Browsing by Author "Krainc, Dimitri"

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Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway

Jeong, Hyunkyung; Cohen, Dena E.; Cui, Libin; Supinski, Andrea; Savas, Jeffrey N.; Mazzulli, Joseph R; Yates, John R.; Bordone, Laura; Guarente, Leonard; Krainc, Dimitri (Nature Publishing Group, 2012)

Sirt1, an NAD-dependent protein deacetylase has emerged as important regulator of mammalian transcription in response to cellular metabolic status and stress. Here we demonstrate that Sirt1 plays a neuroprotective role in ...