Browsing by Author "Lim, Sang Min"
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A Method for the Preparation of Differentiated \(trans\)-1,2-Diol Derivatives with Enantio- and Diastereocontrol
Lim, Sang Min; Hill, Nicholas; Myers, Andrew G. (American Chemical Society, 2009)We describe a synthetic sequence that allows for the preparation of optically active \(trans\)-1,2-diol monosilyl ether derivatives from ketones, providing a new means for retrosynthetic simplification of differentiated ... -
Unconventional Strategies to Target Challenging Enzymes Using Small-Molecule Covalent Inhibitors
Lim, Sang Min (2013-10-08)Unconventional strategies employing covalent small molecules were investigated to down-regulate signaling pathways mediated by enzymes that are challenging to target. First, Her3 was selectively degraded using covalent ...