Browsing by Author "Hemming, Matthew"
Now showing items 1-3 of 3
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Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Elias, Joshua E.; Maas, Stefan; Gygi, Steven P.; Selkoe, Dennis J.; Hemming, Matthew Louis (Public Library of Science, 2009)β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for ... -
Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
Hemming, Matthew Louis; Elias, Joshua E; Gygi, Steven P.; Selkoe, Dennis J. (Public Library of Science, 2008)The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins ... -
Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease
Hemming, Matthew Louis; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole Stefan; Selkoe, Dennis J. (Public Library of Science, 2007)Background: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is ...