Now showing items 1-20 of 23

    • Allergic Lung Inflammation Aggravates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Wemmelund, Holger; Ren, Jingyuan; Fernandes, Cleverson; Zhou, Yi; Sukhova, Galina K.; Lindholt, Jes S.; Johnsen, Søren P.; Zhang, Jin-Ying; Cheng, Xiang; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2015)
    • Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice 

      Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Santos, Marcela Malheiro; Fernandes, Cleverson; Sukhova, Galina K.; Zhang, Jin-Ying; Cheng, Xiang; Yang, Chongzhe; Huang, Xiaozhu; Levy, Bruce David; Libby, Peter; Wu, Gongxiong; Shi, Guo-Ping (Elsevier BV, 2016)
      Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas ...
    • Asthma Associates With Human Abdominal Aortic Aneurysm and RuptureSignificance 

      Liu, Cong-Lin; Wemmelund, Holger; Wang, Yi; Liao, Mengyang; Lindholt, Jes S.; Johnsen, Søren P.; Vestergaard, Henrik; Fernandes, Cleverson; Sukhova, Galina K.; Cheng, Xiang; Zhang, Jin-Ying; Yang, Chongzhe; Huang, Xiaozhu; Daugherty, Alan; Levy, Bruce David; Libby, Peter; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2016)
      Objective—Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results—Databases analyzed included Danish National Registry of Patients, ...
    • Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
    • Cathepsin K knockout alleviates aging-induced cardiac dysfunction 

      Hua, Yinan; Robinson, Timothy J; Cao, Yongtao; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (BlackWell Publishing Ltd, 2014)
      Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin ...
    • Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction 

      Hua, Yinan; Zhang, Yingmei; Dolence, Julia; Shi, Guo-Ping; Ren, Jun; Nair, Sreejayan (American Diabetes Association, 2013)
      The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction. Wild-type mice fed a ...
    • Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, S.; Libby, Peter; Xiang, M.; Wang, J.; Peters, C.; Reinheckel, T.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ...
    • Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells 

      Liu, Jian; Sukhova, Galina K.; Yang, Jin-Tian; Sun, Jiusong; Ma, Likun; Ren, An; Xu, Wei-Hua; Fu, Huanxiang; Dolganov, Gregory M.; Hu, Chengcheng; Libby, Peter; Shi, Guo-Ping (Elsevier BV, 2006)
      The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The ...
    • Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K−Akt/p-HDAC6 Signaling Pathway 

      Wu, Hongxian; Cheng, Xian Wu; Hu, Lina; Takeshita, Kyosuke; Hu, Chen; Du, Qiuna; Li, Xiang; Zhu, Enbo; Huang, Zhe; Yisireyili, Maimaiti; Zhao, Guangxian; Piao, Limei; Inoue, Aiko; Jiang, Haiying; Lei, Yanna; Zhang, Xiaohong; Liu, Shaowen; Dai, Qiuyan; Kuzuya, Masafumi; Shi, Guo-Ping; Murohara, Toyoaki (Lippincott Williams & Wilkins, 2016)
      Objective— Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell development. Histone deacetylase 6 ...
    • Cystatin C deficiency in human atherosclerosis and aortic aneurysms 

      Shi, Guo-Ping; Sukhova, Galina K.; Grubb, Anders; Ducharme, Anique; Rhode, Luis H.; Lee, Richard Theodore; Ridker, Paul M.; Libby, Peter; Chapman, Harold A. (American Society for Clinical Investigation, 1999)
      The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin ...
    • Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice 

      Sukhova, Galina K.; Zhang, Yaou; Pan, Jie-Hong; Wada, Youichiro; Yamamoto, Takashi; Naito, Makoto; Kodama, Tatsuhiko; Tsimikas, Sotirios; Witztum, Joseph L.; Lu, Michael L.; Sakara, Yasuhiko; Chin, Michael T.; Libby, Peter; Shi, Guo-Ping (American Society for Clinical Investigation, 2003)
      Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor ...
    • Deletion of EP4 on Bone Marrow-Derived Cells Enhances Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation 

      Tang, E. H. C.; Shvartz, E.; Shimizu, K.; Rocha, V. Z.; Zheng, Chunyu; Fukuda, D.; Shi, Guo-Ping; Sukhova, Galina K.; Libby, Peter (Ovid Technologies (Wolters Kluwer Health), 2010)
      Objective—To examine whether a lack of prostaglandin E receptor 4 (EP4) on bone marrow–derived cells would increase local inflammation and enhance the formation of abdominal aortic aneurysm (AAA) in vivo. Methods and ...
    • Different Roles of Mast Cells in Obesity and Diabetes: Lessons from Experimental Animals and Humans 

