Browsing by Author "Edge, Albert"

Now showing items 1-5 of 5

    • Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea 

      Geng, Ruishuang; Noda, Teppei; Mulvaney, Joanna F.; Lin, Vincent Y. W.; Edge, Albert S. B.; Dabdoub, Alain (Public Library of Science, 2016)
      Background: In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, ...

    • Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells 

      Li, Huawei; Liu, Hong; Corrales, C Eduardo; Risner, Jessica R; Forrester, Jeff; Holt, Jeffrey R; Heller, Stefan; Edge, Albert (BioMed Central, 2009)
      Background: Neural differentiation of embryonic stem (ES) cells is usually achieved by induction of ectoderm in embryoid bodies followed by the enrichment of neuronal progenitors using a variety of factors. Obtaining ...

    • Primary Culture and Plasmid Electroporation of the Murine Organ of Corti 

      Parker, Mark; Brugeaud, Aurore; Edge, Albert (Journal of Visualized Experiments, 2010)
      In all mammals, the sensory epithelium for audition is located along the spiraling organ of Corti that resides within the conch shaped cochlea of the inner ear (fig 1). Hair cells in the developing cochlea, which are the ...

    • Sox2 in the differentiation of cochlear progenitor cells 

      Kempfle, Judith S.; Turban, Jack L.; Edge, Albert S. B. (Nature Publishing Group, 2016)
      HMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, ...

    • Spiral Ganglion Stem Cells Can Be Propagated and Differentiated Into Neurons and Glia 

      Diensthuber, Marc; Zecha, Veronika; Wagenblast, Jens; Arnhold, Stefan; Edge, Albert S. B.; Stöver, Timo (Mary Ann Liebert, Inc., 2014)
      Abstract The spiral ganglion is an essential functional component of the peripheral auditory system. Most types of hearing loss are associated with spiral ganglion cell degeneration which is irreversible due to the inner ...