Browsing by Author "Vanderburg, Charles"

Now showing items 1-7 of 7

    • Assessment of Gene Order Computing Methods for Alzheimer's Disease 

      Hu, Benqiong; Jiang, Gang; Pang, Chaoyang; Wang, Shipeng; Liu, Qingzhong; Chen, Zhongxue; Vanderburg, Charles; Rogers, Jack; Deng, Youping; Huang, Xudong (Springer Science and Business Media LLC, 2013)
      Background Computational genomics of Alzheimer disease (AD), the most common form of senile dementia, is a nascent field in AD research. The field includes AD gene clustering by computing gene order which generates higher ...

    • Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients 

      Banigan, Meredith G.; Kao, Patricia F.; Kozubek, James A.; Winslow, Ashley R; Medina, Juan; Costa, Joan; Schmitt, Andrea; Schneider, Anja; Cabral, Howard; Cagsal-Getkin, Ozge; Vanderburg, Charles R.; Delalle, Ivana (Public Library of Science, 2013)
      Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell. We ...

    • Exosomal cell-to-cell transmission of alpha synuclein oligomers 

      Danzer, Karin M; Kranich, Lisa R; Ruf, Wolfgang P; Cagsal-Getkin, Ozge; Winslow, Ashley R; Zhu, Liya; Vanderburg, Charles R.; McLean, Pamela J (BioMed Central, 2012)
      Background: Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of sporadic and familial Parkinson’s disease (PD) as well as dementia with Lewy bodies, with recent evidence implicating oligomeric ...

    • Independent Component Analysis of Alzheimer's DNA Microarray Gene Expression Data 

      Kong, Wei; Mou, Xiaoyang; Liu, Qingzhong; Chen, Zhongxue; Vanderburg, Charles R.; Rogers, Jack Timothy; Huang, Xudong (BioMed Central, 2009)
      Background: Gene microarray technology is an effective tool to investigate the simultaneous activity of multiple cellular pathways from hundreds to thousands of genes. However, because data in the colossal amounts generated ...

    • Metal Exposure and Alzheimer’s Pathophysiology 

      Huang, Xudong; Rogers, Jack; Vanderburg, Charles; Lai, Barry; Dedeoglu, Alpasian (OMICS Publishing Group, 2014)

    • Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease 

      Kao, Patricia F.; Davis, David A.; Banigan, Meredith G.; Vanderburg, Charles R.; Seshadri, Sudha; Delalle, Ivana (Public Library of Science, 2010)
      During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites ...

    • A Special Local Clustering Algorithm for Identifying the Genes Associated With Alzheimer's Disease 

      Pang, Chao-Yang; Hu, Wei; Hu, Ben-Qiong; Shi, Ying; Vanderburg, Charles; Rogers, Jack; Huang, Xudong (Institute of Electrical and Electronics Engineers (IEEE), 2010-03)
      Clustering is the grouping of similar objects into a class. Local clustering feature refers to the phenomenon whereby one group of data is separated from another, and the data from these different groups are clustered ...