Browsing by Author "Hemming, Matthew"

Now showing items 1-4 of 4

    • Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs 

      Flavahan, William A.; Drier, Yotam; Johnstone, Sarah E.; Hemming, Matthew; Tarjan, Daniel R.; Hegazi, Esmat; Shareef, Sarah; Javed, Nauman; Eschle, Benjamin K.; Gokhale, Prafulla C.; Hornick, Jason; Sicinska, Ewa; Demetri, George; Bernstein, Bradley (Springer Science and Business Media LLC, 2019-10-16)
      Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ...

    • Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics 

      Elias, Joshua E.; Maas, Stefan; Gygi, Steven P.; Selkoe, Dennis J.; Hemming, Matthew Louis (Public Library of Science, 2009)
      β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for ...

    • Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements 

      Hemming, Matthew Louis; Elias, Joshua E; Gygi, Steven P.; Selkoe, Dennis J. (Public Library of Science, 2008)
      The presenilin/γ-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins ...

    • Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease 

      Hemming, Matthew Louis; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole Stefan; Selkoe, Dennis J. (Public Library of Science, 2007)
      Background: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is ...