Browsing by Author "Luo, Hongbo"
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Blockade of Glioma Proliferation through Allosteric Inhibition of JAK2
He, Kunyan; Qi, Qi; Chan, Chi-Bun; Xiao, Ge; Liu, Xia; Tucker-Burden, Carol; Wang, Liya; Mao, Hui; Lu, Xiang; McDonald, Frank E.; Luo, Hongbo; Fan, Qi-Wen; Weiss, William A.; Sun, Shi-Yong; Brat, Daniel J.; Ye, Keqiang (American Association for the Advancement of Science (AAAS), 2013)The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal ... -
Cancer Cell-Derived Clusterin Modulates the Phosphatidylinositol 3'-Kinase-Akt Pathway through Attenuation of Insulin-Like Growth Factor 1 during Serum Deprivation
Jo, Hakryul; Jia, Yonghui; Subramanian, Kulandayan K.; Hattori, Hidenori; Luo, Hongbo (American Society for Microbiology, 2008)Cancer cells in their respective microenvironments must endure various growth-constraining stresses. Under these conditions, the cancer cell-derived factors are thought to modulate the signaling pathways between cell growth ... -
Cigarette Smoke (CS) and Nicotine Delay Neutrophil Spontaneous Death via Suppressing Production of Diphosphoinositol Pentakisphosphate
Xu, Yuanfu; Li, Hongmei; Bajrami, Besnik; Kwak, Hyunjeong; Cao, Shannan; Liu, Peng; Zhou, Jiaxi; Zhou, Yuan; Zhu, Haiyan; Ye, Keqiang; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2013)Diphosphoinositol pentakisphosphate (InsP7), a higher inositol phosphate containing energetic pyrophosphate bonds, is beginning to emerge as a key cellular signaling molecule. However, the various physiological and ... -
Constitutive Neutrophil Apoptosis: Mechanisms and Regulation
Luo, Hongbo; Loison, Fabien (Wiley-Blackwell, 2008)Neutrophil constitutive death is a critical cellular process for modulating neutrophil number and function, and it plays an essential role in neutrophil homeostasis and the resolution of inflammation. Neutrophils die due ... -
Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
Jo, Hakryul; Lo, Pang-Kuo; Li, Yitang; Loison, Fabien; Green, Sarah; Wang, Jake; Silberstein, Leslie E.; Ye, Keqiang; Chen, Hexin; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
Deficiency of Lipid Phosphatase SHIP Enables Long-Term Reconstitution of Hematopoietic Inductive Bone Marrow Microenvironment
Liang, Olin Dehui; Lu, Jiayun; Nombela-Arrieta, César; Zhong, Jia; Zhao, Li; Pivarnik, Gregory; Mondal, Subhanjan; Chai, Li; Silberstein, Leslie E.; Luo, Hongbo (Elsevier BV, 2013)A dysfunctional bone marrow (BM) microenvironment is thought to contribute to the development of hematologic diseases. However, functional replacement of pathologic BM microenvironment through BM transplantation has not ... -
Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance
Chan, Chi Bun; Liu, Xia; Jung, Dae Young; Jun, John Y.; Luo, Hongbo; Kim, Jason K.; Ye, Keqiang (American Diabetes Association, 2010)OBJECTIVE: Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are ... -
A Dual Regulator of Neutrophil Recruitment
Luo, Hongbo (American Society of Hematology, 2014) -
E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice
Li, Zhenzhen; Ye, Zhou; Zhang, Xiaolong; Zhang, Qing; Fan, Dongmei; Zhang, Yanjun; Luo, Hongbo R.; Yuan, Xiangfei; Li, Zongfang; Xiong, Dongsheng (Impact Journals LLC, 2016)Gene therapy is an attractive approach for hepatocellular carcinoma (HCC) patients. Nevertheless, efficient transgene delivery remains a challenge. In this study, we explored a new targeted system based on human umbilical ... -
Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for Its Anti-Proliferative Activity
Oh, S.-M.; Liu, Z.; Okada, M.; Jang, S.-W.; Liu, X.; Chan, C.-B.; Luo, Hongbo; Ye, K. (Nature Publishing Group, 2010)Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation and acts as a putative tumor suppressor. Ebp1 translocates into the nucleus and functions as a transcription co-repressor for E2F-1. Here, we show that ... -
Exploiting Effectors of Rac GTPase
Jo, Hakryul; Luo, Hongbo (Elsevier BV, 2012) -
Fak Depletion in Both Hematopoietic and Nonhematopoietic Niche Cells Leads to Hematopoietic Stem Cell Expansion
Lu, Jiayun; Sun, Yan; Nombela-Arrieta, Cesar; Du, Karrie P.; Park, Shin-Young; Chai, Li; Walkley, Carl; Luo, Hongbo; Silberstein, Leslie E. (Elsevier BV, 2012)Hematopoietic stem cells (HSCs) reside in complex bone marrow microenvironments, where niche-induced signals regulate hematopoiesis. Focal adhesion kinase (Fak) is a nonreceptor protein tyrosine kinase that plays an essential ... -
