Now showing items 1-6 of 6

    • MAFG-Driven Astrocytes Promote CNS Inflammation 

      Wheeler, Michael; Clark, Iain; Tjon, Emily; Li, Zhaorong; Zandee, Stephanie E. J.; Couturier, Charles P.; Watson, Brianna; Scalisi, Giulia; Alkwai, Sarah; Rothhammer, Veit; Rotem, Assaf; Heyman, John; Thaploo, Shravan; Sanmarco, Liliana; Ragoussis, Jiannis; Weitz, David; Petrecca, Kevin; Moffitt, Jeffrey; Becher, Burkhard; Antel, Jack P.; Prat, Alexandre; Quintana, Francisco (Springer Science and Business Media LLC, 2020-02-12)
    • Molecular, Spatial, and Functional Single-Cell Profiling of the Hypothalamic Preoptic Region 

      Moffitt, Jeffrey; Bambah-Mukku, Dhananjay; Eichhorn, Stephen W.; Vaughn, Eric; Shekhar, Karthik; Perez, Julio D.; Rubinstein, Nimrod D.; Hao, Junjie; Regev, Aviv; Dulac, Catherine; Zhuang, Xiaowei (American Association for the Advancement of Science (AAAS), 2018-11-16)
      The hypothalamus controls essential social behaviors and homeostatic functions. However, the cellular architecture of hypothalamic nuclei, including the molecular identity, spatial organization, and function of distinct ...
    • Robust Circadian Oscillations in Growing Cyanobacteria Require Transcriptional Feedback 

      Teng, Shu-Wen; Mukherji, Shankar Shankar; Moffitt, Jeffrey R; de Buyl, Sophie; O'Shea, Erin K (American Association for the Advancement of Science, 2013)
      The remarkably stable circadian oscillations of single cyanobacteria enable a population of growing cells to maintain synchrony for weeks. The cyanobacterial pacemaker is a posttranslational regulation (PTR) circuit that ...
    • The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities 

      Moffitt, Jeffrey R; Lee, Jeffrey B.; Cluzel, Philippe (Royal Society of Chemistry (RSC), 2012)
      Optical microscopy of single bacteria growing on solid agarose support is a powerful method for studying the natural heterogeneity in growth and gene expression. While the material properties of agarose make it an excellent ...
    • Statistical Analysis of Molecular Signal Recording 

      Glaser, Joshua I.; Zamft, Bradley M.; Marblestone, Adam H.; Moffitt, Jeffrey R.; Tyo, Keith; Boyden, Edward S.; Church, George; Kording, Konrad P. (Public Library of Science, 2013)
      A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...
    • Super-resolution imaging reveals distinct chromatin folding for different epigenetic states 

      Boettiger, Alistair N.; Bintu, Bogdan; Moffitt, Jeffrey R.; Wang, Siyuan; Beliveau, Brian J.; Fudenberg, Geoffrey; Imakaev, Maxim; Mirny, Leonid A.; Wu, Chao-ting; Zhuang, Xiaowei (2015)
      Metazoan genomes are spatially organized at multiple scales, from packaging of DNA around individual nucleosomes to segregation of whole chromosomes into distinct territories1–5. At the intermediate scale of kilobases to ...