Browsing by Author "Schoen, Frederick"
Now showing items 1-6 of 6
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A Computational Model of Aging and Calcification in the Aortic Heart Valve
Weinberg, Eli J.; Schoen, Frederick Jack; Mofrad, Mohammad R. K. (Public Library of Science, 2009)The aortic heart valve undergoes geometric and mechanical changes over time. The cusps of a normal, healthy valve thicken and become less extensible over time. In the disease calcific aortic stenosis (CAS), calcified nodules ... -
Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges
Mendelson, Karen; Schoen, Frederick J. (Kluwer Academic Publishers-Plenum Publishers, 2006)Potential applications of tissue engineering in regenerative medicine range from structural tissues to organs with complex function. This review focuses on the engineering of heart valve tissue, a goal which involves a ... -
Hemodynamic Environments from Opposing Sides of Human Aortic Valve Leaflets Evoke Distinct Endothelial Phenotypes In Vitro
Weinberg, Eli J.; Mack, Peter J.; Schoen, Frederick Jack; García-Cardeña, Guillermo; Kaazempur Mofrad, Mohammad R. (Springer US, 2010)The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ... -
Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling
Ben‐Zvi, Danny; Savion, Naphtali; Kolodgie, Frank; Simon, Amos; Fisch, Sudeshna; Schäfer, Katrin; Bachner‐Hinenzon, Noa; Cao, Xin; Gertler, Arieh; Solomon, Gili; Kachel, Erez; Raanani, Ehud; Lavee, Jacob; Kotev Emeth, Shlomo; Virmani, Renu; Schoen, Frederick J.; Schneiderman, Jacob (John Wiley and Sons Inc., 2016)Background: Ascending thoracic aortic aneurysm (ATAA) is driven by angiotensin II (AngII) and contributes to the development of left ventricular (LV) remodeling through aortoventricular coupling. We previously showed that ... -
The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives†
Mathieu, Patrick; Bossé, Yohan; Huggins, Gordon S; Corte, Alessandro Della; Pibarot, Philippe; Michelena, Hector I.; Limongelli, Giuseppe; Boulanger, Marie‐Chloé; Evangelista, Arturo; Bédard, Elisabeth; Citro, Rodolfo; Body, Simon C; Nemer, Mona; Schoen, Frederick J (John Wiley and Sons Inc., 2015)Abstract Bicuspid aortic valve is the most prevalent cardiac valvular malformation. It is associated with a high rate of long‐term morbidity including development of calcific aortic valve disease, aortic regurgitation and ... -
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
Ducharme, Anique; Frantz, Stefan; Aikawa, Masanori; Rabkin, Elena; Lindsey, Merry; Rohde, Luis E.; Schoen, Frederick Jack; Kelly, Ralph A.; Werb, Zena; Libby, Peter; Lee, Richard Theodore (American Society for Clinical Investigation, 2000)Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental ...