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    • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells 

      Niederreiter, Lukas; Fritz, Teresa M.J.; Adolph, Timon E.; Krismer, Anna-Maria; Offner, Felix A.; Tschurtschenthaler, Markus; Flak, Magdalena B.; Hosomi, Shuhei; Tomczak, Michal F.; Kaneider, Nicole C.; Sarcevic, Edina; Kempster, Sarah L.; Raine, Tim; Esser, Daniela; Rosenstiel, Philip; Kohno, Kenji; Iwawaki, Takao; Tilg, Herbert; Blumberg, Richard S.; Kaser, Arthur (The Rockefeller University Press, 2013)
      Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for ...
    • Paneth cells as a site of origin for intestinal inflammation 

      Adolph, Timon E.; Tomczak, Michal F.; Niederreiter, Lukas; Ko, Hyun-Jeong; Böck, Janne; Martinez-Naves, Eduardo; Glickman, Jonathan N.; Tschurtschenthaler, Markus; Hartwig, John; Hosomi, Shuhei; Flak, Magdalena B.; Cusick, Jennifer L.; Kohno, Kenji; Iwawaki, Takao; Billmann-Born, Susanne; Raine, Tim; Bharti, Richta; Lucius, Ralph; Kweon, Mi-Na; Marciniak, Stefan J.; Choi, Augustine; Hagen, Susan J.; Schreiber, Stefan; Rosenstiel, Philip; Kaser, Arthur; Blumberg, Richard S. (2013)
      Autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn’s disease (CD)1. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) ...