Browsing by Author "Wong, Eric"
Now showing items 1-13 of 13
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Clinical benefit in recurrent glioblastoma from adjuvant NovoTTF-100A and TCCC after temozolomide and bevacizumab failure: a preliminary observation
Wong, Eric T; Lok, Edwin; Swanson, Kenneth D (BlackWell Publishing Ltd, 2015)The NovoTTF-100A is a device that emits alternating electric fields and it is approved for the treatment of recurrent glioblastoma. It works by perturbing tumor cells during mitosis as they enter anaphase leading to ... -
Computed modeling of alternating electric fields therapy for recurrent glioblastoma
Lok, Edwin; Hua, Van; Wong, Eric T (John Wiley & Sons, Ltd, 2015)Tumor treating fields (TTFields) are alternating electric fields frequency tuned to 200 kHz for the treatment of recurrent glioblastoma. We report a patient treated with TTFields and determined the distribution of TTFields ... -
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy
Mahadevan, Anand; Sampson, Carrie; LaRosa, Salvatore; Floyd, Scott R.; Wong, Eric T.; Uhlmann, Erik J.; Sengupta, Soma; Kasper, Ekkehard M. (BioMed Central, 2015)Background: Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation ... -
An Evidence-Based Review of Alternating Electric Fields Therapy for Malignant Gliomas
Wong, Eric T; Lok, Edwin; Swanson, Kenneth D. (Springer US, 2015)Opinion statement Glioblastoma is a deadly disease and even aggressive neurosurgical resection followed by radiation and chemotherapy only extends patient survival to a median of 1.5 years. The challenge in treating this ... -
Gefitinib and High-Dose Fractionated Radiotherapy for Carcinomatous Encephalitis from Non-Small Cell Lung Carcinoma
Wong, Eric T.; Wu, Julian K.; Mahadevan, Anand (Dove Medical Press, 2007)Carcinomatous encephalitis is a rapidly fatal form of metastasis caused by miliary spread of systemic cancer into the brain parenchyma. The diagnostic criteria and optimal treatment for this disease are not well defined. ... -
Hypofractionated Radiotherapy and Stereotactic Boost with Concurrent and Adjuvant Temozolamide for Glioblastoma in Good Performance Status Elderly Patients – Early Results of a Phase II Trial
Floyd, Scott Richard; Kasper, Ekkehard Matthias; Uhlmann, Erik J; Fonkem, Ekokobe; Wong, Eric T.; Mahadevan, Anand (Frontiers Media S.A., 2012)Glioblastoma Multiforme (GBM) is an aggressive primary brain neoplasm with dismal prognosis. Based on successful phase III trials, 60 Gy involved-field radiotherapy in 30 fractions over 6 weeks [Standard radiation therapy ... -
Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
Timmons, Joshua J.; Cohessy, Sean; Wong, Eric T. (MyJove Corporation, 2016)Approximately 90% of human cancer deaths are linked to metastasis. Despite the prevalence and relative harm of metastasis, therapeutics for treatment or prevention are lacking. We report a method for the establishment of ... -
A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma
Wang, Fengfei; Remke, Marc; Bhat, Kruttika; Wong, Eric T.; Zhou, Shuang; Ramaswamy, Vijay; Dubuc, Adrian; Fonkem, Ekokobe; Salem, Saeed; Zhang, Hongbing; Hsieh, Tze-chen; O'Rourke, Stephen T.; Wu, Lizi; Li, David W.; Hawkins, Cynthia; Kohane, Isaac S.; Wu, Joseph M.; Wu, Min; Taylor, Michael D.; Wu, Erxi (Impact Journals LLC, 2015)Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly ... -
An Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant Glioma
Swanson, Kenneth D.; Lok, Edwin; Wong, Eric T. (Springer US, 2016)As with many cancer treatments, tumor treating fields (TTFields) target rapidly dividing tumor cells. During mitosis, TTFields-exposed cells exhibit uncontrolled membrane blebbing at the onset of anaphase, resulting in ... -
Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas
Wong, Eric T.; Timmons, Joshua; Callahan, Amy; O’Loughlin, Lauren; Giarusso, Bridget; Alsop, David C. (BioMed Central, 2016)Background: The treatment goal for recurrent malignant gliomas centers on disease stabilization while minimizing therapy-related side effects. Metronomic dosing of cytotoxic chemotherapy has emerged as a promising option ... -
The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo
Lu, Renquan; Wu, Chengsheng; Guo, Lin; Liu, Yingchao; Mo, Wei; Wang, Huijie; Ding, Jianbo; Wong, Eric T.; Yu, Min (BioMed Central, 2012)Background: Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms ... -
Stereotactic Radiosurgery for Renal Cancer Brain Metastasis: Prognostic Factors and the Role of Whole-Brain Radiation and Surgical Resection
Ippen, Franziska M.; Mahadevan, Anand; Wong, Eric T.; Uhlmann, Erik J.; Sengupta, Soma; Kasper, Ekkehard M. (Hindawi Publishing Corporation, 2015)Background:. Renal cell carcinoma is a frequent source of brain metastasis. We present our consecutive series of patients treated with Stereotactic Radiosurgery (SRS) and analyse prognostic factors and the interplay of ... -
Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit
Gera, Nidhi; Yang, Aaron; Holtzman, Talia S.; Lee, Sze Xian; Wong, Eric T.; Swanson, Kenneth D. (Public Library of Science, 2015)The anti-tumor effects of chemotherapy and radiation are thought to be mediated by triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel, block metaphase exit by initiating the spindle ...