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    • Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence 

      Sedic, Maja; Skibinski, Adam; Brown, Nelson; Gallardo, Mercedes; Mulligan, Peter; Martinez, Paula; Keller, Patricia J.; Glover, Eugene; Richardson, Andrea L.; Cowan, Janet; Toland, Amanda E.; Ravichandran, Krithika; Riethman, Harold; Naber, Stephen P.; Näär, Anders M.; Blasco, Maria A.; Hinds, Philip W.; Kuperwasser, Charlotte (Nature Pub. Group, 2015)
      Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select ...