Fas-Activated Serine/Threonine Phosphoprotein Promotes Immune-Mediated Pulmonary Inflammation
Simarro, Maria; Giannattasio, Giorgio; De la Fuente, Miguel A.; Benarafa, Charaf; Subramanian, Kulandayan K.; Ishizawar, Rumey Chang; Balestrieri, Barbara; Andersson, Emma M.; Luo, Hongbo; Orduna, Antonio; Boyce, Joshua A.; Anderson, Paul Joseph (The American Association of Immunologists, 2010)We generated Fas-activated serine threonine phosphoprotein (FAST)-deficient mice \((FAST^{−/−})\) to study the in vivo role of FAST in immune system function. In a model of house dust mite-induced allergic pulmonary ... -
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating both Adhesion-Dependent and -Independent Cellular Signals
Kasorn, Anongnard; Alcaide, Pilar; Jia, Yonghui; Subramanian, Kulandayan K.; Sarraj, Bara; Li, Yitang; Loison, Fabien; Hattori, Hidenori; Silberstein, Leslie E.; Luscinskas, William F.; Luo, Hongbo (American Association of Immunologists, 2009)Various neutrophil functions such as phagocytosis, superoxide production, and survival are regulated by integrin signaling. Despite the essential role of focal adhesion kinase (FAK) in mediating this signaling pathway, its ... -
Guanine Nucleotide Exchange Factor Vav1 Regulates Perivascular Homing and Bone Marrow Retention of Hematopoietic Stem and Progenitor Cells
Sanchez-Aguilera, Abel; Lee, Yun-Jung; Lo Celso, Cristina; Ferraro, Francesca; Brumme, Kristina; Mondal, Subhanjan; Kim, Chaekyun; Dorrance, Adrienne; Luo, Hongbo; Scadden, David Thomas; Williams, David Allan (Proceedings of the National Academy of Sciences, 2011)Engraftment and maintenance of hematopoietic stem and progenitor cells (HSPC) depend on their ability to respond to extracellular signals from the bone marrow microenvironment, but the critical intracellular pathways ... -
Identification of a Molecular Activator for Insulin Receptor with Potent Anti-Diabetic Effects
He, Kunyan; Chan, Chi-Bun; Liu, Xia; Jia, Yonghui; Luo, Hongbo; France, Stefan A.; Liu, Yang; Wilson, W. David; Ye, Keqiang (American Society for Biochemistry & Molecular Biology (ASBMB), 2011)Insulin exerts its actions through the insulin receptor (IR) and plays an essential role in diabetes. The inconvenient daily injection and undesirable side-effects associated with insulin injection demand novel drugs for ... -
Inhibitors of Neutrophil Recruitment Identified Using Transgenic Zebrafish to Screen a Natural Product Library
Wang, Xingang; Robertson, Anne L.; Li, Jingyu; Chai, Ruth Jinfen; Haishan, Wang; Sadiku, Pranvera; Ogryzko, Nikolay V.; Everett, Martin; Yoganathan, Kanagasundaram; Luo, Hongbo; Renshaw, Stephen A.; Ingham, Philip W. (The Company of Biologists, 2013)Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo ... -
Inositol Hexakisphosphate Kinase 1 Regulates Neutrophil Function in Innate Immunity by Inhibiting Phosphatidylinositol-(3,4,5)-Trisphosphate Signaling
Prasad, Amit; Jia, Yonghui; Chakraborty, Anutosh; Li, Yitang; Jain, Supriya K.; Zhong, Jia; Roy, Saurabh Ghosh; Loison, Fabien; Mondal, Subhanjan; Sakai, Jiro; Blanchard, Catlyn; Snyder, Solomon H.; Luo, Hongbo (Nature Publishing Group, 2011)Inositol phosphates are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here we demonstrate that disruption of inositol hexakisphosphate ... -
Inositol Trisphosphate 3-Kinase B (InsP3KB) as a Physiological Modulator of Myelopoiesis
Jia, Yonghui; Loison, Fabien; Hattori, Hidenori; Li, Yitang; Erneux, Christophe; Park, Shin-Young; Gao, Chong; Chai, Li; Silberstein, Leslie E.; Schurmans, Stephane; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2008)Inositol trisphosphate 3-kinase B (InsP3KB) belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Previous studies have shown ... -
Inositol Trisphosphate 3-Kinase B Is Increased in Human Alzheimer Brain and Exacerbates Mouse Alzheimer Pathology
Stygelbout, Virginie; Leroy, Karelle; Pouillon, Valerie; Ando, Kunie; D’Amico, Eva; Jia, Yonghui; Luo, Hongbo; Duyckaerts, Charles; Erneux, Christophe; Schurmans, Stephane; Brion, Jean-Pierre (Oxford University Press (OUP), 2014)ITPKB phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate and controls signal transduction in various hematopoietic cells. Surprisingly, it has been reported that the ITPKB messenger RNA ...