      Shi, Michael A.; Shi, Guo-Ping (Frontiers Research Foundation, 2012)
      Mast cells (MCs) play an important role in allergic hyperresponsiveness and in defending microorganism infections. Recent studies of experimental animals and humans have suggested that MCs participate in obesity and diabetes. ...
    • Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells 

      Sukhova, Galina K.; Shi, Guo-Ping; Simon, D I; Chapman, H A; Libby, Peter (American Society for Clinical Investigation, 1998)
      Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear. This study examined the expression ...
    • A Guanidine-rich Regulatory Oligodeoxynucleotide Improves Type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation 

      Cheng, Xiang; Wang, Jing; Xia, Ni; Yan, Xin-Xin; Tang, Ting-Ting; Chen, Han; Zhang, Hong-Jian; Liu, Juan; Kong, Wen; Sjöberg, Sara; Folco, Eduardo; Libby, Peter; Liao, Yu-Hua; Shi, Guo-Ping (WILEY-VCH Verlag, 2012)
      T lymphocytes exhibit pro-inflammatory or anti-inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine-rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2-cell ...
    • IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms 

      Wang, Jing; Lindholt, Jes S; Sukhova, Galina K; Shi, Michael A; Xia, Mingcan; Chen, Han; Xiang, Meixiang; He, Aina; Wang, Yi; Xiong, Na; Libby, Peter; Wang, Jian-An; Shi, Guo-Ping (BlackWell Publishing Ltd, 2014)
      Immunoglobulin E (IgE) activates mast cells (MCs). It remains unknown whether IgE also activates other inflammatory cells, and contributes to the pathogenesis of abdominal aortic aneurysms (AAAs). This study demonstrates ...
    • Image-guided percutaneous renal cryoablation for stage 1 renal cell carcinoma with high surgical risk 

      Yan, Xiang; Zhang, Mingxin; Chen, Xiaoxiang; Wei, Wang; Yang, Rong; Yang, Yang; Gan, Weidong; Guo, Hongqian; Wang, Yang; Shi, Guo-Ping (BioMed Central, 2015)
      Background: This study was undertaken to evaluate the feasibility, safety, and therapeutic effects of percutaneous renal cryoablation under local anesthesia with conscious sedation for patients who have unresectable stage ...
    • Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter 

      Wang, Jing; Sun, Chongxiu; Gerdes, Norbert; Liu, Conglin; Liao, Mengyang; Liu, Jianping; Shi, Michael A; He, Aina; Zhou, Yi; Sukhova, Galina K.; Chen, Huimei; Cheng, Xian; Kuzuya, Masafumi; Murohara, Toyoaki; Zhang, Jie; Cheng, Xiang; Jiang, Mengmeng; Shull, Gary E; Rogers, Shaunessy; Yang, Chao-Ling; Ke, Qiang; Jelen, Sabina; Bindels, René; Ellison, David H; Jarolim, Petr; Libby, Peter; Shi, Guo-Ping (Nature Publishing Group, 2015)
      Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms1, 2. Interruption of IL18 action reduces atherosclerosis in mice3, 4. Here, we show that absence of the IL18 receptor (IL18r) does not ...
    • Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions 

      Tang, E. H. C.; Shimizu, K.; Christen, T.; Rocha, V. Z.; Shvartz, E.; Tesmenitsky, Y.; Sukhova, Galina K.; Shi, Guo-Ping; Libby, Peter (Oxford University Press (OUP), 2010)
      Aim: Prostaglandin E2, by ligation of its receptor EP4, suppresses the production of inflammatory cytokines and chemokines in macrophages in vitro. Thus, activation of EP4 may constitute an endogenous anti-inflammatory ...
    • Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice 

      Sun, Jiusong; Sukhova, Galina K.; Yang, Min; Wolters, Paul J.; MacFarlane, Lindsey Adair; Libby, Peter; Sun, Chongxiu; Zhang, Yadong; Liu, Jianming; Ennis, Terri L.; Knispel, Rebecca; Xiong, Wanfen; Thompson, Robert W.; Baxter, B. Timothy; Shi, Guo-Ping (American Society for Clinical Investigation, 2007)
      Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of ...