subregions in schizophrenia and bipolar disorder. ...
    • A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia 

      Levitt, James Jonathan; Kubicki, Marek R.; Nestor, Paul Gerard; Ersner-Hershfield, Hal; Westin, C-F; Alvarado, Jorge L.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal ...
    • DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 

      Kubicki, Marek R.; Park, H.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Mulkern, Robert Vincent; Maier, Stephan Ernst; Niznikiewicz, Margaret A.; Connor, E.E.; Levitt, James Jonathan; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ...
    • An elliptic PDE approach for shape characterization 

      Haidar, H.; Bouix, Sylvain; Levitt, James Jonathan; McCarley, Robert William; Shenton, Martha Elizabeth; Soul, Janet (IEEE, 2004)
      This paper presents a novel approach to analyze the shape of anatomical structures. Our methodology is rooted in classical physics and in particular Poisson's equation, a fundamental partial differential equation [1]. The ...
    • Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients 

      Kuroki, Noriomi; Kubicki, Marek R.; Nestor, Paul Gerard; Salisbury, Dean F.; Park, Hae-Jeong; Levitt, James Jonathan; Woolston, Sophie; Frumin, Melissa; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Maier, Stephan Ernst; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2006)
      Background: The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, ...
    • An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis 

      Wiegand, Laura C.; Warfield, Simon Keith; Levitt, James Jonathan; Hirayasu, Yoshio; Salisbury, Dean F.; Heckers, Stephan; Bouix, Sylvain; Schwartz, Daniel; Spencer, Magdalena; Dickey, Chandlee C.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2005)
      Objective: The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia. ...
    • MRI anatomy of schizophrenia 

      McCarley, Robert William; Wible, Cynthia Gayle; Frumin, Melissa; Hirayasu, Yoshio; Levitt, James Jonathan; Fischer, Iris A.; Shenton, Martha Elizabeth (Elsevier BV, 1999)
      Structural magnetic resonance imaging (MRI) data have provided much evidence in support of our current view that schizophrenia is a brain disorder with altered brain structure, and consequently involving more than a simple ...
    • MRI Study of Caudate Nucleus Volume and Its Cognitive Correlates in Neuroleptic-Naive Patients With Schizotypal Personality Disorder 

      Levitt, James Jonathan; McCarley, Robert William; Dickey, Chandlee C.; Voglmaier, Martina M.; Niznikiewicz, Margaret A.; Seidman, Larry Joel; Hirayasu, Yoshio; Ciszewski, Aleksandra A.; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2002)
      Objective: “Cognitive” circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of the core components of these circuits, such as in the caudate nucleus, may result in neurobehavioral ...
    • An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controls 

      Park, Hae-Jeong; Levitt, James Jonathan; Shenton, Martha Elizabeth; Salisbury, Dean F; Kubicki, Marek R.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (Elsevier BV, 2004)
      We created a spatial probability atlas of schizophrenia to provide information about the neuroanatomic variability of brain regions of patients with the disorder. Probability maps of 16 regions of interest (ROIs) were ...
    • Orbitofrontal volume deficit in schizophrenia and thought disorder 

      Nakamura, M.; Nestor, Paul Gerard; Levitt, James Jonathan; Cohen, Adam; Kawashima, T.; Shenton, Martha Elizabeth; McCarley, Robert William (Oxford University Press (OUP), 2008)
      Orbitofrontal Cortex (OFC) structural abnormality in schizophrenia has not been well characterized, probably due to marked anatomical variability and lack of consistent definitions. We previously reported OFC sulcogyral ...
    • Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study 

      Wible, Cynthia Gayle; Anderson, Jane; Shenton, Martha Elizabeth; Kricun, Ashley; Hirayasu, Yoshio; Tanaka, Shin; Levitt, James Jonathan; O, Brian F; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (Elsevier BV, 2001)
      The present study measured prefrontal cortical gray and white matter volume in chronic, male schizophrenic subjects who were characterized by a higher proportion of mixed or negative symptoms than previous patients that ...
    • Prefrontal cortical thickness in first-episode psychosis: a magnetic resonance imaging study 

      Wiegand, Laura C; Warfield, Simon Keith; Levitt, James Jonathan; Hirayasu, Yoshio; Salisbury, Dean F; Heckers, Stephan; Dickey, Chandlee C.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2004)
      Background: Findings from postmortem studies suggest reduced prefrontal cortical thickness in schizophrenia; however, cortical thickness in first-episode schizophrenia has not been evaluated using magnetic resonance imaging ...
    • Prefrontal Gray Matter Volume Reduction in First Episode Schizophrenia 

      Hirayasu, Y.; Tanaka, Shin; Shenton, Martha Elizabeth; Salisbury, Dean; DeSantis, Massimo A.; Levitt, James Jonathan; Wible, Cindy; Yurgelun-Todd, Deborah; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (Oxford University Press (OUP), 2001)
      Functional measures have consistently shown prefrontal abnormalities in schizophrenia. However, structural magnetic resonance imaging (MRI) findings of prefrontal volume reduction have been less consistent. In this study, ...
    • Quantitative Volumetric MRI Study of the Cerebellum and Vermis in Schizophrenia: Clinical and Cognitive Correlates 

      Levitt, James Jonathan; McCarley, Robert William; Nestor, Paul Gerard; Petrescu, Creola; Donnino, Robert; Hirayasu, Yoshio; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2016-09-14)
      Objective: Recent evidence suggests that the cerebellum may play a role in higher cognitive functions and, therefore, may play an important role in schizophrenia. Method: The authors used magnetic resonance imaging to ...
    • Reduced Left Angular Gyrus Volume in First-Episode Schizophrenia 

      Nierenberg, Jay; Salisbury, Dean F.; Levitt, James Jonathan; David, Elizabeth A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2005)
      Objective: Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in ...