Browsing by Author "Wright, Robert"

Now showing items 1-20 of 38

    • Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. 

      Wright, Robert O.; Silverman, Edwin Kepner; Schwartz, Joel David; Tsaih, Shring-Wern; Senter, Jody; Sparrow, David; Weiss, Scott Tillman; Aro, Antonio; Hu, Howard (2004)
      Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...

    • Association between Prenatal Lead Exposure and Blood Pressure in Children 

      Zhang, Aimin; Hu, Howard; Sánchez, Brisa N.; Ettinger, Adrienne S; Park, Sung Kyun; Cantonwine, David; Schnaas, Lourdes; Wright, Robert O.; Lamadrid-Figueroa, Hector; Tellez-Rojo, Martha Maria (National Institute of Environmental Health Sciences, 2012)
      Background: Lead exposure in adults is associated with hypertension. Altered prenatal nutrition is associated with subsequent risks of adult hypertension, but little is known about whether prenatal exposure to toxicants, ...

    • Association Between the Plasma/Whole Blood Lead Ratio and History of Spontaneous Abortion: A Nested Cross-Sectional Study 

      Lamadrid-Figueroa, Héctor; Téllez-Rojo, Martha M; Hernández-Avila, Mauricio; Trejo-Valdivia, Belem; Solano-González, Maritsa; Mercado-Garcia, Adriana; Hu, Howard; Smith, Donald; Wright, Robert O. (BioMed Central, 2007)
      Background: Blood lead has been associated with an elevated risk of miscarriage. The plasmatic fraction of lead represents the toxicologically active fraction of lead. Women with a tendency to have a higher plasma/whole ...

    • Association of Cumulative Lead Exposure with Parkinson’s Disease 

      Weisskopf, Marc G.; Weuve, Jennifer Lynn; Nie, Huiling; Saint-Hilaire, Marie-Helene; Sudarsky, Lewis Richard; Simon, David K.; Hersh, Bonnie Patricia; Schwartz, Joel David; Wright, Robert O.; Hu, Howard (National Institute of Environmental Health Sciences, 2010)
      Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...

    • Association of Environmental Cadmium Exposure with Pediatric Dental Caries 

      Arora, Manish; Weuve, Jennifer Lynn; Schwartz, Joel David; Wright, Robert O. (National Institute of Environmental Health Sciences, 2008)
      Background: Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. Objectives: We aimed to examine the relationship between ...

    • Association of Environmental Cadmium Exposure with Periodontal Disease in U.S. Adults 

      Arora, Manish; Weuve, Jennifer Lynn; Schwartz, Joel David; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Periodontal disease is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Cadmium adversely affects bone remodeling, and it is ...

    • Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults 

      Ciesielski, Timothy; Bellinger, David C.; Schwartz, Joel David; Hauser, Russ B.; Wright, Robert O. (BioMed Central, 2013)
      Background: Low-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium ...

    • Associations of Early Childhood Manganese and Lead Coexposure with Neurodevelopment 

      Henn, Birgit Claus; Schnaas, Lourdes; Lamadrid-Figueroa, Héctor; Hernández-Avila, Mauricio; Hu, Howard; Téllez-Rojo, Martha María; Ettinger, Adrienne S; Schwartz, Joel David; Amarasiriwardena, Chitra J.; Bellinger, David C.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2011)
      Background: Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals. Objectives: We prospectively studied manganese–lead ...

    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...

    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...

    • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study 

      Mordukhovich, Irina; Wilker, Elissa Hope; Suh MacIntosh, Helen H.; Wright, Robert O.; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2009)
      Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...

    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...

    • Blood Lead Levels and Major Depressive Disorder, Panic Disorder, and Generalized Anxiety Disorder in US Young Adults 

      Bouchard, Maryse F.; Bellinger, David C; Weuve, Jennifer; Matthews-Bellinger, Julia; Gilman, Stephen Edward; Wright, Robert O.; Schwartz, Joel David; Weisskopf, Marc G. (American Medical Association (AMA), 2009)
      CONTEXT: Lead is a ubiquitous neurotoxicant, and adverse cognitive and behavioral effects are well-documented in children and occupationally exposed adults but not in adults with low environmental exposure. OBJECTIVE: To ...

    • Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children 

      Ciesielski, Timothy; Weuve, Jennifer Lynn; Bellinger, David C.; Schwartz, Joel David; Lanphear, Bruce; Wright, Robert O. (National Institute of Environmental Health Sciences, 2012)
      Background: Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes. Objective: Our aim was to evaluate associations between urinary cadmium concentration and reported ...

    • A Child with Chronic Manganese Exposure from Drinking Water 

      Woolf, Alan David; Wright, Robert O.; Amarasiriwardena, Chitra J.; Bellinger, David C. (U.S. Department of Health and Human Services & National Institute of Environmental Health Sciences, 2002)
      The patient's family bought a home in a suburb, but the proximity of the house to wetlands and its distance from the town water main prohibited connecting the house to town water. The family had a well drilled and they ...

    • Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. 

      Weisskopf, Marc G.; Hu, Howard; Mulkern, Robert Vincent; White, Roberta F; Aro, Antonio; Oliveira, Steven; Wright, Robert O. (2004)
      Seventy-one-year-old identical twin brothers with chronic lead poisoning were identified from an occupational medicine clinic roster. Both were retired painters, but one brother (J.G.) primarily removed paint and had a ...

    • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

      Perlstein, Todd Steven; Weuve, Jennifer Lynn; Schwartz, Joel David; Sparrow, David; Wright, Robert O.; Litonjua, Augusto Ampil; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...

    • HFE Gene Variants Modify the Association between Maternal Lead Burden and Infant Birthweight: A Prospective Birth Cohort Study in Mexico City, Mexico 

      Cantonwine, David; Hu, Howard; Téllez-Rojo, Martha Maria; Sánchez, Brisa N; Lamadrid-Figueroa, Héctor; Mercado-García, Adriana; Hernández-Avila, Mauricio; Ettinger, Adrienne S; Wright, Robert O. (BioMed Central, 2010)
      Background: Neonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which ...

    • HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the normative aging study 

      Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010)
      Background: Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...

    • Influence of Prenatal Lead Exposure on Genomic Methylation of Cord Blood DNA 

      Pilsner, J. Richard; Hu, Howard; Sánchez, Brisa N.; Cantonwine, David; Lazarus, Alicia; Lamadrid-Figueroa, Héctor; Mercado-García, Adriana; Téllez-Rojo, Martha Maria; Hernández-Avila, Mauricio; Ettinger, Adrienne S; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown. Epigenetic fetal ...