Browsing by Author "Hemming, Matthew"

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Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

Elias, Joshua E.; Maas, Stefan; Gygi, Steven P.; Selkoe, Dennis J.; Hemming, Matthew Louis (Public Library of Science, 2009)

β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for ...
Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

Hemming, Matthew Louis; Elias, Joshua E; Gygi, Steven P.; Selkoe, Dennis J. (Public Library of Science, 2008)

The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins ...
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

Hemming, Matthew Louis; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole Stefan; Selkoe, Dennis J. (Public Library of Science, 2007)

Background: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is ...